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TR-1

Octopus Investments Limited has reduced its holding in Itaconix PLC, with its total voting rights now standing at 8.81%, representing 1,188,646 voting rights. This follows a previous notification where the holding was 9.84%. The change occurred on January 23, 2026, and was notified to the issuer on January 26, 2026. Disclaimer*

Itaconix PlcJanuary 28, 20264
TR-1

About this update from Itaconix Plc

TR-1: Standard form for notification of major holdings 1. Issuer Details ISIN GB00BPK3YZ68 Issuer Name ITACONIX PLC UK or Non-UK Issuer UK 2. Reason for Notification An acquisition or disposal of voting rights 3. Details of person subject to the notification obligation Name Octopus Investments Limited City of registered office (if applicable) London Country of registered office (if applicable) England 4. Details of the shareholder Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above   City of registered office (if applicable)   Country of registered office (if applicable)   5. Date on which the threshold was crossed or reached 23-Jan-2026 6. Date on which Issuer notified 26-Jan-2026 7. Total positions of person(s) subject to the notification obligation % of voting rights attached to shares (total of 8.A) % of voting rights through financial instruments (total of 8.B 1 + 8.B 2) Total of both in % (8.A + 8.B) Total number of voting rights held in issuer Resulting situation on the date on which threshold was crossed or reached 8.810000 0.000000 8.810000 1188646 Position of previous notification (if applicable) 9.840000 0.000000 9.840000 8. Notified details of the resulting situation on the date on which the threshold was crossed or reached 8A. Voting rights attached to shares Class/Type of shares ISIN code(if possible) Number of direct voting rights (DTR5.1) Number of indirect voting rights (DTR5.2.1) % of direct voting rights (DTR5.1) % of indirect voting rights (DTR5.2.1) GB00BPK3YZ68 0 1188646 0.000000 8.810000 Sub Total 8.A 1188646 8.810000% 8B1. Financial Instruments according to (DTR5.3.1R.(1) (a)) Type of financial instrument Expiration date Exercise/conversion period Number of voting rights that may be acquired if the instrument is exercised/converted % of voting rights   Sub Total 8.B1 8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b)) Type of financial instrument Expiration date Exercise/conversion period Physical or cash settlement Number of voting rights % of voting rights   Sub Total 8.B2 9. Information in relation to the person subject to the notification obligation 2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary) Ultimate controlling person Name of controlled undertaking % of voting rights if it equals or is higher than the notifiable threshold % of voting rights through financial instruments if it equals or is higher than the notifiable threshold Total of both if it equals or is higher than the notifiable threshold Octopus Capital Limited Octopus Investments Limited 8.810000 0.000000 8.810000% 10. In case of proxy voting Name of the proxy holder   The number and % of voting rights held   The date until which the voting rights will be held   11. Additional Information   12. Date of Completion 26/01/2026 13. Place Of Completion 33 Holborn, EC1N 2HT

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