| Praxis Precision Medicines, Inc. | 2.04M | US$682M | 10.2% |
| Spyre Therapeutics, Inc. | 4.32M | US$383M | 5.8% |
| Celcuity Inc. | 3.2M | US$334M | 5.0% |
| Rhythm Pharmaceuticals, Inc. | 2.59M | US$287M | 4.3% |
| Roivant Sciences Ltd. | 8.09M | US$286M | 4.3% |
| Relay Therapeutics, Inc. | 14.1M | US$264M | 4.0% |
| Travere Therapeutics, Inc. | 3.75M | US$213M | 3.2% |
| Kardigan, Inc. | 8.2M | US$196M | 2.9% |
| Nuvalent, Inc. | 1.58M | US$195M | 2.9% |
| Edgewise Therapeutics, Inc. | 4.37M | US$178M | 2.7% |
| Apogee Therapeutics, Inc. | 1.31M | US$174M | 2.6% |
| Amylyx Pharmaceuticals, Inc. | 8.33M | US$150M | 2.2% |
| Meiragtx Holdings Plc | 10.8M | US$146M | 2.2% |
| Oruka Therapeutics, Inc. | 1.35M | US$128M | 1.9% |
| Inhibrx Biosciences, Inc. | 1.3M | US$123M | 1.8% |
| Protagonist Therapeutics, Inc. | 982K | US$120M | 1.8% |
| Solid Biosciences Inc. | 11.9M | US$119M | 1.8% |
| Zymeworks Inc. | 4.18M | US$109M | 1.6% |
| Tango Therapeutics, Inc. | 3.38M | US$106M | 1.6% |
| Nurix Therapeutics, Inc. | 4.32M | US$105M | 1.6% |
| Biocryst Pharmaceuticals, Inc. | 10.3M | US$103M | 1.5% |
| Revolution Medicines, Inc. | 528K | US$98.8M | 1.5% |
| Avalyn Pharma Inc. | 2.68M | US$88.1M | 1.3% |
| Dyne Therapeutics, Inc. | 2.69M | US$59.7M | 0.90% |
| Biogen Inc. | 276K | US$59.7M | 0.90% |
| Immunovant, Inc. | 1.36M | US$52.3M | 0.79% |
| Unitedhealth Group Incorporated | 117K | US$48.5M | 0.73% |
| Ionis Pharmaceuticals, Inc. | 566K | US$44.9M | 0.67% |
| Sutro Biopharma, Inc. | 1.3M | US$43.3M | 0.65% |
| Alto Neuroscience, Inc. | 1.61M | US$42.5M | 0.64% |
| Corvus Pharmaceuticals, Inc. | 2.67M | US$39.9M | 0.60% |
| Sionna Therapeutics, Inc. | 905K | US$39.8M | 0.60% |
| Cytomx Therapeutics, Inc. | 10.4M | US$39.1M | 0.59% |
| Artivion, Inc. | 1.74M | US$39M | 0.59% |
| X4 Pharmaceuticals, Inc. | 7.93M | US$37M | 0.56% |
| Corcept Therapeutics Incorporated | 398K | US$34.6M | 0.52% |
| Repligen Corporation | 248K | US$33.9M | 0.51% |
| Anteris Technologies Global Corp. | 3.43M | US$33.7M | 0.51% |
| Rapport Therapeutics, Inc. | 773K | US$32.2M | 0.48% |
| Damora Therapeutics, Inc. | 1.22M | US$31.8M | 0.48% |
| Charles River Laboratories International, Inc. | 140K | US$31.8M | 0.48% |
| Axsome Therapeutics, Inc. | 118K | US$29M | 0.44% |
| Dbv Technologies Sa | 1.65M | US$27.1M | 0.41% |
| Irhythm Holdings, Inc. | 224K | US$26.6M | 0.40% |
| Adaptive Biotechnologies Corporation | 1.22M | US$26.1M | 0.39% |
| Sab Biotherapeutics, Inc. | 6.63M | US$25.8M | 0.39% |
| Danaher Corporation | 130K | US$24.8M | 0.37% |
| Tenax Therapeutics, Inc. | 1.7M | US$24.7M | 0.37% |
| Nautilus Biotechnology, Inc. | 11.6M | US$21.8M | 0.33% |
| Orchestra Biomed Holdings, Inc. | 5.04M | US$21.7M | 0.33% |
| Intuitive Surgical, Inc. | 51,884 | US$20.6M | 0.31% |
| Contineum Therapeutics, Inc. | 1.26M | US$20.6M | 0.31% |
| Nuvectis Pharma, Inc. | 1M | US$18.4M | 0.28% |
| Palisade Bio, Inc. | 8.43M | US$17.6M | 0.26% |
| Omada Health, Inc. | 786K | US$17.3M | 0.26% |
| Leonabio, Inc. | 1.86M | US$17.1M | 0.26% |
| Evolus, Inc. Common Stock | 2.46M | US$17.1M | 0.26% |
| Invivyd, Inc. | 18.5M | US$16.1M | 0.24% |
| Mirum Pharmaceuticals, Inc. | 115K | US$13.5M | 0.20% |
| Surrozen, Inc. | 504K | US$13.1M | 0.20% |
| Beta Bionics, Inc. | 833K | US$13.1M | 0.20% |
| Axogen, Inc. | 247K | US$11.4M | 0.17% |
| Oscar Health, Inc. | 400K | US$11.4M | 0.17% |
| Seaport Therapeutics, Inc. | 500K | US$10.9M | 0.16% |
| Viridian Therapeutics, Inc. | 582K | US$10.7M | 0.16% |
| Boston Scientific Corporation | 250K | US$10.7M | 0.16% |
| Billiontoone, Inc. | 86,812 | US$10.4M | 0.16% |
| Abivax Sa | 74,000 | US$9.86M | 0.15% |
| Natera, Inc. | 34,689 | US$9.42M | 0.14% |
| Research Alliance Corporation Iii | 750K | US$8.03M | 0.12% |
| Cullinan Therapeutics, Inc. | 426K | US$7.77M | 0.12% |
| Mobia Medical, Inc. | 524K | US$7.02M | 0.11% |
| Adagio Medical Holdings, Inc | 9.88M | US$6.44M | 0.10% |
| Guardant Health, Inc. | 41,327 | US$6.2M | 0.09% |
| Phathom Pharmaceuticals, Inc. | 532K | US$5.77M | 0.09% |
| Outlook Therapeutics, Inc. | 3.14M | US$4.99M | 0.07% |
| Cogent Biosciences, Inc. | 121K | US$4.69M | 0.07% |
| Edesa Biotech, Inc. | 563K | US$4.58M | 0.07% |
| Avalo Therapeutics, Inc. | 220K | US$4.06M | 0.06% |
| Twist Bioscience Corporation | 36,812 | US$3.79M | 0.06% |
| Crescent Biopharma, Inc. | 207K | US$3.72M | 0.06% |
| Xeris Biopharma Holdings, Inc. | 467K | US$3.7M | 0.06% |
| Outset Medical, Inc. | 833K | US$3.6M | 0.05% |
| Biodesix, Inc. | 109K | US$2.45M | 0.04% |
| Connect Biopharma Holdings Limited | 793K | US$1.89M | 0.03% |
| Kiora Pharmaceuticals, Inc. | 438K | US$1.15M | 0.02% |
| Medline Inc. | 28,000 | US$1.1M | 0.02% |
| Adma Biologics Inc | 114K | US$952K | 0.01% |
| Cumberland Pharmaceuticals Inc. | 96,982 | US$628K | <0.01% |
| Exagen Inc. | 115K | US$534K | <0.01% |
| Ensysce Biosciences, Inc. | 86,666 | US$25,133 | <0.01% |
| Neurocrine Biosciences, Inc. | 0 | US$0 | 0.00% |
| Opus Genetics, Inc. | 0 | US$0 | 0.00% |
| Palatin Technologies, Inc. | 0 | US$0 | 0.00% |
| Apellis Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Ascendis Pharma A/s | 0 | US$0 | 0.00% |
| Bright Minds Biosciences Inc. | 0 | US$0 | 0.00% |
| Engene Holdings Inc. | 0 | US$0 | 0.00% |
| Evommune, Inc. | 0 | US$0 | 0.00% |
| Inhibikase Therapeutics, Inc. | 0 | US$0 | 0.00% |