| Krystal Biotech, Inc. | 1.8M | US$557M | 10.6% |
| Abbvie Inc. | 2.23M | US$486M | 9.2% |
| Amgen Inc. | 1.02M | US$344M | 6.5% |
| Gilead Sciences, Inc. | 1.89M | US$254M | 4.8% |
| Alnylam Pharmaceuticals, Inc. | 512K | US$155M | 2.9% |
| Praxis Precision Medicines, Inc. | 371K | US$130M | 2.5% |
| Insmed Incorporated | 1.11M | US$119M | 2.3% |
| Argenx Se | 141K | US$118M | 2.2% |
| Ascendis Pharma A/s | 480K | US$108M | 2.0% |
| Revolution Medicines, Inc. | 675K | US$106M | 2.0% |
| Ucb S.a. | 358K | US$105M | 2.0% |
| Jazz Pharmaceuticals Plc | 410K | US$97.1M | 1.8% |
| Scholar Rock Holding Corporation | 1.65M | US$81.4M | 1.5% |
| Natera, Inc. | 332K | US$74.1M | 1.4% |
| Moderna, Inc. | 1.43M | US$67.6M | 1.3% |
| Axsome Therapeutics, Inc. | 287K | US$67.2M | 1.3% |
| Biogen Inc. | 339K | US$66.4M | 1.3% |
| Protagonist Therapeutics, Inc. | 608K | US$60.5M | 1.1% |
| Roivant Sciences Ltd. | 1.98M | US$59.5M | 1.1% |
| Cogent Biosciences, Inc. | 1.6M | US$56.1M | 1.1% |
| Tango Therapeutics, Inc. | 2.34M | US$51.4M | 0.98% |
| Celcuity Inc. | 376K | US$49.9M | 0.95% |
| Madrigal Pharmaceuticals, Inc. | 98,095 | US$48.8M | 0.93% |
| Bridgebio Pharma, Inc. | 707K | US$46.9M | 0.89% |
| Immunome, Inc. | 2.13M | US$46.5M | 0.88% |
| United Therapeutics Corporation | 82,591 | US$46M | 0.87% |
| Kymera Therapeutics, Inc. | 556K | US$45.3M | 0.86% |
| Arrivent Biopharma, Inc. | 1.44M | US$43.6M | 0.83% |
| Candel Therapeutics, Inc. | 4.86M | US$40.4M | 0.77% |
| Stoke Therapeutics, Inc. | 1.29M | US$40M | 0.76% |
| Dianthus Therapeutics, Inc. | 421K | US$39.1M | 0.74% |
| Travere Therapeutics, Inc. | 799K | US$37.7M | 0.72% |
| Ionis Pharmaceuticals, Inc. | 476K | US$36.4M | 0.69% |
| Dyne Therapeutics, Inc. | 1.88M | US$36.4M | 0.69% |
| Galderma Group Ag | 169K | US$35.7M | 0.68% |
| Corcept Therapeutics Incorporated | 507K | US$35.2M | 0.67% |
| Cytokinetics, Incorporated | 449K | US$34.5M | 0.65% |
| Abivax Sa | 255K | US$33.9M | 0.64% |
| Trevi Therapeutics, Inc. | 2.37M | US$33.6M | 0.64% |
| Oruka Therapeutics, Inc. | 563K | US$32.9M | 0.63% |
| Apogee Therapeutics, Inc. | 399K | US$32.7M | 0.62% |
| Erasca, Inc. | 2.53M | US$32.5M | 0.62% |
| Arrowhead Pharmaceuticals, Inc. | 409K | US$31.9M | 0.61% |
| Disc Medicine, Inc. | 455K | US$31.6M | 0.60% |
| Crinetics Pharmaceuticals, Inc. | 887K | US$31.5M | 0.60% |
| Kiniksa Pharmaceuticals International, Plc | 638K | US$30.8M | 0.59% |
| Nuvalent, Inc. | 273K | US$30.2M | 0.57% |
| Spyre Therapeutics, Inc. | 403K | US$29.6M | 0.56% |
| Annexon, Inc. | 5.08M | US$27.5M | 0.52% |
| Intellia Therapeutics, Inc. | 1.91M | US$26.9M | 0.51% |
| Vaxcyte, Inc. | 475K | US$24.4M | 0.46% |
| Edgewise Therapeutics, Inc. | 699K | US$23.9M | 0.45% |
| Viridian Therapeutics, Inc. | 1.31M | US$23.1M | 0.44% |
| Arcus Biosciences, Inc. | 853K | US$21.6M | 0.41% |
| Viatris Inc. | 1.29M | US$21M | 0.40% |
| Allogene Therapeutics, Inc. | 9.55M | US$20.7M | 0.39% |
| Bicara Therapeutics Inc. | 945K | US$20.6M | 0.39% |
| Maze Therapeutics, Inc. | 740K | US$19.6M | 0.37% |
| Zealand Pharma A/s | 378K | US$19.2M | 0.36% |
| Solid Biosciences Inc. | 2.61M | US$19.1M | 0.36% |
| Xenon Pharmaceuticals Inc. | 346K | US$18.9M | 0.36% |
| Ideaya Biosciences, Inc. | 638K | US$18.8M | 0.36% |
| Summit Therapeutics Inc. | 1.07M | US$18.7M | 0.36% |
| Vor Biopharma Inc. | 1.19M | US$17.8M | 0.34% |
| Newamsterdam Pharma Company N.v. | 524K | US$17.6M | 0.33% |
| Mirum Pharmaceuticals, Inc. | 171K | US$17.3M | 0.33% |
| Rapport Therapeutics, Inc. | 428K | US$16.9M | 0.32% |
| Twist Bioscience Corporation | 239K | US$16M | 0.30% |
| Biohaven Ltd. | 1.45M | US$16M | 0.30% |
| Amylyx Pharmaceuticals, Inc. | 1.1M | US$15.7M | 0.30% |
| Mannkind Corporation | 4.08M | US$15.4M | 0.29% |
| Kailera Therapeutics, Inc. | 619K | US$14.2M | 0.27% |
| Relay Therapeutics, Inc. | 1.01M | US$14.2M | 0.27% |
| Uniqure N.v. | 473K | US$13.5M | 0.26% |
| Enliven Therapeutics, Inc. | 340K | US$13.5M | 0.26% |
| Alumis Inc. | 620K | US$13.4M | 0.25% |
| Viking Therapeutics, Inc. | 404K | US$13.2M | 0.25% |
| Replimune Group, Inc. | 1.51M | US$13.2M | 0.25% |
| Tectonic Therapeutic, Inc. | 405K | US$12.6M | 0.24% |
| Idorsia Ltd. | 2.17M | US$12.4M | 0.24% |
| Mineralys Therapeutics, Inc. | 386K | US$12.2M | 0.23% |
| Ptc Therapeutics, Inc. | 160K | US$11.8M | 0.22% |
| Damora Therapeutics, Inc. | 455K | US$11.3M | 0.21% |
| Tyra Biosciences, Inc. | 337K | US$11.3M | 0.21% |
| Hemab Therapeutics Holdings, Inc. | 379K | US$10.8M | 0.21% |
| Forte Biosciences, Inc. | 564K | US$10.7M | 0.20% |
| Eikon Therapeutics, Inc. | 974K | US$10.6M | 0.20% |
| Absci Corporation | 1.54M | US$10.4M | 0.20% |
| Capricor Therapeutics, Inc. | 334K | US$10M | 0.19% |
| Cytomx Therapeutics, Inc. | 2.77M | US$9.99M | 0.19% |
| Gubra A/s | 166K | US$9.26M | 0.18% |
| Immunovant, Inc. | 272K | US$9.06M | 0.17% |
| Rhythm Pharmaceuticals, Inc. | 99,803 | US$8.81M | 0.17% |
| Vtv Therapeutics Inc. | 260K | US$8.68M | 0.16% |
| Beone Medicines Ltd. Class A | 29,698 | US$8.55M | 0.16% |
| Nuvation Bio Inc. | 1.76M | US$8.41M | 0.16% |
| Hansa Biopharma Ab | 2.29M | US$8.36M | 0.16% |
| Olema Pharmaceuticals, Inc. | 628K | US$8.28M | 0.16% |
| Beam Therapeutics Inc. | 245K | US$8.07M | 0.15% |
| Cg Oncology, Inc. | 129K | US$8.02M | 0.15% |