Healthcare
Zura Bio Exceeds Enrollment Target in Both Hidradenitis Suppurativa (HS) & Systemic Sclerosis (SSc) Phase 2 Studies and Expands Tibulizumab Program
HENDERSON, Nev., June 29, 2026--Zura Bio Limited (Nasdaq: ZURA) ("Zura"), a clinical stage biotechnology company developing novel and differentiated medicines to meaningfully improve the lives of patients with serious and debilitating autoimmune and inflammatory diseases, today announced several tibulizumab program updates.
About this update from Zura Bio Limited
HENDERSON, Nev., June 29, 2026--(BUSINESS WIRE)--Zura Bio Limited (Nasdaq: ZURA) ("Zura"), a clinical stage biotechnology company developing novel and differentiated medicines to meaningfully improve the lives of patients with serious and debilitating autoimmune and inflammatory diseases, today announced several tibulizumab program updates. Zura has completed enrollment of the Phase 2 TibuSHIELD trial of tibulizumab in adults with HS. The TibuSHIELD trial exceeded the target enrollment, with 247 participants enrolled. Zura remains on track to complete enrollment of the Phase 2 TibuSURE trial of tibulizumab in adults with early diffuse cutaneous SSc in early July. The TibuSURE trial has already exceeded the target enrollment of 80 participants. Exceeding enrollment targets in both TibuSHIELD and TibuSURE reflects the significant unmet need facing patients with HS and SSc. Topline data from TibuSHIELD are expected in the fourth quarter of 2026. Topline data from TibuSURE are expected in H1 2027. Building on tibulizumab's bispecific mechanism targeting both interleukin-17 ("IL-17") and B cell activating factor ("BAFF"), Zura plans to initiate a Phase 2 study in a third immune-mediated indication by year end 2026. Indication expansion of tibulizumab reflects Zura's belief in the broad potential of IL-17 and BAFF dual pathway inhibition across immune-mediated diseases. Zura plans to announce the new indication prior to study initiation. "Meeting these enrollment milestones reflects the hard work of our team and the commitment of the investigators and patients. Tibulizumab targets both IL-17 and BAFF — pathways that together form a compelling rationale across a range of immune-mediated conditions and that we believe can break through efficacy ceilings in complex immune disorders," said Kiran Nistala, MBBS, PhD, Chief Medical Officer of Zura. "With two readouts ahead and a third indication entering the clinic later this year, the Zura team is executing against the potential for tibulizumab to address the needs of patients across a range of immune-mediated diseases."