| Incyte Corporation | 30.8M | US$3.49B | 17.5% |
| Beone Medicines Ltd. Class A | 8.8M | US$2.51B | 12.6% |
| Revolution Medicines, Inc. | 11.4M | US$2.14B | 10.7% |
| Madrigal Pharmaceuticals, Inc. | 2.14M | US$1.15B | 5.8% |
| Acadia Pharmaceuticals Inc. | 42.9M | US$1.09B | 5.4% |
| Kymera Therapeutics, Inc. | 8.66M | US$993M | 5.0% |
| Insmed Incorporated | 8.8M | US$938M | 4.7% |
| Celcuity Inc. | 7.92M | US$828M | 4.2% |
| Kodiak Sciences Inc | 19.9M | US$776M | 3.9% |
| Rhythm Pharmaceuticals, Inc. | 5.6M | US$622M | 3.1% |
| Praxis Precision Medicines, Inc. | 1.75M | US$587M | 2.9% |
| Summit Therapeutics Inc. | 32.8M | US$478M | 2.4% |
| Grail, Inc. | 4.03M | US$275M | 1.4% |
| Abcellera Biologics Inc. | 33M | US$259M | 1.3% |
| Immunovant, Inc. | 5.44M | US$209M | 1.0% |
| Ideaya Biosciences, Inc. | 5.01M | US$187M | 0.94% |
| Roivant Sciences Ltd. | 4.72M | US$167M | 0.84% |
| Arrowhead Pharmaceuticals, Inc. | 1.99M | US$162M | 0.81% |
| Ionis Pharmaceuticals, Inc. | 2.05M | US$162M | 0.81% |
| Edgewise Therapeutics, Inc. | 3.7M | US$150M | 0.75% |
| Replimune Group, Inc. | 11M | US$122M | 0.61% |
| Nurix Therapeutics, Inc. | 4.66M | US$113M | 0.57% |
| Stoke Therapeutics, Inc. | 3.34M | US$109M | 0.55% |
| Monte Rosa Therapeutics, Inc. | 4.35M | US$105M | 0.53% |
| Denali Therapeutics Inc. | 3.73M | US$96M | 0.48% |
| Crinetics Pharmaceuticals, Inc. | 2.35M | US$88M | 0.44% |
| Dianthus Therapeutics, Inc. | 852K | US$83.1M | 0.42% |
| Rapport Therapeutics, Inc. | 1.55M | US$64.5M | 0.32% |
| Alumis Inc. | 2.01M | US$56.6M | 0.28% |
| Prelude Therapeutics Incorporated | 10.1M | US$54M | 0.27% |
| Relay Therapeutics, Inc. | 2.83M | US$52.9M | 0.27% |
| Mirum Pharmaceuticals, Inc. | 446K | US$52.2M | 0.26% |
| Enliven Therapeutics, Inc. | 905K | US$45.9M | 0.23% |
| Celldex Therapeutics, Inc. | 1.18M | US$44M | 0.22% |
| Viridian Therapeutics, Inc. | 2.38M | US$43.8M | 0.22% |
| Design Therapeutics, Inc. | 2.68M | US$38.8M | 0.19% |
| Entrada Therapeutics, Inc. | 5.07M | US$37.3M | 0.19% |
| Sensei Biotherapeutics, Inc. | 1.29M | US$32.2M | 0.16% |
| Aktis Oncology, Inc. | 996K | US$32.1M | 0.16% |
| Neurogene Inc. | 992K | US$31.2M | 0.16% |
| Jade Biosciences, Inc. | 1.23M | US$27.3M | 0.14% |
| Taysha Gene Therapies, Inc. | 4M | US$27.3M | 0.14% |
| Arcus Biosciences, Inc. | 845K | US$26M | 0.13% |
| Disc Medicine, Inc. | 350K | US$25.6M | 0.13% |
| Absci Corporation | 2.13M | US$24.7M | 0.12% |
| Generate Biomedicines, Inc. | 1.42M | US$24M | 0.12% |
| Dbv Technologies Sa | 1.46M | US$24M | 0.12% |
| Xenon Pharmaceuticals Inc. | 370K | US$22.3M | 0.11% |
| Tectonic Therapeutic, Inc. | 608K | US$20.9M | 0.10% |
| Cerus Corporation | 6.4M | US$18.7M | 0.09% |
| Cytomx Therapeutics, Inc. | 4.98M | US$18.7M | 0.09% |
| Dyne Therapeutics, Inc. | 813K | US$18.1M | 0.09% |
| Cytokinetics, Incorporated | 211K | US$18M | 0.09% |
| Xencor, Inc. | 1.1M | US$17.7M | 0.09% |
| Sionna Therapeutics, Inc. | 400K | US$17.6M | 0.09% |
| Intellia Therapeutics, Inc. | 930K | US$15.7M | 0.08% |
| Parabilis Medicines, Inc. | 500K | US$13.7M | 0.07% |
| Maplight Therapeutics, Inc. | 365K | US$13.1M | 0.07% |
| Avalyn Pharma Inc. | 350K | US$11.5M | 0.06% |
| Evommune, Inc. | 847K | US$11.3M | 0.06% |
| Tango Therapeutics, Inc. | 333K | US$10.4M | 0.05% |
| Avalo Therapeutics, Inc. | 550K | US$10.2M | 0.05% |
| Sera Prognostics, Inc. | 5.5M | US$10M | 0.05% |
| Verastem, Inc. | 2.5M | US$9.55M | 0.05% |
| Sagimet Biosciences Inc. - Series A | 953K | US$7.37M | 0.04% |
| Eikon Therapeutics, Inc. | 556K | US$7.25M | 0.04% |
| Lb Pharmaceuticals Inc | 200K | US$6.49M | 0.03% |
| Vtv Therapeutics Inc. | 148K | US$5.58M | 0.03% |
| Protara Therapeutics, Inc. | 972K | US$3.71M | 0.02% |
| Tscan Therapeutics, Inc. | 2.78M | US$2.73M | 0.01% |
| Immunome, Inc. | 55,306 | US$1.17M | <0.01% |
| Skye Bioscience, Inc. | 1.58M | US$1.09M | <0.01% |
| Sana Biotechnology, Inc. | 310K | US$1.08M | <0.01% |
| Aligos Therapeutics, Inc. | 83,055 | US$479K | <0.01% |
| Tyra Biosciences, Inc. | 10,607 | US$339K | <0.01% |
| Spyre Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Abivax Sa | 0 | US$0 | 0.00% |
| Argenx Se | 0 | US$0 | 0.00% |
| Contineum Therapeutics, Inc. | 0 | US$0 | 0.00% |