Zealand Pharma - Transactions related to share buy-back program (week 36, 2026)

About this update from Zealand Pharma A/s

Company announcement No. 46 / 2026 Zealand Pharma - Transactions related to share buy-back program (week 36, 2026) Copenhagen, Denmark, September 7, 2026 – Zealand Pharma A/S ("the Company" or “Zealand Pharma”) (Nasdaq: ZEAL) (CVR-no. 20045078), a biotechnology company transforming the future of metabolic health, today reports transactions related to its share buy-back program (the “Program”) for week 36 (August 31 - September 4, 2026). The Program is carried out in accordance with Article 5 of Regulation (EU) No 596/2014 (the Market Abuse Regulation, “MAR”) and Commission Delegated Regulation (EU) 2016/1052 (the “Safe Harbour Regulation”). Reference is made to company announcement no. 15 / 2026 dated May 7, 2026, which sets out the full terms of the Program. Under the Program, Zealand Pharma may repurchase shares for a total consideration of up to DKK 1.3 billion. The maximum number of shares that may be acquired under the Program is 7,152,557, and the Program commenced on May 7, 2026, and will be completed no later than October 31, 2026. The Company has appointed Danske Bank as lead manager for the Program. Danske Bank will make its own trading decisions independently of, and without influence from, the Company. Transactions executed in week 36 The following transactions have been executed on Nasdaq Copenhagen (XCSE) under the Program during week 36 (August 31, 2026 - September 4, 2026): Date Number of shares Average purchase price (DKK) Transaction value (DKK) Accumulated as per latest announcement 2,863,000   868,603,680 31/08/2026  60,000  300.77  18,046,200 01/09/2026  40,000  303.71  12,148,400 02/09/2026  35,000  308.91  10,811,850 03/09/2026  23,000  310.38  7,138,740 04/09/2026  25,000  309.31  7,732,750 Accumulated (W36) 183,000   55,877,940 Total accumulated under the Program 3,046,000   924,481,620 Treasury shares and share capital Following the transactions described above, Zealand Pharma holds a total of 3,916,842 treasury shares, corresponding to approximately 5.47% of the Company’s share capital. The total number of shares in Zealand Pharma is 71,578,758, each with a nominal value of DKK 1. Additional information Detailed information on each transaction executed under the Program is available in the appendix to this company announcement. About Zealand Pharma Zealand Pharma A/S (Nasdaq: ZEAL) is a biotechnology company focused on advancing medicines for obesity and metabolic health. Combining more than 25 years of peptide R&D expertise with a proprietary data platform that leverages advanced data driven and AI/ML approaches, Zealand Pharma aims to lead a new era in obesity and metabolic health. To date, more than 10 Zealand Pharma invented drug candidates have entered clinical development, of which two products have reached the market and three candidates are in late-stage development. The Company has collaborations with global pharmaceutical and biotechnology partners for research, development, and commercialization. Founded in 1998, Zealand Pharma is headquartered in Copenhagen, Denmark, with a U.S. presence in Boston, Massachusetts. Learn more at www.zealandpharma.com. Contacts Eric Rojas (Investors) Vice President, Head of Investor Relations Zealand Pharma Email: [email protected] Neshat Anis Ahmadi (Investors) Investor Relations Manager Zealand Pharma Email: [email protected] Rachel James-Owens (Media) Vice President, Corporate Communications and Media Relations Zealand Pharma Email: [email protected] Andreas Hylleberg Mølleskov (Media)  Director, External Communications Zealand Pharma Email: [email protected] Attachment Zealand Pharma - Share buy back - Transactions in week 36

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