Healthcare
Skyhawk Therapeutics Releases Twelve-Month cUHDRS Subcomponent Results from its Phase 1/2 Clinical Trial of SKY-0515 in Huntington's Disease
Skyhawk Therapeutics, Inc., a clinical-stage biotechnology company developing novel small molecule therapies designed to modulate RNA targets, announces cUHDRS subcomponent data from the twelve-month interim analysis of data from its Phase 1/2 clinical trial evaluating SKY-0515, an oral investigational treatment for Huntington's disease (HD).
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Twelve-month findings showed favorable and consistent trends for participants receiving SKY-0515 across all four cUHDRS subcomponents, including Total Functional Capacity (TFC), Total Motor Score (TMS), Symbol Digit Modalities Test (SDMT), and Stroop Word Reading Test (SWRT) Skyhawk also releases Clinician and Patient Global Impression (CGI and PGI) improvement of disease survey data, which shows that at twelve months no clinician or patient assessed disease progression – all saw either disease stabilization, or improvement BOSTON, June 30, 2026 /PRNewswire/ -- Skyhawk Therapeutics, Inc., a clinical-stage biotechnology company developing novel small molecule therapies designed to modulate RNA targets, announces cUHDRS subcomponent data from the twelve-month interim analysis of data from its Phase 1/2 clinical trial evaluating SKY-0515, an oral investigational treatment for Huntington's disease (HD). The twelve-month data, shared at the European Academy of Neurology, shows favorable and consistent trends for participants on SKY-0515 across all cUHDRS subcomponents, including Total Functional Capacity (TFC), Total Motor Score (TMS), Symbol Digit Modalities Test (SDMT), and Stroop Word Reading Test (SWRT). At twelve months, participants receiving SKY-0515 demonstrated favorable mean change from baseline TFC score of +0.07, compared with an expected worsening of -0.87 points from propensity score-weighted analyses which use Enroll-HD natural history datasets. At twelve months, participants receiving SKY-0515 demonstrated favorable mean change from baseline TMS score of -2.00, compared with an expected worsening of 2.21 points from propensity score-weighted analyses which use Enroll-HD natural history datasets. At twelve months, participants receiving SKY-0515 demonstrated favorable stabilization of mean change from baseline SDMT score of -0.19, compared with an expected worsening of -1.78 points from propensity score-weighted analyses which use Enroll-HD natural history datasets. At twelve months, participants receiving SKY-0515 demonstrated favorable mean change from baseline SWRT score of +3.44, compared with an expected worsening of -3.13 points from propensity score-weighted analyses which use Enroll-HD natural history datasets. Skyhawk also released today Clinician and Patient Global Impression (CGI and PGI) improvement of disease sur...