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Kura Oncology Highlights Darlifarnib’s Potential as a Foundational Combination Platform for KRAS-Mutant Cancers and Outlines Development Strategy
– Preliminary Phase 1a data from darlifarnib + adagrasib demonstrate confirmed, objective response rates of 67% in pancreatic cancer, 50% in non-small cell lung cancer, and 29% in KRAS inhibitor-naïve colorectal cancer patients – – Clinical activity observed in both KRAS inhibitor-naïve and KRAS inhibitor-pretreated patients – – Preclinical data support broad applicability across the evolving RAS inhibitor landscape, including mutant-selective, pan-KRAS and RAS(ON) multi-selective inhibitors – –
About this update from Kura Oncology, Inc.
– Preliminary Phase 1a data from darlifarnib + adagrasib demonstrate confirmed, objective response rates of 67% in pancreatic cancer, 50% in non-small cell lung cancer, and 29% in KRAS inhibitor-naïve colorectal cancer patients – – Clinical activity observed in both KRAS inhibitor-naïve and KRAS inhibitor-pretreated patients – – Preclinical data support broad applicability across the evolving RAS inhibitor landscape, including mutant-selective, pan-KRAS and RAS(ON) multi-selective inhibitors – – New platform study designed to accelerate evaluation of darlifarnib across multiple targeted therapies, combinations, and disease settings – – First planned platform combination, darlifarnib + daraxonrasib in KRAS-mutant pancreatic cancer, expected to enter Phase 1a evaluation in early 2027 – – Kura to host virtual investor event on June 3, 2026, at 12:15 p.m. PT / 3:15 p.m. ET to discuss darlifarnib data, platform strategy, and development plans – SAN DIEGO, June 03, 2026 (GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a biopharmaceutical company focused on precision medicines for the treatment of cancer, today highlighted new clinical and translational data supporting darlifarnib as a potential foundational combination platform for KRAS-mutant cancers and other targeted therapy settings. The data, presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, support Kura’s strategy to expand its next-generation farnesyl transferase inhibitor (FTI) through a new platform study designed to efficiently evaluate multiple combinations and identify opportunities to improve the depth and durability of responses to targeted therapies. “Today's data release and strategic update reinforce our belief that darlifarnib represents much more than a single combination opportunity,” said Troy E. Wilson, Ph.D., J.D., President and Chief Executive Officer of Kura Oncology. “With FTI clinical proof-of-concept now demonstrated in three distinct targeted therapy settings, and translational data supporting applicability across the evolving RAS inhibitor landscape, we believe darlifarnib has the potential to become a foundational combination backbone for molecularly defined cancers. Our planned platform study is designed to accelerate development across multiple combinations and disease settings, beginning with darlifarnib plus darax...
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