PolyPid Provides Corporate Update and Reports Second Quarter 2025 Financial Results

About this update from Polypid Ltd.

Positive Phase 3 SHIELD II Trial Results - D-PLEX₁₀₀ successfully met its primary efficacy endpoint and demonstrated 58% reduction in SSI NDA submission expected in Q1 2026 Unveil ed a Long-Acting GLP-1 Receptor Agonists Delivery Platform Targeting the O besity and Diabetes Market Successful Warrant Exercise Significantly Strengthened Balance Sheet with Cash Runway into 2026 Conference Call Scheduled for Today at 8:30 AM ET PETACH TIKVA, Israel, Aug. 13, 2025 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) ("PolyPid" or the "Company"), a late-stage biopharma company aiming to improve surgical outcomes, today provided a corporate update and reported financial results for the three and six months ended June 30, 2025. Recent Corporate Highlights: "The second quarter of 2025 was transformational for PolyPid with the successful completion of our SHIELD II Phase 3 trial, which demonstrated significant clinical benefits of D-PLEX₁₀₀ in preventing SSIs in abdominal colorectal surgeries," stated Dikla Czaczkes Akselbrad, PolyPid's Chief Executive Officer. "The positive data has generated substantial interest from potential commercial partners and reinforced our conviction in D-PLEX₁₀₀'s potential to address a significant unmet medical need." "Moreover, we are extremely encouraged by the enthusiastic reception from healthcare professionals who recognize the potential of D-PLEX₁₀₀ to substantially reduce the burden of SSIs, improve patient outcomes, and generate meaningful healthcare cost savings," continued Ms. Czaczkes Akselbrad. "With our strengthened balance sheet and multiple strategic options before us, we are well-positioned to maximize the value of our innovative technology." Financial results for three months ended June 30, 2025 Financial results for six months ended June 30, 2025 Balance Sheet Highlights Conference Call Dial-In & Webcast Information: About PolyPid PolyPid Ltd. (Nasdaq:  PYPD ) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid's proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. Following positive phase 3 results, New Drug Application (NDA) submission of D-PLEX₁₀₀, PolyPid's lead product candidate, for the prevention of abdominal colorectal surgical site infections, is expected in early 2026. In addition, the Company has an innovative pipeline in oncology, obesity and diabetes. For additional Company information, please visit  http://www.polypid.com  and follow us on  Twitter (X)  and  LinkedIn . Forward-looking Statements This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates" and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses D-PLEX₁₀₀'s potential clinical benefits, the expected NDA submission and its timing, its commercialization preparations and strategic partnership discussions to maximize D-PLEX₁₀₀'s market potential, the aims of GLP-1 program, the Company's potential commercial partners, D-PLEX₁₀₀'s potential to address a significant unmet medical need, the Company's ability to maximize the value of its innovative technology and the Company's expectation that its current cash runway will be sufficient well into 2026. Forward-looking statements are not historical facts, and are based upon management's current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management's expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company's reports filed from time to time with the Securities and Exchange Commission, including, but not limited to, the risks detailed in the Company's Annual Report on Form 20-F filed on February 26, 2025. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites. Company Contact: PolyPid Ltd.  Ori Warshavsky 908-858-5995 [email protected] Investor & IR Contact: Arx | Capital Markets North American Equities Desk [email protected]

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