KRTL Holding Group, Inc. Announces Exclusive Distribution and Commercialization Agreement With Star Pharmaceuticals

About this update from Krtl Holding Group, Inc

KRTL Holding Group, Inc. (OTC: KRTL) (“KRTL” or the “Company”), today announced that its wholly owned subsidiary, KRTL Biotech, Inc. (“KRTL Biotech”), has entered into a Distribution, Supply and Promotion Agreement with Star Pharmaceuticals, LLC (“STAR”). Under the terms of the arrangement, KRTL Biotech obtained exclusive rights, subject to performance requirements, to commercialize, distribute, and promote certain non-prescription formulations within the United States, Central America, South America, the Caribbean, and Thailand. The arrangement has an initial five-year term and includes a revenue-sharing structure tied to net sales. This strategic collaboration positions KRTL Biotech within a growing segment of the broader health and wellness and specialty product markets, where demand for differentiated formulations, alternative delivery formats, and internationally scalable distribution platforms continues to evolve. The Company believes this structure enables participation in emerging product categories while maintaining a disciplined, compliance-first operating model. The framework also provides for KRTL Biotech to oversee regulatory coordination, market development, distribution, and promotional activities, while utilizing third-party manufacturing partners operating under applicable current Good Manufacturing Practice (cGMP) standards. STAR will contribute product-related intellectual property and technical support under an exclusive license within the defined field. “This represents a disciplined but important expansion of our commercial strategy,” said Cesar Herrera, CEO of KRTL Holding Group and KRTL Biotech. “We are entering a category that continues to attract market interest, while applying a controlled approach centered on regulatory alignment, supply chain structure, and scalable distribution.” Methylene blue and related compounds have a long history of use across medical and research settings and are now seeing renewed commercial interest within broader health and specialty product markets. The Company believes evolving consumer awareness, new delivery formats, and expanding global distribution channels are contributing to increasing market attention, subject to applicable regulatory frameworks. The collaboration is expected to focus initially on non-prescription product formats, including capsule and gummy formulations. These delivery formats are increasingly prevalent across consumer-facing health and wellness markets, offering potential for differentiated positioning, retail accessibility, and cross-border distribution strategies, subject to applicable regulatory frameworks. “This represents an important first step in what we believe can become a broader and strategically aligned relationship,” said Roseanne Branciforte, Co-Founder and CEO of Star Pharmaceuticals. “By combining STAR’s established product portfolio, including Urolene Blue®—a prescription-only product first introduced in 1973—with KRTL Biotech’s commercialization platform, we are creating a foundation for potential future expansion as market opportunities evolve, subject to regulatory and commercial conditions.” The Company cautions that commercialization activities, revenue generation, and market expansion remain subject to a range of factors, including regulatory approvals, supply chain execution, market acceptance, and compliance with applicable laws and regulations.   About KRTL Holding Group, Inc. KRTL Holding Group, Inc. (OTC: KRTL) operates through its subsidiaries KRTL Biotech, Inc. and KRTL International Corp. The Company leverages strategic synergies across biotech, technology, and emerging markets to drive growth and deliver shareholder value. About KRTL Biotech, Inc. KRTL Biotech, Inc. focuses on building scalable life-science operations that prioritize quality, compliance, and innovation. The company aims to expand its international footprint while maintaining rigorous U.S. reporting and regulatory standards. About Star Pharmaceuticals, LLC Star Pharmaceuticals, LLC is a U.S.-based company engaged in the development and commercialization of specialty pharmaceutical and wellness products, with a focus on proprietary formulations and intellectual property. For more information: www.krtlholding.com | www.krtl-icc.com | www.krtlbiotech.com | www.starpharm.com/   Forward-Looking Statements This press release contains statements and information that, to the extent that they are not historical fact, may constitute   “forward-looking statements” within the meaning of applicable securities legislation. These statements relate to future events or our future financial performance and involve known and unknown risks, uncertainties, and other factors that may cause our actual results, performance, or achievements to differ materially from any future results, performance, or achievements expressed or implied by these forward-looking statements. Words such as “anticipates,” “will,” “believes,” “plans,” “expects,” “intends,” “projects,” “estimates,” “future,” and “opportunity” and similar expressions are used to identify these forward-looking statements. Forward-looking statements are not guarantees of future performance. Examples of such statements include, but are not limited to, statements with respect to the objectives and business plans of the Company; ability to realize benefits from its recent corporate appointments and acquisitions; ability to retain its key personnel; the intention to grow the Company’s business and operations; the competitive conditions of the industries in which the Company operates; and laws and any amendments thereto applicable to the Company. Forward-looking information is based on the assumptions, estimates, analysis and opinions of management made in light of its experience and its perception of trends, current conditions and expected developments, as well as other factors that management believes to be relevant and reasonable in the circumstances at the date that such statements are made, but which may prove to be incorrect. Forward-looking information involves known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of the Company to differ materially from any future results, performance or achievements expressed or implied by the forward-looking information, including, without limitation, risks relating to the future business plans of the Company; risks that the Company will not be able to retain its key personnel; risks that the Company will not be able to secure financing on reasonable terms or at all, as well as all of the other risks. Accordingly, readers should not place undue reliance on any such forward-looking information. Further, any forward-looking information speaks only as of the date on which such statement is made. New factors emerge from time to time, and it is not possible for the Company’s management to predict all of such factors and to assess in advance the impact of each such factor on the Company’s business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking information. The Company does not undertake any obligation to update any forward-looking information to reflect information or events after the date on which it is made or to reflect the occurrence of unanticipated events, except as required by law.

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