Smith & Nephew PlcLSE: SN.

Investor Presentation November 2025 - February 2026

· Issued by Smith & Nephew Plc
Investor Presentation November 2025 - February 2026


1856

Smith+Nephew established

1856-1896

Thomas James Smith opened a chemist shop in Hull,

UK and develops a new method for refining cod liver oil.

In 1896 Horatio Smith entered a partnership with his uncle forming TJ Smith & Nephew

1914

Days after the outbreak of WW1, we received an order to provide surgical and field dressing supplies to French

army within 5 months

From 50

To 1200 1928

We produced an

1995

Acquired

Acufex Microsurgical Inc, making us a market leader in arthroscopic surgical devices

1995

We were listed on the New York Stock Exchange and in 2001 became a constituent member

1986

Key acquisitions of Richards Medical in Memphis, specialists in orthopaedic products and DYONICS, an

arthroscopy specialists based in Andover

2001

Introduced OXINIUM◊, a new material that improves performance and increases the service life of total

During WW1, staff grew from 50 to 1,200

1937

We developed a special low-temperature plaster

for the Everest climbers on the 1953 expedition.

It enabled them to send back camera films, sealed

and airtight!.

experimental bandage ElastoplastTM

1937

We were listed on the London stock exchange

of the UK FTSE-100 index

joint replacement systems 2011

PICO◊, the first pocket-sized, single-use system, revolutionizes the negative pressure wound therapy market

2013

JOURNEY◊ II BCS sets a new standard in knee implant performance, designed to empower patients

2020

Acquired

2019

Expanding in technologies of the future, we acquired:

  • Osiris Therapeutics

  • Ceterix Orthopaedics

  • Leaf Patient Monitoring System

  • Brainlab Orthopaedic Joint Reconstruction Business

    2020

    2017

    Acquired tissue regeneration developer Rotation Medical

    2021

    2015

    Acquired Blue Belt Technologies securing a leading position in orthopaedic robotics-assisted surgery

    2014

    Acquired Arthrocare Corp. to expand our sports medicine portfolio

    ~17,500

    employees over 100 Countries

    Today

    Tusker Medical Inc.

    to expand even more our ENT medicine portfolio

    Launched

    Real Intelligence and CORI◊ Surgical System; next generation handheld robotics platform

    Launched SMART TSF Circular Fixator; WEREWOLF ◊ FASTSEAL

    • 6.0 and LEGION CONCELOC;

FAST-FIX FLEX Meniscal Repair System; INTELLIO Connected Tower

3

2024

Acquired CartiHeal developer of novel technology

for cartilage regeneration

We exist to restore people's bodies and their self-belief by using technologies to take the limits off living. We call this purpose

"Life Unlimited"



100

100

Smith+Nephew is a portfolio medical

Smith+teNchenpohloegwy ibsuasiness portfolitohamt ehdaiscableen trading technoflogr yovbeursi1n6e0ssyears, that haasnbdeoepnetrraatdeisngin more for ovetrh1a6n01y0e0acros,untries and operates in more

than 100 countries

FTSE 100

AA ccoonnssttiittuueenntt ooff tthhee UUKK''ss FFTTSSEE 110000,, wwiitthh AADDRRss ttrraaddeedd oonn tthhee NNeeww YYoorrkk SSttoocckk EExxcchhaannggee

$5.28bn

Annual sales in 2022 wAnerneua$l5s.2alebsillinon2024 were $5.8 billion

ShaSrheasres

S+N hSa+sNa hparosgarepsrsoigvreessive dividednidvipdoelnicdy,poalnicdy,hasnd has paid apdaiivdidaednidviedveenrdy every year syinecaer s1i9n3c7e 1937

~19~,1070,0500

We have around 19,000 emploWyeeehsagvleobaarlolyund 17,500

employees globally

4



Our performance

Revenue

$5,810m +5.3%*

Trading profit

$1,049m 18.1% margin

Trading cash conversion

95%

5212 5215 5549 5810

4560

683

936 901 970 1049

101%

88%

49%

65%

95%

2020 2021 2022 2023 2024

2020 2021 2022 2023 2024

2020 2021 2022 2023 2024

Adjusted earnings per share (EPSA)

84.3¢

80.9 81.8 82.8 84.3

64.6

2020 2021 2022 2023 2024

Dividend per share

37.5¢**

37.5 37.5 37.5 37.5 37.5

2020 2021 2022 2023 2024

Net debt

$2,709m***

2535 2776 2709

1926 2049

2020 2021 2022 2023 2024

* Underlying growth percentage after adjusting for the effect of currency translation, acquisitions and disposals.

** Proposed dividend of 37.5¢ 5

*** Net debt includes lease liabilities.



A portfolio medical technology business

ALLEVYN◊ LIFE

Advanced Foam Wound Dressings

Advanced Wound Care

Advanced Wound Devices

PICO◊



Negative Pressure Wound Therapy

Collagenase SANTYL◊ Ointment Enzymatic debrider

COBLATION◊

Wand

REGENETEN◊

Bioinductive Implant

Advanced Wound Bioactives

ENT

Arthroscopic Enabling Technologies

Sports Medicine Joint Repair

$5.8bn Revenues

(2024)

Other Recon

CORI◊

Surgical System

Knees

Hips

Trauma & Extremities

JOURNEY◊ II BCS

Bi-Cruciate Stabilised Knee System

OR3O◊

Dual Mobility

EVOS◊

Plating System

6

Leading positions in attractive markets

Sports Medicine

Orthopaedics

Advanced Wound Management

Hip and Knee Implants Trauma and Extremities

$6.1bn

+5%

2024 market growth rate

+7%

2023 market growth rate

$16.8bn

+5%

2024 market growth rate

+8%

2023 market growth rate

$14.6bn

+7%

2024 market growth rate

+7%

2023 market growth rate

$12.5bn

+6%

2024 market growth rate

+5%

2023 market growth rate

DePuy Mitek 9%

Stryker

13%

Others

16%

Smith+Nephew

28%

DePuy Synthes 19%

Others

15%

Smith+Nephew

10%

Zimmer Biomet 31%

Others

37%

Smith+Nephew

4%

DePuy Synthes 24%

Others

55%

Smith+Nephew

14%

Solventum

15%

Mölnlycke

Arthrex

34%

Stryker

25%

Zimmer Biomet 11%

Stryker

24%

ConvaTec

6%

10%

~4% Weighted Average Market Growth Rate

based on pre-COVID 2017-19 growth



All market sizes and shares are 2024 estimates. These are generated by Smith+Nephew, based on publicly available sources

and internal analysis, and represent an indication of market shares and sizes. 7

Solid long-term demand drivers intact


Prevalence Growth in lifestyle related health conditions

Lifestyle Higher levels of physical activity later in life

Demographics More patients from

better life expectancy

Emerging markets Economic development driving healthcare access

Decentralised care

Shift to outpatient settings accelerated by COVID

8

The right to win across all business units

Orthopaedics

Sports Medicine & ENT

Advanced Wound Mgmt.

Full range across hips and knees

Differentiated implant technology, e.g. JOURNEY◊ II, OXINIUM◊, OR3O◊, EVOS◊

Robotic enabling technology, CORI◊ continuing to extend its functionality

Complete offering of Joint Repair, Tower, customer service

Leadership positions across key Sports Medicine segments

Scaleable synergies with other areas, through CORI and ASCs

Broadest portfolio of solutions covering all key wound types

Leading NPWT platform with market expansion potential

Strong evidence base, distinguishing from value segment

9



Delivering consistently higher revenue growth

Sustained acceleration

  • Shift to consistently higher growth maintained YTD 2025

  • 5% growth delivered YTD despite two fewer trading days

Better commercial execution

  • Improvement in US Recon performance continues

  • US Hips acceleration a further example of innovation-driven growth



Underlying revenue growth 2016-YTD 2025

Consistently higher growth

Historic growth

COVID disruption

3%

2% 2%

4.4%

10.3%

4.7%

7.2%

5.3% 5.0%

Average 2016-2019



-12.1%

2016 2017 2018 2019 2020 2021 2022 2023 2024 YTD 2025

10

Attention: This is an excerpt of the original content. To continue reading it, access the original document here.