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Sino Biological's Cell-Free Protein Synthesis Supports Tencent AI for Life Sciences Lab's Protein Design Study Published in Nature Communications
HOUSTON, TEXAS - May 28, 2026 (NEWMEDIAWIRE) - Sino Biological, Inc. (Shenzhen Stock Exchange: 301047.SZ) has announced that its gene synthesis and cell-free protein expression workflow was used in a recent study by Tencent AI for Life Sciences Lab p...
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[{"type":"text","content":"HOUSTON, TEXAS - May 28, 2026 (NEWMEDIAWIRE) - Sino Biological, Inc. (Shenzhen Stock Exchange: 301047.SZ) has announced that its gene synthesis and cell-free protein expression workflow was used in a recent study by Tencent AI for Life Sciences Lab published in Nature Communications, enabling rapid experimental validation of AI-designed proteins with improved activity, stability, and multifunctionality.","length":406,"tagName":"p"},{"type":"text","content":"Bridging AI Protein Design and Experimental Validation","length":54,"tagName":"p"},{"type":"text","content":"Artificial intelligence has significantly accelerated protein amino acid sequence design, however, translating these computational designs into functional proteins remains a key challenge in protein engineering. Protein activity, stability, folding, and expression are influenced by complex structural and biochemical factors, often leading to discrepancies between in silico predictions and experimental outcomes.","length":414,"tagName":"p"},{"type":"text","content":"To address this gap, the study introduced an Ontology Reinforcement Iteration (ORI) framework, integrating protein ontology with reinforcement learning from wet-lab feedback. Experimental data, including protein expression levels and functional activity, were continuously fed back into the model enabling iterative optimization of protein sequences and improved design accuracy.","length":379,"tagName":"p"},{"type":"text","content":"Cell-Free Protein Synthesis Accelerates the AI Design Loop","length":58,"tagName":"p"},{"type":"text","content":"The researchers subsequently utilized Sino Biological's XPressMAX(TM) Cell-Free Protein Synthesis Kit to enable rapid protein expression and functional screening. Protein-coding sequences cloned into the kit's expression vector and added to the proprietary cell-free reaction system supported rapid design–build–test cycles.","length":332,"tagName":"p"},{"type":"text","content":"Using this workflow, the team engineered a lysozyme with over 100-fold higher activity than the natural enzyme, developed a thermostable chitinase retaining activity at 85C, and successfully expressed bifunctional enzymes with improved performance compared with naturally occurring multifunctional enzymes.","length":306,"tagName":"p"},{"type":"text","content":"XPressMAX(TM)Cell-Free Protein ...