| Jazz Pharmaceuticals Plc | 258K | US$65.3M | 5.7% |
| Amgen Inc. | 132K | US$50.7M | 4.4% |
| Gilead Sciences, Inc. | 342K | US$44.5M | 3.9% |
| Regeneron Pharmaceuticals, Inc. | 57,013 | US$43.5M | 3.8% |
| Argenx Se | 48,962 | US$41.8M | 3.6% |
| Vertex Pharmaceuticals Incorporated | 85,620 | US$40.8M | 3.5% |
| Revolution Medicines, Inc. | 185K | US$34.8M | 3.0% |
| Guardant Health, Inc. | 197K | US$31.8M | 2.8% |
| Ascendis Pharma A/s | 121K | US$29.6M | 2.6% |
| Oruka Therapeutics, Inc. | 296K | US$28.6M | 2.5% |
| Dianthus Therapeutics, Inc. | 250K | US$26.8M | 2.3% |
| Spyre Therapeutics, Inc. | 245K | US$24.1M | 2.1% |
| Insmed Incorporated | 233K | US$23M | 2.0% |
| Mirum Pharmaceuticals, Inc. | 215K | US$22.8M | 2.0% |
| Praxis Precision Medicines, Inc. | 71,799 | US$22.1M | 1.9% |
| Neurocrine Biosciences, Inc. | 126K | US$21M | 1.8% |
| Bridgebio Pharma, Inc. | 241K | US$19.3M | 1.7% |
| Ptc Therapeutics, Inc. | 280K | US$19M | 1.6% |
| Astrazeneca Plc | 103K | US$17.4M | 1.5% |
| Amylyx Pharmaceuticals, Inc. | 753K | US$15.3M | 1.3% |
| Eli Lilly And Company | 13,131 | US$15.1M | 1.3% |
| Cytokinetics, Incorporated | 186K | US$14.3M | 1.2% |
| Tango Therapeutics, Inc. | 522K | US$14.2M | 1.2% |
| Eyepoint, Inc. | 1.12M | US$13.8M | 1.2% |
| Abivax Sa | 109K | US$13.6M | 1.2% |
| Mineralys Therapeutics, Inc. | 534K | US$13.6M | 1.2% |
| Arcutis Biotherapeutics, Inc. | 506K | US$13.6M | 1.2% |
| Indivior Pharmaceuticals, Inc. | 332K | US$13.3M | 1.2% |
| Thermo Fisher Scientific Inc | 22,999 | US$13.2M | 1.1% |
| Dyne Therapeutics, Inc. | 519K | US$13.1M | 1.1% |
| Bicara Therapeutics Inc. | 475K | US$12.9M | 1.1% |
| Cg Oncology, Inc. | 175K | US$12.4M | 1.1% |
| Benitec Biopharma Inc. | 995K | US$11.7M | 1.0% |
| Alkermes Plc | 233K | US$11.4M | 0.99% |
| Solid Biosciences Inc. | 1.41M | US$11.4M | 0.98% |
| Syndax Pharmaceuticals, Inc. | 583K | US$11.1M | 0.96% |
| Ionis Pharmaceuticals, Inc. | 209K | US$10.8M | 0.94% |
| Beone Medicines Ltd. Class A | 33,421 | US$10.6M | 0.92% |
| Alnylam Pharmaceuticals, Inc. | 51,286 | US$10.5M | 0.91% |
| Contineum Therapeutics, Inc. | 625K | US$9.68M | 0.84% |
| Jade Biosciences, Inc. | 480K | US$9.48M | 0.82% |
| Alto Neuroscience, Inc. | 348K | US$9.42M | 0.82% |
| Vaxcyte, Inc. | 146K | US$7.88M | 0.68% |
| Xenon Pharmaceuticals Inc. | 124K | US$7.76M | 0.67% |
| Relay Therapeutics, Inc. | 405K | US$7.63M | 0.66% |
| Oric Pharmaceuticals, Inc. | 659K | US$7.3M | 0.63% |
| Neurogene Inc. | 219K | US$7.2M | 0.62% |
| Achieve Life Sciences, Inc. | 1.1M | US$7.03M | 0.61% |
| Olema Pharmaceuticals, Inc. | 569K | US$6.51M | 0.56% |
| Mbx Biosciences, Inc. | 85,528 | US$5.64M | 0.49% |
| Artiva Biotherapeutics, Inc. | 542K | US$5.48M | 0.47% |
| Aura Biosciences, Inc. | 766K | US$5.37M | 0.46% |
| Newamsterdam Pharma Company N.v. | 188K | US$5.22M | 0.45% |
| Sionna Therapeutics, Inc. | 108K | US$5.09M | 0.44% |
| Krystal Biotech, Inc. | 14,607 | US$4.98M | 0.43% |
| Sensei Biotherapeutics, Inc. | 181K | US$4.92M | 0.43% |
| Inventiva Sa | 1.01M | US$4.55M | 0.39% |
| Phathom Pharmaceuticals, Inc. | 507K | US$4.44M | 0.38% |
| Relmada Therapeutics, Inc. | 789K | US$4.19M | 0.36% |
| Palisade Bio, Inc. | 2.12M | US$4.02M | 0.35% |
| Celcuity Inc. | 46,107 | US$3.98M | 0.35% |
| Uniqure N.v. | 88,716 | US$3.87M | 0.34% |
| Definium Therapeutics, Inc. | 86,980 | US$3.79M | 0.33% |
| Oculis Holding Ag | 315K | US$3.56M | 0.31% |
| Avalyn Pharma Inc. | 120K | US$3.47M | 0.30% |
| Satellos Bioscience Inc | 343K | US$3.43M | 0.30% |
| Veradermics, Incorporated | 31,081 | US$3.26M | 0.28% |
| Grail, Inc. | 46,433 | US$3.18M | 0.28% |
| Parabilis Medicines, Inc. | 93,010 | US$3.16M | 0.27% |
| Vor Biopharma Inc. | 149K | US$3.15M | 0.27% |
| Kardigan, Inc. | 145K | US$3.02M | 0.26% |
| Immix Biopharma, Inc. | 357K | US$2.97M | 0.26% |
| Cogent Biosciences, Inc. | 75,829 | US$2.95M | 0.26% |
| Ideaya Biosciences, Inc. | 81,852 | US$2.91M | 0.25% |
| Avalo Therapeutics, Inc. | 148K | US$2.7M | 0.23% |
| Ultragenyx Pharmaceutical Inc. | 108K | US$2.69M | 0.23% |
| Kailera Therapeutics, Inc. | 146K | US$2.48M | 0.21% |
| Cabaletta Bio, Inc. | 877K | US$2.35M | 0.20% |
| Verastem, Inc. | 402K | US$2.33M | 0.20% |
| Adicet Bio, Inc. | 225K | US$2.05M | 0.18% |
| Tyra Biosciences, Inc. | 62,752 | US$2M | 0.17% |
| Sartorius Stedim Biotech Sa | 10,100 | US$1.95M | 0.17% |
| Spyglass Pharma, Inc. | 84,708 | US$1.91M | 0.17% |
| Odyssey Therapeutics, Inc. | 99,826 | US$1.89M | 0.16% |
| Acumen Pharmaceuticals, Inc. | 826K | US$1.78M | 0.15% |
| Jatt Ii Acquisition Corp | 147K | US$1.78M | 0.15% |
| Bioage Labs, Inc. | 135K | US$1.22M | 0.11% |
| Eikon Therapeutics, Inc. | 127K | US$1.17M | 0.10% |
| Assembly Biosciences, Inc. | 40,982 | US$1.03M | 0.09% |
| Context Therapeutics Inc. | 1.4M | US$838K | 0.07% |
| Inflarx N.v. | 376K | US$639K | 0.06% |
| Cardiff Oncology, Inc. | 439K | US$375K | 0.03% |
| In8bio, Inc. | 332K | US$345K | 0.03% |
| Vicore Pharma Holding Ab | 8 | US$9 | <0.01% |
| Ars Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Zentalis Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Nuvalent, Inc. | 0 | US$0 | 0.00% |
| Neumora Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Apogee Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Lenz Therapeutics, Inc. | 0 | US$0 | 0.00% |