Kura Oncology to Present First Long-Term Follow-Up Data Further Supporting Darlifarnib’s Potential to Enhance VEGFR-Targeted Therapy in Renal Cell Carcinoma at KCRS 2026

About this update from Kura Oncology, Inc.

– Oral presentation will feature updated data from the FIT-001 Phase 1a study of darlifarnib plus cabozantinib in cabozantinib-naïve, advanced ccRCC patients – – Updated data expected to support darlifarnib's potential to enhance VEGFR-targeted therapy in ccRCC – – Global randomized Phase 1b study comparing darlifarnib plus cabozantinib versus cabozantinib alone is ongoing – – Results continue to support darlifarnib as a precision combination agent across multiple targeted therapy classes – – Virtual investor call on July 27, 2026 at 5:00 a.m. PT / 8:00 a.m. ET – SAN DIEGO, July 14, 2026 (GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a biopharmaceutical company focused on precision medicines for the treatment of cancer, today announced that updated Phase 1a results from the ongoing FIT-001 Phase 1a/1b clinical trial ( NCT06026410) evaluating darlifarnib in combination with cabozantinib in advanced renal cell carcinoma (RCC) will be featured in an oral presentation at the 2026 Kidney Cancer Research Summit (KCRS) in Boston. The presentation will highlight long-term follow-up results in heavily pretreated cabozantinib-naïve patients with refractory RCC, providing further evidence of darlifarnib's potential as a combination agent with VEGFR-targeted therapies, a widely used treatment approach in this patient population. RCC is the most common form of kidney cancer, and clear cell RCC (ccRCC) is the most common histology in RCC, accounting for more than 61,000 new cases in the U.S. each year.1 "Despite meaningful advances in the treatment of renal cell carcinoma, there remains a significant need for combination strategies capable of delivering deeper and more durable responses," said Mollie Leoni, M.D., Chief Medical Officer of Kura Oncology. "The updated FIT-001 data will further inform the potential of darlifarnib plus cabozantinib as a precision combination strategy in advanced ccRCC. More broadly, Kura's KCRS presentation builds on the growing body of clinical evidence supporting darlifarnib's mechanism of action across VEGF-TKI, KRAS and PI3Ka inhibitor combinations, supporting darlifarnib's potential to enhance clinical activity of these targeted-therapy backbones." The KCRS presentation adds to the FIT-001 RCC results presented at ESMO 2025 and additional findings in cabozantinib-exposed ccRCC patients presented at 2026 IKCS: Europe. Kura is currently enrolling patients in the U.S. and E.U. in the randomized Phase 1b dose-optimization portion of FIT-001 in cabozantinib-naïve, refractory, advanced ccRCC. The randomized Phase 1b portion is evaluating darlifarnib plus cabozantinib versus cabozantinib alone and is designed to inform selection of a recommended Phase 3 dose for a registrational study planned for 2028.

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