Shiseido : Research as a result of 30 years of collaboration between Shiseido and CBRC reveals a novel mechanism by which skin’s immune cells eliminate senescent cells

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Shiseido has collaborated with the Cutaneous Biology Research Center (CBRC)*1 at Massachusetts General Hospital to support research conducted at CBRC, which discovered as a new function of skin's immune cells the elimination of aged fibroblasts (senescent cells) and its mechanism. Advancing age alone does not correlate with the accumulation of senescent cells in the human skin. Among the potential mechanisms, Cytotoxic CD4+ T cell (CD4 CTL) *2, a type of immune cells, are strongly associated with the inhibition of accumulation of senescent cells. In addition, as a mechanism by which CD4 CTL suppress the accumulation of senescent cells, it was discovered, for the first time in the world, that CD4 CTL recognize a part of human cytomegalovirus (HCMV)*3 as an antigen presented on the surface of senescent cells, which then leads to the selective elimination of senescent cells (Figure 1). Shiseido, in collaboration with CBRC, has been engaged in research related to skin's immune function based on the idea of "preventing future skin problems with the power of the skin itself" for more than 30 years, making progress every step of the way on a continuous basis. Moving forward, the company aims to develop innovative values, such as that provided in this work relating to the suppression of accumulation of senescent cells through skin's innate immune system. The results of the present study have been published in the journal Cell *4 issued on March 30, 2023. *1 Cutaneous Biology Research Center (CBRC): A comprehensive center for advanced research and development in dermatology. Established in 1989 by Harvard Medical University and Massachusetts General Hospital with the support of Shiseido. Shiseido dispatches personnel to conduct joint research with world-class researchers. *2 Cytotoxic CD4+ T cell (CD4 CTL）: A type of T cell, it is also known to be an immune cell that is abundant in very long-lived people, who are considered models of ideal health and longevity. *3 Most humans are infected with this virus in childhood, which causes latent infections throughout their lives but are mostly asymptomatic. *4 One of the top academic journals in the world in the field of life science

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