MitoCareX Bio completes comprehensive SLC transport protein analysis to support discovery of small molecules for hard-to-treat cancers and inflammatory metabolic diseases and enters an AI-driven small-molecule discovery initiative with Boltz
Ness Ziona, Israel, July 07, 2026 (GLOBE NEWSWIRE) -- Nexentis Technologies Inc. ("Nexentis"), (NASDAQ: NXTS) ("Nexentis" or the "Company"), a drug discovery company that also invests in solar energy assets based on the RTB (Ready to Build) business model, has recently reported that its wholly owned subsidiary, MitoCareX Bio Ltd. ("MitoCareX Bio"), successfully completed a broad analysis of SLC transport proteins and initiated an international AI drug discovery initiative with Boltz, PBC ("Boltz"), to accelerate the discovery of novel small-molecule modulators of these targets.
SLC analysis achievement
MitoCareX Bio's recently completed analysis builds on MITOLINE®, its proprietary sequence analysis and alignment algorithm, which to date has been used to prepare mitochondrial SLC carrier proteins for reliable structural modeling in support of structure-based drug discovery in hard-to-treat cancers and inflammatory metabolic diseases. Based on this new analysis, MitoCareX Bio has identified additional SLC proteins outside the mitochondrial SLC25 family whose amino acid sequences appear compatible with the MITOLINE® ruleset, suggesting that these transporters may also be amenable to MITOLINE®-enabled structural modeling. This analysis represents an important step in MitoCareX Bio's strategy to expand and refine its small-molecule discovery capabilities into additional disease-relevant transport proteins.
International AI initiative with Boltz
In parallel, Nexentis Technologies announced an international AI drug discovery initiative between MitoCareX Bio and Boltz, an AI research lab that focuses on biomolecular foundation models and drug discovery workflows. Boltz describes Boltz Lab as a hosted platform that combines biomolecular foundation models, managed compute, and scientist-oriented workflows, and has publicly highlighted the deployment of its models with industry partners, including a strategic collaboration with Pfizer and Takeda. BoltzMol-1, the company's small-molecule generative pipeline is designed to model complex structures and binding affinities and support in silico screening and design of small-molecule for drug discovery programs.
Under this initiative, MitoCareX Bio intends to combine its proprietary MITOLINE® algorithm platform and Boltz's foundation models for predicting biomolecular structure and binding affinity and designing new molecules - two complementary and independently validated capabilities. With this combination of systematic SLC analysis and AI-enabled capabilities, MitoCareX aims to enhance the efficiency of identifying and progressing novel drug candidates directed at SLC transport proteins previously analyzed by MitoCareX Bio.