The data of SNS812, an anti-Pan-COVID19 siRNA, co-developed by Oneness & MBS and supervised by NTU professors, were published today by EMBO Mol. Medicine
· Issued by Oneness Biotech Co., Ltd.
Close
Today's Information
Provided by: ONENESS BIOTECH CO., LTD.
SEQ_NO
1
Date of announcement
2022/02/21
Time of announcement
23:23:34
Subject
The data of SNS812, an anti-Pan-COVID19 siRNA,
co-developed by Oneness & MBS and supervised by NTU
professors, were published today by EMBO Mol. Medicine
Date of events
2022/02/21
To which item it meets
paragraph 53
Statement
1.Date of occurrence of the event:2022/02/21
2.Company name:ONENESS BIOTECH CO., LTD.
3.Relationship to the Company (please enter "head office" or
"subsidiaries"):head office
4.Reciprocal shareholding ratios:NA
5.Cause of occurrence:
SNS812 is a siRNA new drug targeting a highly conserved region of SARS-CoV-2.
Unlike traditional antiviral agents, such as nucleoside analog
(eg. molnupiravir) or proteinase inhibitor (eg. paxlovid) which inhibits
the virus by interrupting replication or interfering protein maturation,
SNS812 directly and specifically cleaves and destroys the viral RNA by a
special mechanism called RNA interference. The analysis indicates that
SNS812 is capable to cover 99.8% of SARS-CoV-2 variants and has the highest
coverage rate among all currently available medicines. SNS812 can inhibit
original(A.3) ,Alpha, Beta, Gamma, Epsilon and Delta strains with pM range
of IC50 in vitro,and effectively prevent or treat SARS-CoV-2 infection in
hACE2 transgenic mice.Furthermore, SNS812 is highly specific to the virus,
which represents non-immunogenicity and safety in animal toxicity studies
and thus potentially reduce treatment risk and side effects compared with
other small-molecule drugs.
The research article has been accepted by EMBO Molecular Medicine and
published on 2022/02/21
6.Countermeasures:None
7.Any other matters that need to be specified:
(1)European Molecular Biology Organization (EMBO) is a professional
organization with strong influence to promote research in life science
and enable international communication between scientists. EMBO has been
well-known for its rigorous review and high quality of publication. EMBO
Molecular Medicine has the highest impact factor (IF: 12.137) among EMBO
series of journals. Moreover, EMBO Molecular Medicine is ranked the 7th
of 140 journals in the category of Medicine, Research and Experimental
and top 5% of all journals. The article of SNS812 can be accessed:
https://www.embopress.org/doi/full/10.15252/emmm.202115298.
(2)The publication of the study results of SNS812 in EMBO Molecular Medicine
represents the acknowledgement by the top international journal not only
on the research and development of siRNA drug, but also on the
scientific evidence and therapeutic potential of SNS812 for the
treatment of COVID-19。
(3)The trend of SARS-CoV-2 infection is gradually becoming flu-like, so the
development of therapeutic drugs is critically needed. SNS812 is a
broad-spectrum siRNA with both therapeutic and preventive efficacy against
a wide range of variants of SARS-CoV-2. The goal is to develop a
pan-COVID-19 therapeutic for the pandemic.
(4)SNS812 is currently under cGMP product with the CMO followed by toxicology
studies with the CRO. It has been planned to submit the IND application to
the US FDA in the middle of 2022.
(5)The development of new drugs is with great risks. The promising data in
animal studies do not guarantee the clinical success.
