| Abbvie Inc. | 1.29M | US$324M | 14.7% |
| Gilead Sciences, Inc. | 964K | US$125M | 5.7% |
| Spyre Therapeutics, Inc. | 857K | US$84.3M | 3.8% |
| Alnylam Pharmaceuticals, Inc. | 387K | US$79.6M | 3.6% |
| Dianthus Therapeutics, Inc. | 730K | US$78.1M | 3.5% |
| Cogent Biosciences, Inc. | 1.83M | US$71.4M | 3.2% |
| Oruka Therapeutics, Inc. | 737K | US$71.2M | 3.2% |
| Insmed Incorporated | 680K | US$67.1M | 3.0% |
| Revolution Medicines, Inc. | 352K | US$66M | 3.0% |
| Argenx Se | 77,200 | US$65.9M | 3.0% |
| Ascendis Pharma A/s | 269K | US$65.7M | 3.0% |
| Biogen Inc. | 294K | US$59.7M | 2.7% |
| Mbx Biosciences, Inc. | 818K | US$53.9M | 2.5% |
| Amgen Inc. | 135K | US$52M | 2.4% |
| Amylyx Pharmaceuticals, Inc. | 2.43M | US$49.4M | 2.2% |
| Vaxcyte, Inc. | 802K | US$43.3M | 2.0% |
| Moderna, Inc. | 641K | US$35.1M | 1.6% |
| Relay Therapeutics, Inc. | 1.85M | US$34.8M | 1.6% |
| Viridian Therapeutics, Inc. | 1.78M | US$33.7M | 1.5% |
| Natera, Inc. | 117K | US$31.4M | 1.4% |
| Kiniksa Pharmaceuticals International, Plc | 418K | US$31M | 1.4% |
| Vertex Pharmaceuticals Incorporated | 63,900 | US$30.5M | 1.4% |
| Enliven Therapeutics, Inc. | 501K | US$27.5M | 1.2% |
| Alumis Inc. | 947K | US$26.7M | 1.2% |
| Roivant Sciences Ltd. | 777K | US$26.3M | 1.2% |
| Kymera Therapeutics, Inc. | 232K | US$24M | 1.1% |
| Praxis Precision Medicines, Inc. | 74,200 | US$22.8M | 1.0% |
| Xenon Pharmaceuticals Inc. | 342K | US$21.4M | 0.98% |
| Celldex Therapeutics, Inc. | 512K | US$19.5M | 0.89% |
| Regeneron Pharmaceuticals, Inc. | 22,500 | US$17.2M | 0.78% |
| Zenas Biopharma, Inc. | 492K | US$15.5M | 0.70% |
| First Tracks Biotherapeutics, Inc. | 341K | US$15M | 0.68% |
| Mirum Pharmaceuticals, Inc. | 135K | US$14.3M | 0.65% |
| Viking Therapeutics, Inc. | 450K | US$14.3M | 0.65% |
| Jade Biosciences, Inc. | 699K | US$13.8M | 0.63% |
| Newamsterdam Pharma Company N.v. | 448K | US$12.4M | 0.57% |
| Dyne Therapeutics, Inc. | 482K | US$12.1M | 0.55% |
| Climb Bio, Inc. | 996K | US$11.9M | 0.54% |
| Arcus Biosciences, Inc. | 418K | US$11.8M | 0.54% |
| Avalo Therapeutics, Inc. | 640K | US$11.7M | 0.53% |
| Tyra Biosciences, Inc. | 354K | US$11.3M | 0.51% |
| Cg Oncology, Inc. | 158K | US$11.2M | 0.51% |
| Uniqure N.v. | 224K | US$9.75M | 0.44% |
| Stoke Therapeutics, Inc. | 318K | US$9.17M | 0.42% |
| Olema Pharmaceuticals, Inc. | 777K | US$8.9M | 0.40% |
| Hemab Therapeutics Holdings, Inc. | 187K | US$8.88M | 0.40% |
| Annexon, Inc. | 1.66M | US$8.47M | 0.38% |
| Mineralys Therapeutics, Inc. | 331K | US$8.45M | 0.38% |
| Ucb S.a. | 32,600 | US$8.38M | 0.38% |
| Cytomx Therapeutics, Inc. | 2.49M | US$7.72M | 0.35% |
| Vor Biopharma Inc. | 344K | US$7.27M | 0.33% |
| Definium Therapeutics, Inc. | 161K | US$7.02M | 0.32% |
| Tarsus Pharmaceuticals, Inc. | 110K | US$6.49M | 0.30% |
| Disc Medicine, Inc. | 80,922 | US$6.23M | 0.28% |
| Tenax Therapeutics, Inc. | 445K | US$6.1M | 0.28% |
| Neurogene Inc. | 177K | US$5.83M | 0.26% |
| Dbv Technologies Sa | 429K | US$5.79M | 0.26% |
| Scholar Rock Holding Corporation | 118K | US$5.59M | 0.25% |
| Edgewise Therapeutics, Inc. | 145K | US$5.55M | 0.25% |
| Solid Biosciences Inc. | 678K | US$5.46M | 0.25% |
| Inflarx N.v. | 3.2M | US$5.43M | 0.25% |
| X4 Pharmaceuticals, Inc. | 1.34M | US$5.34M | 0.24% |
| Crescent Biopharma, Inc. | 356K | US$5.15M | 0.23% |
| Janux Therapeutics, Inc. | 320K | US$4.86M | 0.22% |
| Madrigal Pharmaceuticals, Inc. | 10,300 | US$4.81M | 0.22% |
| Avalyn Pharma Inc. | 162K | US$4.67M | 0.21% |
| Upstream Bio, Inc. | 691K | US$4.36M | 0.20% |
| Bridgebio Pharma, Inc. | 46,900 | US$3.76M | 0.17% |
| Kodiak Sciences Inc | 88,300 | US$3.67M | 0.17% |
| Contineum Therapeutics, Inc. | 225K | US$3.48M | 0.16% |
| Tectonic Therapeutic, Inc. | 121K | US$3.39M | 0.15% |
| Inventiva Sa | 685K | US$3.07M | 0.14% |
| Maplight Therapeutics, Inc. | 203K | US$2.64M | 0.12% |
| Taysha Gene Therapies, Inc. | 0 | US$0 | 0.00% |
| Travere Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Tango Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Crinetics Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Nuvalent, Inc. | 0 | US$0 | 0.00% |
| Axsome Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Veradermics, Incorporated | 0 | US$0 | 0.00% |
| Apogee Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Rhythm Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Cytokinetics, Incorporated | 0 | US$0 | 0.00% |
| Damora Therapeutics, Inc. | 0 | US$0 | 0.00% |