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Physiomics Awarded New Contract by Numab
Physiomics plc has secured a new contract with Numab Therapeutics AG to develop a pharmacokinetic-pharmacodynamic (PK/PD) model for a key asset in Numab's Immunology and Inflammation pipeline. This collaboration aims to accelerate therapeutic development by informing the Target Candidate Profile and supporting early-stage, data-driven decision-making, with completion anticipated in the second quarter of 2026. Disclaimer*

About this update from Physiomics Plc
28 January 2026 Physiomics plc ("Physiomics" or the "Company") Physiomics Awarded New Contract by Numab Therapeutics Physiomics plc (AIM: PYC), a leading mathematical modelling, data science and biostatistics company supporting the development of new therapeutics and personalised medicine solutions, is pleased to announce a new contract with its valued and long-standing client, Numab Therapeutics AG ("Numab Therapeutics"). This project reflects the continued application of Physiomics' modelling expertise across Numab Therapeutics' pipeline to accelerate the development of innovative therapies, building further on the already well-established relationship. Numab Therapeutics is a biopharmaceutical company focused on the discovery and development of next-generation multispecific antibody-based therapeutics for inflammation and oncology. Under this new contract, Physiomics will develop a pharmacokinetic-pharmacodynamic (PK/PD) model to inform the Target Candidate Profile of a key asset in Numab Therapeutics' Immunology and Inflammation pipeline. The modelling work is intended to support data-driven decision-making at an early stage of development and is expected to commence imminently, with completion anticipated within Q2 2026. Dr Peter Sargent, CEO of Physiomics, commented: " We are delighted to continue our collaboration with Numab Therapeutics and to have the opportunity to contribute further insights across its promising pipeline. In particular, this work allows us to support earlier research and development decisions through quantitative, data-driven approaches, helping to shape candidate profiles at a critical stage and thus streamlining drug development journeys." For more information about Physiomics and its services, please visit www.physiomics.co.uk . Enquiries: Physiomics plc Dr Peter Sargent, CEO +44 (0)1235 841575 Hybridan LLP (Broker) Claire Louise Noyce +44 (0) 203 764 2341 Strand Hanson Ltd (NOMAD) James Dance & James Bellman +44 (0)20 7409 3494 Notes to Editor About Physiomics Physiomics plc combines expertise across Modelling & Simulation, Biostatistics, Data Science and Bioinformatics, together with deep biology expertise, to help biotech and pharma companies streamline their drug development journeys. Our approach is to help derive insight from all relevant and often disparate data in order to de-risk decision making and optimise research design across discovery, pre-clinical and clinical studies. Through use of cutting-edge computational tools, bespoke models and our proprietary Virtual Tumour technology, the Physiomics team has informed the development of over 140 commercial projects, with over 125 targets and drugs modelled. Clients include Merck KGaA, Astellas, Bicycle Therapeutics, Numab Therapeutics & CRUK.