Business
Orexo : Q1 2026 Interim Report 2026
Orexo : Q1 2026 Interim Report
About this update from Orexo Ab
Q1 2026 Interim Report April 28, 2026 Well positioned to advance pipeline to value inflection points "We have taken an important step forward to ensure the company has the capacity to develop our pipeline and products where we see significant longterm potential. I am certain the greatest value opportunities are in projects where Orexo maintain a central role from development to commercialization." Nikolaj Sørensen, President and CEO OX640, nasal powder-based rescue medication for anaphylaxis Content Financial summary January - March Total net revenues of SEK 5.0 m (13.2) Net earnings for the period is SEK -105.2 m (-90.6) Cash flow for the period is SEK -527.9 m (-66.7) Earnings per share before and after dilution SEK -3.00 (-2.63) Net earnings for the period for discontinued operations is SEK -28.7 m (74.7). Operational highlights January - March Izipry™ continued to progress stability and reliability studies. NDA resubmission to the FDA is planned for Q3 2026. Commercialization is intended through a partnering strategy. OX640 accelerated its commercial-scale manufacturing readiness ahead of entering pivotal clinical studies in Q4 2026 First in-vivo study conducted for OX390, with data read-out in Q2 2026 The AmorphOX ® exploratory nasal semaglutide program, OX472, expanded into oral delivery, with formulation development initiated for semaglutide tablets Patent application filed covering oral semaglutide tablets Hosted R&D Day in Stockholm, Sweden, targeting investors, analysts and media. Significant events January - March Early redemption of the senior secured social bond 2024/2028 was exercised, covering a total outstanding nominal amount of SEK 500 m. Significant events after the end of the period No significant events after the end of the period. Quarter in brief 2 About Orexo 3 CEO comments 4 Technology 6 Pipeline & partnership 8 Operational development 9 Financial development 10 Other information 12 Financial reports, notes and key figures 13 SEK m unless otherwise stated 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Net revenues 5.0 13.2 26.0 Cost of goods sold -0.5 -4.7 -14.5 Operating expenses -79.5 -84.7 -364.3 Of which research and development expenses/operating expenses, % 54 56 64 EBIT -75.0 -76.3 -352.7 EBIT margin % neg. neg. neg. EBITDA -66.1 -65.2 -285.7 Earnings per share. before dilution, SEK -3.00 -2.63 -11.65 Earnings per share. after dilution, SEK -3.00 -2.63 -11.65 Cash flow from operating activities -33.3 -41.6 -195.4 Cash and cash equivalents Orexo 333.8 119.1 912.4 Cash and cash equivalents payable to Dexcel 52.3 - - Total Cash and cash equivalents 386.2 119.1 912.4 Unless otherwise stated, all data refers to continued operations post Zubsolv US divestment as of Dec. 31 2025. Discontinued operations is presented in Note 10. Note: Izipry™, nasal rescue medication for opioid overdose, incl. high dose of naloxone; OX640, nasal rescue medication for severe allergic reactions, incl. anaphylaxis; OX390, nasal rescue medication for adulterated overdose. Contact persons Nikolaj Sørensen, President and CEO Fredrik Järrsten, EVP and CFO Lena Wange, IR & Communications Director +46 18 780 88 00 [email protected] Presentation April 28, at 2 pm CEST analysts, investors and media are invited to attend a presentation, incl. a Q&A. Participants may access the event via live webcast or teleconference through the following link: https://investorcaller.com/events/orexo/orexo-q1-report-2026 Prior to the call, presentation material will be available on the website under Investors/Rapport archive. Financial calendar May 7, 2026, 4 pm Annual General Meeting July 16, 2026, 7 am Interim Report Q2 2026 October 22, 2026, 7 am Interim Report Q3 2026 February 4, 2027, 7 am Interim Report Q4 2026, incl. Full Year Report Go to full IR calendar: https://orexo.com/ investors/calendar/ Stay updated www. orexo.com You can follow us on: LinkedIn, X and YouTube. Heritage 4 Drugs developed from idea to market¹ >25 Markets where these drugs have been approved Innovation >8 >500 AmorphOX-based next-generation drug formulations under research delivery technology AmorphOX 5 with AmorphOX >100 AmorphOX patents and patent applications technology 1. Of these four drugs, three are based on Orexo's first-generation drug delivery technology - the sublingual. Rooted in science, proven in market Orexo is a Swedish pharmaceutical company dedicated to advance treatments for severe diseases and life-saving rescue medications to meet future healthcare needs. AmorphOX ® is at the heart of Orexo's innovation - a proprietary powder-based drug delivery technology that enhances bioavailability and stability for both small and large molecules. This groundbreaking technology enables new possibilities in route of administration, manufacturing, and distribution of drugs. The expanding pipeline, powered by the AmorphOX platform, spans multiple therapeutic areas and delivery routes, accelerating the development of cutting-edge pharmaceuticals. This information is information that Orexo AB (publ.) is obliged to make public pursuant to the EU Market Abuse Regulation and the Swedish Securities Markets Act. The information was submitted for publication through the agency of the contact persons set out above at 7 am CEST on April 28, 2026. Well positioned to advance pipeline to value inflection points Successful transition after Zubsolv divestment The transaction closed on New Year´s Eve and most of the transition activities were completed during the first quarter. From a people perspective this includes re-organization in the US, provisions and payment of severance packages, and accelerated vesting of long-term incentive CEO comments in brief With the divestment of Zubsolv ® US, Orexo has entered a new phase. A stronger financial position allows us to step up investments in R&D, with our AmorphOX ® technology at the core. During the quarter, we made good progress, particularly in the OX640 program, where we are preparing to initiate our first pivotal clinical studies later this year. It is also encouraging to see how our R&D teams are continuing to use AmorphOX to improve stability and bioavailability in challenging molecules such as peptides. Finally, I am pleased with how the organization has handled the transition following the Zubsolv US divestment, including the care and respect shown to colleagues who needed to leave the US organization. programs for employees leaving the company. In addition, the divestment of Zubsolv US resulted in several changes to the balance sheet, with a significant impact on cash flow during the quarter. The most notable item was the redemption of the SEK 500 million corporate bond at the end of March. Payments of rebates and returns related to products sold by Orexo during 2025 also had a relatively significant impact on cash flow during the quarter. For the coming quarters, the cash impact from rebate and return payments is expected to be significantly lower. At the end of the quarter, cash amounted to SEK 386 million (of which SEK 52 million is attributable to Dexcel). This cash position places Orexo in a good position to finance the promising pipeline and advance our three focus areas; our development programs, exploratory research and partnered development, to the next value inflection. The divestment of Zubsolv US resulted in several changes to the balance sheet, with a significant impact on cash flow during the quarter. The most notable item was the redemption of the SEK 500 million corporate bond at the end of March. Orexo development projects making steady progress With our lead product OX640, an intranasal rescue medication for anaphylaxis, we are well positioned to take a leading role in a market that is on the verge of transforming from injectable to needle-free treatments. We are now entering the most intense and resource-intensive phase where we need to establish the commercial manufacturing line and initiate pivotal clinical studies. The first, a nasal allergy challenge study, is planned for Q4 this year and will be key to establishing the bioavailability of the commercial product. OX640 will be the company's main investment over the next two years, with total external expenses estimated to exceed SEK 200 million. Our OX390 project, a nasal rescue medication for adulterated overdoses, is being developed in partnership with the US authority, BARDA. The project advances according to the agreed timeline. It addresses a growing public health challenge related to overdoses involving adulterated opioids, where existing rescue treatments are often insufficient. Current activities include the first in-vivo study of the nasal formulations and preparation for a type C meeting with the FDA with a focus on the non-clinical plan. The results from the final stability and reliability studies required by the FDA for Izipry™ are looking promising and we are planning for a resubmission in the third quarter, with potential approval in early 2027. Following the sale of Zubsolv US, the strategy is to find a commercialization partner for Izipry in the US. The market is very competitive with decreasing prices of the low-dose naloxone nasal rescue medication. This is expected to position Izipry in a niche segment, where its higher dose, strong bioavailability, and thermostable formulation offer clear advantages, particularly in regions with cold climates and a high prevalence of fentanyl related overdoses. Exploring new applications of AmorphOX During the quarter, we have continued to explore potential for AmorphOX ® in peptides initially with a focus on GLP-1 agonists. The first study with nasal delivery was promising, but we need to continue optimization of the formulation to reach the desired bioavailability, especially for treatment of obesity where higher dosages are required. In parallel, we expanded our exploratory work to oral formulations, where applying the AmorphOX technology to combine peptides with supporting excipients in a single particle could improve their profile compared with oral products currently available on the market. We have during the quarter continued to explore potential for AmorphOX in peptides initially with a focus on GLP-1 agonists Early steps in partnering the technology The AmorphOX technology has applications beyond what is feasible for Orexo to pursue and explore. There are many opportunities to be found in products under development where companies are struggling with stability of their product and/or the bioavailability. Orexo is working with some smaller and larger companies to test the feasibility of AmorphOX in their products and our ambition is to grow this portfolio of projects moving beyond the current state, for example feasibility projects. New path, new opportunities and a lot of potential Potential value drivers near-term We have taken an important step forward to ensure the company has the capacity to develop our pipeline and products where we see significant long-term potential. 2026 Launched products Zubsolv ® EU Izipry TM Q3 FDA resubmission OX640 Q4 pivotal trial start OX390 Q2 in-vivo study results Explore GLP-1 agonist / vaccines Additional in-vivo studies 2027 Launched products Zubsolv US earn-out Izipry TM Q1 potential FDA approval Partnering OX640 H1 trial results Start final pivotal trials OX390 BARDA financing stage 2 Explore GLP-1 agonists / vaccines First human studies (if in-vivo are successful) Partnering is a continuous process for all projects without specific target dates I am certain the greatest value opportunities are in projects where Orexo maintain a central role from development to commercialization. This is also reflected in the capital allocation where our own projects take more than 80 percent of the investment in R&D. With the sale of Zubsolv we are well positioned to take our projects to important value inflections, which will be critical enablers to enter partnerships and if the opportunity is right also for Orexo to take an active role in the commercialization phase. Reaching the value inflection of our development programs is important to our ambitions for business development, to secure the financial capacity to advance our R&D focus areas and create shareholder value. Reaching the value inflection of our development programs is important to our ambitions for business development, to secure the financial capacity to advance our R&D focus areas and create shareholder value I want to show my appreciation to our employees in the US and Sweden who have been extraordinarily engaged and committed to Orexo during this transition following the sale of Zubsolv. Uppsala, Sweden, April 28, 2026 Nikolaj Sørensen President and CEO TECHNOLOGY Technology - AmorphOX AmorphOX key attributes Versatile applications Adaptable across multiple therapeutic areas and formulations. Ultra-fast absorption Designed for rapid onset, improving treatment efficiency. Superior bioavailability Maximizes active ingredient performance for optimal outcomes. Stabilizes peptides and biologics Protects sensitive molecules, ensuring integrity and efficacy. Needle-free delivery Enhances patient comfort and compliance with non-invasive options. Preservative-free formulation Clean, safe, and aligned with modern health standards. Reduces complexity and risk of microbial contamination compared to liquid sprays. AmorphOX ® is a powder-based drug delivery technology that stabilizes amorphous materials - such as peptides and biologics - and is designed to support high bioavailability, enabling next-generation drug development. Drug Carrier materials Clinically validated, stable technology Optionally, other excipients such as permeability enhancer Examples: Chemical degradation after accelerated stability studies at 40°C/75% RH Small molecules Epinephrine 0.3% after 24 months Peptides Semaglutide 0.1% after 6 months Biologics Protein (spike protein). Retained activity after 3 months (40°C) AmorphOX has been validated in multiple clinical studies across nasal rescue medications, including naloxone (Izipry™), nalmefene (OX125), and epinephrine (OX640). The technology forms an amorphous composite that delivers rapid absorption, high bioavailability, and strong physical and chemical stability across temperature ranges, while maintaining rapid dissolution. A versatile, modality agnostic drug delivery platform AmorphOX supports small molecules, peptides, proteins, and vaccines across multiple routes of administration, including nasal, oral, sublingual, and parenteral, and can be formulated as powders, tablets, capsules, or powders for reconstitution. Plasma concentration Superior pharmacokinetic (PK) properties with more rapid onset, higher peak and overall exposure AmorphOX ® Traditional liquid Time (minutes) TECHNOLOGY Enabling tailored formulation and product development with AmorphOX Leveraging the AmorphOX ® design space to tailor formulations for each API Medical API need/TPP Formulation candidate Final formulation Final commercial product Analysis of critical parameters In-vivo studies Process optimization Note: TPP. Target Product Profile. API, Active Pharmaceutical Ingredient Competitive advantage through a proven, scalable manufacturing platform Image 1 Image 2 Image 3 Images: Spray dryer and filling equipment used in Orexo's FDA-inspected production sites. Image 1, An active substance solution that is subsequently spray dried into powder. Image 2, Operator control for spray drying process. Image 3, Spray dried AmorphOX powder. Development program Technology Partnership Preclinical Clinical Registration Approved Exploratory/ Large molecules OX472 GLP-1 agonist, semaglutide Vaccine , influenza Own projects/ Small molecules OX640 , epinephrine, incl. anaphylaxis OX390 , atipamezole, overdose caused by adulterated drugs Izipry™ , naloxone, overdose caused by opioids Launched products Approved products developed by Orexo Zubsolv ® US, opioid dependence Sublingual platform US Zubsolv EU, opioid dependence Sublingual platform EU Abstral ® , breakthrough cancer pain Sublingual platform EU, US, RoW Edluar ® , insomnia Sublingual platform EU, US, RoW Pipeline & partnership PIPELINE & PARTNERSHIP Mark Smith, Professor of Psychology and Neuroscience at Davidson College and a leading expert in addiction research, participated in Orexo's R&D Day on March 24 through a brief pre-recorded interview. The topic was "Why countermeasures are needed for the emerging threats from xylazine, medetomidine, and fentanyl combinations." The full interview can be accessed here: https://www.youtube.com/ watch?v=d30jlNPp12c. Projects in brief OX472 OX472 is a project investigating applying the AmorphOX ® powder-based formulation technology to GLP-1 agonists. Initially the development has been focused on intranasal semaglutide and an in-vivo proof-of-concept study demonstrated promising pharmacokinetic data for intranasal AmorphOX formulations in comparison to oral semaglutide tablets (Rybelsus ® ).1 These results support the continued development of AmorphOX to enable needle-free intranasal delivery of large molecules, such as semaglutide and other peptides, offering improved convenience, potential adherence benefits, no refrigeration requirement, and the possibility of extended dosing intervals. The AmorphOX technology could also support other routes of administration, and these are explored in parallel with the intranasal administration. OX472 is protected by patents and patent applications ranging from 2041 to 2047. Vaccine An intranasal influenza vaccine, developed with Abera Bioscience, combines the AmorphOX powder-based formulation technology with Abera's BERA™ vaccine platform. In-vivo proof-of-concept data in rats demonstrated robust systemic and mucosal immune responses (IgG and IgA), comparable to a liquid nasal formulation. The results support the potential of AmorphOX for developing thermostable, needle-free mucosal vaccines. OX640 The aim with OX640 is to develop a powder-based intranasal epinephrine product for the emergency treatment of severe allergic reactions, including anaphylaxis. Epinephrine is commonly used for the emergency treatment of allergic reactions, including anaphylaxis. Epinephrine is a very unstable active ingredient sensitive to chemical degradation, particularly when exposed to elevated temperatures, which is the reason why the vast majority of today's commercial epinephrine products have limited shelf-life and restrictive storage conditions. OX640 is protected by patents and patent applications ranging from 2041 to 2044. OX390 Orexo is developing, OX390, in partnership with the Biomedical Advanced Research and Development Authority (BARDA). OX390 builds on the substance atipamezole, combined with a novel formulation and route of administration supported by the AmorphOX platform. It is intended to reverse respiratory depression from adulterated opioid overdoses, a growing issue in the US due to the spread of animal tranquilizers, namely xylazine and medetomidine. There are no known competitor products on the market. OX390 is protected by patents and patent applications ranging from 2041 to 2046. Izipry TM Opioid overdose is a life-threatening condition, characterized by loss of consciousness and respiratory depression. Based on the AmorphOX technology, Orexo has developed a high-dose naloxone rescue medication, Izipry, designed to reverse opioid overdoses, including those from highly potent synthetic opioids such as fentanyl and fentanyl analogues. Izipry is protected by patents until 2039. Rybelsus ® is a registered trademark of Novo Nordisk A/S. OPERATIONAL DEVELOPMENT 3 strategic focus areas to maximize value of the AmorphOX technology EXPLORE New applications of the AmorphOX ® technology are key to unlocking substantial future value creation and partnership generation For the GLP-1 semaglutide program with intranasal delivery the exploratory formulation work progressed, supporting continued evaluation of new formulation approaches. Exploration of new AmorphOX applications progressed into oral peptide Q1 2026 developments delivery, This included the initiation of formulation development for semaglutide tablets as part of the preparations for a preclinical in-vivo pharmacokinetic proof-of-concept study planned for H2 2026. One new patent application was filed covering an oral semaglutide tablet. Within the vaccine project, activities focused on expanding the evidence base, primarily through potential continued collaboration with Abera Bioscience and discussions with additional potential partners across both industry and academia. DEVELOP Proprietary projects drive greater value capture and renewed commercialization opportunities for Orexo, either standalone or together with a partner PARTNER Power partners' proprietary projects with the AmorphOX technology Q1 2026 developments product continued during the quarter. Data from these studies will be included in the updated new drug application (NDA) planned to be submitted to the FDA in the third quarter of 2026, in line with the most recently communicated timeline. The NDA follows the Complete Response Letter received from the agency in the third quarter of 2024. mercial scale. The particles demonstrated uniform quality and high performance, supporting the initiation of commercial manufacturing of the nasal powder. This represents a critical step ahead of the first pivotal clinical study, planned for the fourth quarter of 2026, in line with the previously communicated timeline. In parallel, Human Factors studies were initiated to evaluate the instructions for use of the product. lity and pharmacokinetics in four selected formulations. The study is expected to be completed in the second quarter of 2026. A team from Orexo visited BARDA in Washington, DC, for continued discussions related to the project. In parallel, the next steps in the preclinical program were prepared, with a focus on toxicology stu- dies, and an advisory meeting with the FDA is planned for the second quarter of 2026. Izipry™ - Studies to evaluate the stability and reliability of the final commercial OX640 - Analysis was conducted on the spray dried powder manufactured at com- OX390 - An in-vivo proof-of-concept study was initiated to evaluate bioavailabi- O1 2026 developments Feasibility studies with potential partners supported efforts to broaden the application and partnering scope of AmorphOX beyond Orexo's own capacity and molecule access. Financial development On December 31, 2025, Orexo closed the transaction with Dexcel Pharma USA acquiring the full rights to Zubsolv ® in the US. The upfront consideration paid at closing of the transaction amounted to USD 91 m plus the value of inventory of USD 3.8 m. Furthermore, Orexo is entitled to a contingent consideration of up to USD 16.8 m, based on future net sales during 2026 and 2027. Following the transaction, segment reporting has ceased and operations are no longer monitored on a segment basis. The Q1 financial reporting therefore reflects continued operations previously reported within the US Commercial and HQ & Pipeline segments, while the Zubsolv US business is presented as discontinued operations in Note 10. Net revenues Total net revenues for Q1 amounted to SEK 5.0 m (13.2). The decrease is mainly explained by lower Zubsolv ex-US revenues of SEK 0.5 m (8.1) reflecting the absence of tablet sales to Orexo's partner Accord Healthcare while finalizing their Zubsolv manufacturing setup. Lower Abstral royalties of SEK 0.7 m (1.7) also contributed to the decrease. Cost of goods sold Cost of goods sold (COGS) for Q1 amounted to SEK 0.5 m (4.7), the decrease is due to absence of Zubsolv ex-US tablet sales to Orexo's partner Accord Healthcare. Operating expenses Selling expenses amounted to SEK 0.1 m (-1.7) for Q1. The decrease is mainly explained by lower marketing related costs for Izipry™ and DMHP activities. Also positive adjustment for long-term incentive programs contributed to the decrease. Administrative expenses amounted to SEK -37.5 m (-30.4) for Q1. The increase is mainly explained by higher expenses for seeking a settlement in the DOJ investigation. Research and development costs amounted to SEK -50.1 m (-47.1) for Q1. The increase is mainly explained by higher costs for OX640 and OX390 partly offset by lower internal costs. Other operating income and expenses amounted to SEK 8.0 m (-5.6) for Q1. This is mainly explained by higher BARDA reimbursement of OX390 related costs of SEK 7.1 m (0.0), higher exchange rate gains SEK 0.4 m (-7.1) derived from revaluations of parent company balance sheet items in foreign currency, predominantly in USD partly offset by lower insurance reimbursement of SEK 0.3 m (1.1) of DOJ investigation related legal expenses. Operating profit EBITDA amounted to SEK -66.1 m (-65.2) for Q1 EBIT amounted to SEK -75.0 m (-76.3) for Q1. Net financial items and tax Net financial items for Q1 amounted to SEK -29.2 m (-14.1) and are mainly explained by higher bond loan costs of SEK -32.9 m (-11.5) following the early redemption of the corporate bond and by lower negative unrealized exchange rate impact of SEK -0.6 m (-2.6) derived from the parent company's foreign currency bank accounts in USD. This was partly offset by higher interest income from bank accounts of SEK 4.4 m (0.3). Total tax expenses amounted to SEK -1.0 m (-0.3) for Q1. Orexo performs regular assessments of its deferred tax asset and adjusts according to the recognition requirements of IAS 12. Net earnings Net earnings for Q1 amounted to SEK -105.2 m (-90.6). Cash and cash flow Cash flow from operating activities amounted to SEK -33.3 m (-41.6) for Q1 and was impacted primarily by negative operating earnings, costs for the early redemption of the corporate bond and a negative adjustment for non-cash items. This was partly offset by positive changes in working capital primarily driven by the collection of all Zubsolv sales related receivables from 2025. In addition, under the transition services agreement following the divestment of the US Zubsolv business to Dexcel, Orexo continues to collect Zubsolv revenues on behalf of Dexcel during the first nine months of the year with a positive impact on working capital. During the quarter, Orexo exercised its right to carry out an early redemption of the outstanding senior secured social bond which had a negative impact of SEK -490.0 m (0.0) on financing activities. Note: Unless otherwise stated, all numbers refer to the Group and relate to the current quarter, while numbers in parentheses refer to the corresponding period in the previous year. Total cash flow for the period amounted to SEK -527.9 m (-66.7) excluding a positive USD currency effect of SEK 9.2 m (-10.8). As of March 31, 2026, total cash and cash equivalents amounted to SEK 386.2 m (119.1) of which Orexo's own cash and cash equivalents amounted to SEK 333.8 m (119.1) and cash and cash equivalents payable to Dexcel amounted to SEK 52.3 m (0.0). Interest-bearing liabilities amounted to SEK 0.0 m (460.8), i.e. a positive net cash position of SEK 386.2 m (-341.7). Cash and cash equivalents decreased by SEK 526.2 m from Q4 2025. Investments Gross investments in tangible and intangible fixed assets amounted to SEK 0.1 m (0.0) for Q1. Equity Shareholders' equity on March 31, 2026, was SEK 364.7 m (-161.3). Discontinued operations Net earnings for Q1 amounted to SEK -28.7 m (74.7) and are explained mainly by post transaction related restructuring costs. Parent company Net revenues for Q1 amounted to SEK 5.0 m (13.2), the decrease is mainly explained by lower Zubsolv ex-US revenues of SEK 0.5 m (8.1) due to no sales of tablets to Orexo´s partner Accord Healthcare and lower Abstral royalties of SEK 0.7 m (1.7). EBIT amounted to SEK -106.8 m (51.8) for Q1. Earnings before tax amounted to SEK -115.4 m (-38.5) for Q1 mainly explained by higher operating expenses from research and development activities in Sweden and the US. Higher negative financial items had a negative impact mainly from the early redemption of the outstanding senior secured social bond. Investments in equipment for the development organization for Q1 amounted to SEK 0.1 m (0.0). As of March 31, 2026, cash and cash equivalents in the parent company amounted to SEK 41.6 m (24.3). Parent company shareholders' equity at March 31, 2026, was SEK 471.0 m (988.9). The decrease over the same period last year is mainly explained by negative operating earnings and SEK 269.2 m write-down for accounting purposes of group receivable. Other information The share and shareholder information Owners No. of Ordinary Shares C Shares Share of Capital (%) Novo Holdings A/S 9,643,184 25.95 Avanza Pension 2,872,244 7.73 Orexo AB 646 2,029,583 5.46 ATP, the Danish Labour Market Supplementary Pension 1,780,633 4.79 Anders Walldov, direct and indirect 1,500,000 4.04 Nordnet Pension Insurance 912,965 2.46 Swedbank Insurance 855,850 2.30 Bank of Montreal 779,914 2.10 Stefan Hansson 490,883 1.32 Jan Robert Pärsson 484,034 1.30 Totalt top 10 19,320,353 2,029,583 57.45 Others 15,806,703 42.55 Totalt 35,127,056 2,029,583 100.00 SHAREHOLDERS ANALYSTS Klas Palin, DNB Carnegie Dr. Samir Devani, RX Securities Annual General Meeting 2026 Shareholders are summoned to an annual general meeting, to be held on May 7, 2026, at 4 pm at Virdings Allé 28 in Uppsala, Sweden. Further information see https://orexo.com/who-we-are/governance/general-meetings/ Sustainability The divestment of Zubsolv ® US to Dexcel Pharma USA as of December 31, 2025, has a significant impact on Orexo's sustainability work, particularly within the focus areas of Governance, Access to Healthcare, and Environment and Climate Change. A review of the sustainability strategy will be conducted to assess the implications for the company's future sustainability priorities and operational activities. Risks and uncertainty factors Orexo works continuously and proactively to identify, assess, and mitigate both existing and emerging risks. Significant risks and uncertainties are described in Note 4, Dispute, in the Interim Report, as well as in the Annual Report for 2025. In light of increased uncertainty regarding tariffs and global trade conditions, Orexo's development projects may be affected, as they rely on an international supply chain. While the current level of uncertainty makes it difficult to implement immediate measures, the company is closely monitoring developments and actively managing risks under various scenarios. This work may result in adjustments to certain elements of the planned supply chain. Forward-looking statements This report contains forward-looking statements that reflect the company's current expectations. Although the company believes that the expectations reflected in such forward-looking statements are reasonable, no assurance can be given that such expectations prove to be correct as they are subject to risks and uncertainties that could cause actual results to differ materially due to a variety of factors. Forward-looking statements speak only as of the date they were made, and, other than as required by applicable law, the company undertakes no obligation to update any of them considering new information or future events. Auditing This report has not been reviewed by the company's auditors. Glossary SHARE¹ Listing Nasdaq Stockholm, mainlist Number of shares 37,156,639 Number of votes 35,330,014 Market capitalization SEK 812 million ISIN code SE0000736415 Ticker code ORX 1. The share can also be traded as an ADR on the OTCQX market in the United States. View https://orexo.com/glossary/ Financial reports, notes and key figures CONDENSED CONSOLIDATED STATEMENT OF OPERATIONS SEK m Notes 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Net revenues 9 5.0 13.2 26.0 Cost of goods sold -0.5 -4.7 -14.5 Gross profit 4.6 8.5 11.5 Selling expenses 0.1 -1.7 -14.6 Administrative expenses -37.5 -30.4 -110.7 Research and development expenses -50.1 -47.1 -233.1 Other operating income and expenses 8.0 -5.6 -6.0 Operating earnings (EBIT) -75.0 -76.3 -352.7 Net financial items -29.2 -14.1 -50.3 Earnings after financial items -104.2 -90.3 -403.0 Income tax 5 -1.0 -0.3 -0.3 Net earnings for the period for continued operations -105.2 -90.6 -403.3 Net earnings for the period for discontinued operations -28.7 74.7 1,042.6 Net earnings for the period -133.9 -15.9 639.3 Earnings per share continued operation before dilution, SEK -3.00 -2.63 -11.65 Earnings per share continued operation after dilution, SEK -3.00 -2.63 -11.65 CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME SEK m Notes 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Earnings for the period 133.9 -15.9 639.3 Other comprehensive income Items that may subsequently be reversed to the statement of operations : Translation differences 10 4.8 -19.1 - Other comprehensive earnings for the period. net after tax 4.8 -19.1 0.0 Total comprehensive earnings for the period 1 -129.1 -35.0 639.3 1 All equity and earnings for the respective period are attributable to the Parent Company's shareholders CONDENSED CONSOLIDATED BALANCE SHEET SEK m Notes 2026 Mar 31 2025 Mar 31 2025 Dec 31 ASSETS Fixed assets Tangible fixed assets 41.3 59.6 45.7 Intangible assets 0.4 25.5 0.4 Right-of-use assets 9.0 25.7 10.7 Deferred tax assets 5 22.6 41.8 21.9 Other financial assets 60.8 20.7 59.3 Total fixed assets 134.1 173.2 138.0 Current assets Inventories 0.0 36.2 0.0 Accounts receivable 16.6 161.8 184.7 Other receivables 60.3 15.7 52.7 Prepayment and accrued income 13.3 23.0 15.0 Cash and cash equivalents 386.2 119.1 912.4 Total current assets 476.3 355.8 1,164.8 TOTAL ASSETS 610.4 529.0 1,302.8 SHAREHOLDERS' EQUITY AND LIABILITIES Total shareholders' equity 364.7 -161.3 490.6 Long-term liabilities Provisions 7.6 19.8 13.7 Interest bearing liabilities 6 - 460.8 483.1 Lease liabilities, long-term 2.8 4.1 0.7 Total long-term liabilities 10.5 484.7 497.5 Current liabilities and provisions Accounts payable 57.9 39.9 92.6 Provisions 52.8 94.1 155.1 Other liabilities 67.7 11.4 7.9 Accrued expenses 52.6 41.2 51.4 Lease liabilities, current 4.2 19.0 7.7 Total current liabilities 235.2 205.6 314.7 Total liabilities 245.7 690.3 812.2 TOTAL SHAREHOLDERS' EQUITY AND LIABILITIES 610.4 529.0 1,302.8 CONDENSED CONSOLIDATED CHANGES IN SHAREHOLDERS' EQUITY SEK m 2026 Mar 31 2025 Mar 31 2025 Dec 31 Opening balance, shareholders' equity 490.6 -126.3 -126.3 Total comprehensive earnings for the period -129.1 -35.0 639.3 Share-based payments 2 3.2 - 22.7 Reclassification of translation differences from other comprehensive income - - -45.2 Closing balance, shareholders' equity 364.7 -161.3 490.6 2 The change compared with previous periods relates to the change in the option programs from cash-based to equity-based CONDENSED CONSOLIDATED CASH FLOW STATEMENTS SEK m Notes 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Operating earnings (EBIT) -75.0 -76.3 -352.7 Interest received 3.1 0.7 4.1 Interest paid -26.9 -11.5 -47.1 Income taxes paid - - - Adjustment for non-cash items 3 -96.0 5.9 143.8 Cash flow from operating activities before changes in working capital -194.9 -81.2 -251.9 Changes in working capital 161.5 39.5 56.5 Cash flow from operating activities -33.3 -41.6 -195.4 Acquisition of tangible and intangible fixed assets -0.1 - - Change in financial assets -0.1 -19.2 -19.2 Cash flow from investing activities -0.2 -19.2 -19.2 Amortization of lease liability -4.3 -5.9 -22.3 Redemption of bond -490.0 - - Change of repurchased part in bond - - 20.0 Cash from financing activities -494.3 -5.9 -2.3 Cash flow from continued operations for the period -527.9 -66.7 -216.9 Cash flow from discontinued operations for the period -7.5 73.4 1,023.5 Cash and cash equivalents at the beginning of the period 912.4 123.3 123.3 Exchange-rate differences in cash and cash equivalents 9.2 -10.8 -17.5 Changes in cash and cash equivalents -526.2 -4.2 789.1 Cash and cash equivalents at the end of the period 386.2 119.1 912.4 Key Figures3 Orexo makes use of the key figures (continued business) below and believe they are useful for readers of the financial reports as a complement to other performance measures when assessing implementation of strategic investments and the Group's ability to meet financial objectives and commitments. 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec EBIT margin, % neg. neg. neg. Return on shareholder equity, % neg. neg. 351.0 Net debt, SEK m -386.2 341.7 -429.2 Debt/equity ratio, % 0.0 neg. 98.5 Equity/assets ratio, % 59.7 neg. 37.7 Number of shares, before dilution 35,126,410 34,505,226 34,625,973 Number of shares, after dilution 39,593,836 34,505,226 39,553,329 Earnings per share continued operations, before dilution, SEK -3.00 -2.63 -11.65 Earnings per share continued operations, after dilution, SEK -3.00 -2.63 -11.65 Number of employees at the end of the period 65 110 72 Shareholders' equity, SEK m 364.7 -161.3 490.6 Capital employed, SEK m 364.7 299.5 973.7 Working capital, SEK m -145.1 31.1 -62.2 3 Definitions and reconcilliations of key figures are presented in the end of this report PARENT COMPANY STATEMENT OF COMPREHENSIVE INCOME SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Earnings for the period -115.4 -38.5 -467.2 Other comprehensive income - - - Total comprehensive earnings for the period -115.4 -38.5 -467.2 CONDENSED PARENT COMPANY STATEMENT OF OPERATIONS SEK m Notes 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Net revenues 5.0 13.2 26.0 Cost of goods sold -0.5 -18.1 -5.1 Gross profit 4.6 -4.9 20.9 Selling expenses - -3.6 -15.8 Administrative expenses -21.3 -15.2 -61.8 Research and development costs -94.8 -41.0 -202.4 Other operating income and expenses 7 4.7 12.8 7.3 Operating earnings (EBIT) -106.8 -51.8 -251.8 Interest income and expenses 14.2 16.8 61.5 Other financial income and expenses -22.8 -3.4 -277.0 Net financial items -8.5 13.4 -215.5 Earnings before tax -115.4 -38.5 -467.2 Income tax 5 - - - Earnings for the period -115.4 -38.5 -467.2 CONDENSED PARENT COMPANY BALANCE SHEET SEK m Notes 2026 Mar 31 2025 Mar 31 2025 Dec 31 ASSETS Fixed assets Patents, intellectual property rights, proprietary intangible assets and software 0.4 23.2 0.4 Equipment, machinery, renovation of the property of others 41.3 59.6 45.7 Shares and participations in group companies 296.5 290.3 295.3 Participations and securities in other companies 19.2 19.2 19.2 Total fixed assets 357.3 392.3 360.6 Current assets Inventories 0.0 2.4 0.0 Accounts receivable 7.7 7.4 3.7 Other receivables 11.1 7.8 8.2 Receivables from Group companies 7 92.1 1,058.4 709.2 Prepaid expenses and accrued income 14.9 15.0 18.3 Cash and cash equivalents 41.6 24.3 14.7 Total current assets 167.3 1,115.3 754.2 TOTAL ASSETS 524.6 1,507.5 1,114.8 SHAREHOLDERS' EQUITY, PROVISIONS AND LIABILITIES Total shareholders' equity 471.0 988.9 583.2 Long-term liabilities Other provisions 6.0 18.6 8.7 Interest bearing liabilities 6 - 460.8 483.1 Total long-term liabilities 6.0 479.4 491.8 Current liabilities Accounts payable 10.9 11.2 11.5 Other liabilities 13.8 9.6 7.0 Liabilities to Group companies - - - Accrued expenses and deferred income 22.9 18.5 21.4 Total current liabilities 47.6 39.2 39.9 Total liabilities 53.6 518.6 531.6 TOTAL SHAREHOLDERS' EQUITY AND LIABILITIES 524.6 1,507.5 1,114.8 Notes Accounting policies This report was prepared pursuant to IAS 34. Orexo applies IFRS ® Accounting Standards on its condensed consolidated financial statements. The accounting policies are in line with those used in the preparation of the 2025 Annual Report. None of the amended standards and interpretations effective as of 1 January 2026 have had significant impact on the Group's financial reporting and have not been applied in the preparation of these financial statements. The Parent Company's financial statements were prepared in accordance with RFR 2 (Swedish Financial Reporting Board's recommendation) and Chapter 9 of the Swedish Annual Accounts Act. Segment reporting As of Q1 2026, Orexo's management does not any more follow up the operations on a segment level, thus no segments are reported. Dispute On July 14, 2020, Orexo became aware of an investigation by the US authorities and the investigation is ongoing. Based on communications from the US authorities, the company believes the investigation concerns principally certain historic marketing messaging campaigns and whether they were compliant with law. Other areas of interest to the government are Orexo's selection of healthcare providers to market, as well as Orexo's voucher and co-pay programs. Orexo´s position is that Zubsolv has been promoted in a compliant and responsible manner, but Orexo is seeking a resolution. Orexo as of this date is not aware of any filed civil or criminal case related to the investigation. Deferred tax The tax effect of the Group's temporary differences are related to non-deductible current provisions for sales rebates, sales allowances, distribution, sales returns and other relevant deductions in the company's US operations. Deferred tax assets relates to intercompany profit in inventory, non-deductible current provisions for sales rebates, sales allowances, distribution, sales returns and other relevant deductions in the company's US operations. The tax-loss carry-forward in the Group amounts to SEK 1,258.7 m as of December 31, 2025 and refers to Swedish companies. Deferred tax assets for tax losses carried forward are only recognized to the extent that it is probable that taxable profits will be available against which the losses can be utilized. The Group's tax losses carried forward at the balance sheet date have not been recognized as deferred tax assets, as the recognition criteria under IAS 12 have not been met. There is no time limit for when the remaining loss carryforwards can be utilized. Financial instruments The Group's financial instruments consists of current receivables, non-current receivables, cash and cash equivalents, current non-interest bearing liabilities and current interest-bearing liabilities. The financial instruments held by the group are recognized at amortized cost using the effective interest method and discounted net present value. Earn out is measured at fair value level 3 (discounted net present value). Revaluations are reported under other income and expenses in operating profit. Significant input data affecting the valuation is primarily the buyer's actual sales of Zubsolv in 2026 and 2027. Related parties There have been no significant related parties transactions with related parties during the period other than sales of services between Biolipox AB and Orexo Inc, remuneration to the board, president and senior executives. All transactions have been made at at arm's length. Significant events after the end of the period No significant events after the end of the period. 3. Cash flow ADJUSTMENT FOR NON-CASH ITEMS SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Depreciation/amortization and impairment 8.8 11.1 67.0 Change in provisions -109.1 -12.3 55.7 Other non cash items -0.1 0.0 -0.8 Exchange rate income and expenses 1.1 7.1 12.3 Share-based payments 3.2 - 9.6 Total continued operation -96.0 5.9 143.8 9. Net revenue from contracts with customers 2026 Jan-Mar SEK m Zubsolv ® Abstral ® Edluar ® Vorvida ® MODIA ® Total Total revenue from contracts with customers 0.5 0.7 3.8 0.0 0.0 5.0 Geographical markets US - - 0.1 - - 0.1 EU & UK 0.5 0.7 2.9 - - 4.1 Rest of the world - - 0.9 - - 0.9 Total revenue from contracts with customers 0.5 0.7 3.8 0.0 0.0 5.0 2025 Jan-Dec SEK m Zubsolv ® Abstral ® Edluar ® Vorvida ® MODIA ® Total Total revenue from contracts with customers 9.2 4.0 12.8 0.0 0.0 26.0 Geographical markets US - - 1.0 0.0 - 1.0 EU & UK 9.2 4.3 9.3 - - 22.7 Rest of the world - -0.2 2.6 - - 2.4 Total revenue from contracts with customers 9.2 4.0 12.8 0.0 0.0 26.0 2025 Jan-Mar SEK m Zubsolv ® Abstral ® Edluar ® Vorvida ® MODIA ® Total Total revenue from contracts with customers 8.1 1.7 3.4 0.0 0.0 13.2 Geographical markets US - - 0.1 - - 0.1 EU & UK 8.1 1.9 2.9 - - 12.9 Rest of the world - -0.2 0.4 - - 0.2 Total revenue from contracts with customers 8.1 1.7 3.4 0.0 0.0 13.2 10. Discontinued operations Description On 31 December, 2025, Orexo closed the transaction with Dexcel Pharma USA acquiring the full rights to Zubsolv in the US. The upfront consideration paid at closing of the transaction amounted to USD 91 m plus the value of inventory of USD 3.8 m. USD 3 m has also been deposited into an escrow account in accordance with customary terms to secure the seller's obligations under the agreement. That leaves a Purchase price of USD 91.8 m (SEK 854.5 m). Furthermore, Orexo is entitled to a contingent consideration of up to USD 16.8 m, based on future net sales during 2026 and 2027. Discounted estimated contingent consideration amounts to SEK 75.9 m and is included in "Profit on sale of Zubsolv US business" in the Analysis below. Analysis of P&L and cash flow The income statement and cash flow information presented below relates to the periods ended March 31, 2025 and March 31, 2026, and the year ended December 31, 2025. Below reported costs for Q1 2026 are mainly post transaction related restructuring costs. ANALYSIS OF P&L AND CASH FLOW SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Zubsolv US product sales - 133.0 499.0 Cost of goods sold 0.1 -13.6 -39.7 Selling expenses -13.3 -40.8 -141.5 Administrative expenses -14.1 -2.9 -11.9 Research and development costs -4.9 -4.5 -17.0 Other operating income and expenses 3.5 - - Profit on sale of Zubsolv US business - - 769.1 Net financial items - - - Profit for discontinued operations before tax -28.7 71.1 1,058.0 Tax - 3.6 -15.4 Net earnings from discontinued operations -28.7 74.7 1,042.6 Net cash flow from operating activities -6.2 74.5 368.4 Net cash flow from investing activities -1.3 - 655.1 Net cash flow from financing activities - -1.1 - Net increase in cash and cash equivalents generated by discontinued operations -7.5 73.4 1,023.5 INFORMATION REGARDING DISCONTINUATION OF ZUBSOLV US BUSINESS SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Purchase price received or purchase price to be received: Agreed purchase price - - 854.5 Estimated earn-out - - 75.9 Total purchase price 0.0 0.0 930.4 Sold inventories - - -39.4 GTN items - - -77.3 FDA annual fee & patent - - -17.1 Fees for transaction advisors - - -40.9 Profit before tax and reclassifications of currency translations reserve 0.0 0.0 755.7 Reclassification of currency translation reserve - - 13.4 Profit from the sale after tax 0.0 0.0 769.1 SEK m 2026 Mar 31 Inventory - Total assets 0.0 Total liabilities 0.0 Net assets 0.0 Definitions and reconciliations of key figures KEY FIGURES AND CERTAIN OTHER OPERATING INFORMATION PER SHARE ARE DEFINED AS FOLLOWS Margins Definition/calculation Purpose Operating margin (EBITmargin) Operating earnings as a percentage of net revenues Operating profit margin is used for measuring the operational profitability Return Definition/calculation Purpose Return on equity Net earnings for the period as a percentage of average shareholders' equity Return on equity is used to measure profit generation, given the resources attributable to the owners of the Parent Company Capital structure Definition/calculation Purpose Net Debt Current and long-term interest-bearing liabilities including pension liabilities, less short-term investments and cash and cash equivalents The net debt is used as an indication of the ability to pay off all debts if these became due simultaneously on the day of calculation, using only available short-term investments and cash and cash equivalents Debt/equity ratio Interest bearing liabilities divided by shareholders' equity The debt/equity ratio measures how much debt a company is using to finance its assets relative to the amount of value represented in shareholder's equity. Working capital Current assets excluding cash and cash equivalents less current liabilities excluding interest bearing liabilities Working capital is used to measure the company's ability, besides cash and cash equivalents and interest bearing liabilities, to meet current operational obligations Capital employed Interest-bearing liabilities and shareholders' equity Capital employed measures the amount of capital used and serves as input for the return on capital employed Gross investments Value of investment before amortization Gross investments is a measure of the company's investments in tangible and intangible fixed assets Data per share Definition/calculation Purpose Number of shares after dilution Shares at the end of the period adjusted for the dilutive effect of potential shares Is used to calculate earnings per share after dilution Earnings per share, before dilution Net earnings for the period after tax divided by the average number of shares outstanding before dilution during the period The earnings per share before dilution measures the amount of net profit that is available for payment to its shareholders per share before dilution Earnings per share, after dilution Net earnings for the period after tax divided by the average number of shares outstanding after dilution during the period The earnings per share after dilution measures the amount of net profit that is available for payment to its shareholders per share after dilution. In the event of negative earnings per share, diluted earnings per share are reported as the same as earnings per share before dilution Other definitions Definition/calculation Purpose Operating expenses An expense incurred in daily operating activities. Expense related to financing is not considered part of daily operating activities. Operating expenses reflect costs for selling, administration, research and development, depreciation and other operating income and operating expenses EBIT Earnings before net financial items and tax, the same as Operating earnings This measure enables the profitability to be compared across locations where corporate taxes differ and irrespective the financing structure of the company EBITDA Earnings before interest, taxes, depreciation and amortization. EBIT plus depreciation and amortization Profit measure which is more closely correlated with cash flow as non-cash items like Depreciation and Amortization are excluded KEY FIGURES AND CERTAIN OTHER OPERATING INFORMATION ARE RECONCILED AS FOLLOWS EBITDA continued operation SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec EBIT -75.0 -76.3 -352.7 Depreciation and amortization 8.8 11.1 67.0 EBITDA continued operation -66.1 -65.2 -285.7 Return on shareholders' equity SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Shareholders' equity beginning balance 490.6 -126.3 -126.3 Shareholders' equity ending balance 364.7 -161.3 490.6 Average shareholders' equity 427.6 -143.8 182.2 Net earnings -133.9 -15.9 639.3 Return on shareholders' equity % -31.3 neg. 351.0 Net debt SEK m 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Current and long-term interest-bearing liabilities including pension liabilities - 460.8 483.1 Cash and cash equivalents. 386.2 119.1 912.4 Net debt -386.2 341.7 -429.2 Debt/equity ratio 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Interest-bearing liabilities - 460.8 483.1 Shareholders equity 364.7 -161.3 490.6 Debt/equity ratio % 0.0 neg. 98.5 Earnings per share continued operation. before dilution SEK 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Number of shares. before dilution 35,126,410 34,505,226 34,625,973 Net earnings for the period SEK m -105.2 -90.6 -403.3 Earnings per share. before dilution -3.00 -2.63 -11.65 Earnings per share continued operation, after dilution SEK 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Number of shares, after dilution 39,593,836 34,505,226 39,553,329 Net earnings for the period SEK m -105.2 -90.6 -403.3 Earnings per share, after dilution 4 -2.66 -2.63 -10.20 4 Due to negative values, diluted earnings per share are reported using the same values as for earnings per share before dilution in other tables in the report. Research and development expenses/operating expenses 2026 Jan-Mar 2025 Jan-Mar 2025 Jan-Dec Selling expenses 0.1 -1.7 -14.6 Administrative expenses -37.5 -30.4 -110.7 Research and development costs -50.1 -47.1 -233.1 BARDA reimbursement OX390 7.1 - 1.4 Research and development costs less BARDA reimbursement -43.0 -47.1 -231.7 Other operating income and expenses less BARDA reimbursement 0.9 -5.6 -7.4 Operating expenses -79.5 -84.7 -364.3 Of which research and development expenses/operating expenses, % 54.1 55.6 63.6 Main office Subsidiary Orexo AB P.O. Box 303 751 05 Uppsala Sweden Orexo US Inc. 1 Gatehall Drive Suite 309 Parsippany, NJ 07054 United States [email protected] us.orexo.com Orexo is a Swedish biotechnology company dedicated to advance treatments for severe diseases and life-saving rescue medications to meet future healthcare needs. At the core of our innovation is AmorphOX®, a proprietary drug delivery technology that improves bioavailability and stability for both large and small molecules, enabling new approaches to administration, manufacturing, and distribution. With over 30 years of experience and multiple drugs approved globally, Orexo is advancing a diversified pipeline of programs in clinical and pre-clinical development. The company collaborates with partners in research, development, and commercialization. Headquartered in Uppsala, Sweden, Orexo is listed on Nasdaq Stockholm's main market and trades as ADRs on the OTCQX market in the United States. For more information please visit https://www.orexo.com . You can also follow Orexo on X, LinkedIn, and YouTube.