Pre Close Statement

Synexus Clinical Research PLC 28 September 2007 Synexus Clinical Research plc ("the Company") Pre Close Statement Synexus Clinical Research plc, which provides clinical trials services for the global pharmaceutical industry, confirms it will release its interim results for the six months ended 30 September 2007 in the week commencing 3 December 2007. Prior to entering its close period, the Company today issues a trading update. As expected, given previously announced delays to major contracts, trading in the first half has been challenging. However, significant new contract wins since 31 March 2007 mean that the Company's forward order book is presently at a record level of £18.5m with a further £19.0m of outstanding bid proposals. The Directors remain confident about the prospects for the Company for the remainder of the financial year. Press enquiries Synexus Clinical Research plc Tel: +44 (0)1257 230723 Michael Fort, Chief Executive Paul McCluskey, Chief Financial Officer Biddicks - Financial Public Relations Tel: +44 (0)20 7448 1000 Zoe Biddick Brewin Dolphin - NOMAD Tel: 0845 213 8600 Mark Brady/Alison Barrow This information is provided by RNS The company news service from the London Stock Exchange