New Healthcare Claims Study Published in CNS Spectrums Finds High Rates of Treatment Switching, Discontinuation, and Prolonged Gaps in Care Among Patients with Generalized Anxiety Disorder (GAD)

About this update from Definium Therapeutics, Inc.

Data highlight the challenges of achieving response and sustained remission in newly diagnosed and established GAD patients with existing therapies NEW YORK, July 14, 2026 --( BUSINESS WIRE )--Definium Therapeutics, Inc. (Nasdaq: DFTX) ("Definium" or the "Company"), a late-stage clinical biopharmaceutical company developing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders, today announced results from a new healthcare claims study of treatment patterns of newly diagnosed and established GAD patients, including pharmacotherapy use, discontinuation, switching and treatment progression. The findings, published in CNS Spectrums, highlight the challenges in achieving response and sustained remission with existing treatments and underscore the need for new GAD treatments that provide better efficacy, rapid onset, sustained symptom control, and improved tolerability. The study highlights substantial unmet need in GAD treatment, revealing frequent treatment discontinuation, switching, and prolonged gaps in care that often occur well before the 6–12 months of therapy recommended in clinical guidelines to reduce relapse risk. Specifically, the analysis found: "GAD affects approximately 1 in 10 adults in the U.S., and our analysis shows that for many of them, current treatments simply aren't delivering with many patients struggling to remain on treatment. More than half of newly diagnosed patients who stopped therapy never restarted during the study follow-up. We can't close that gap without better options," said Roger S. McIntyre, MD, FRCPC, co-author and Professor of Psychiatry and Pharmacology at the University of Toronto. "Behind every statistic is a person who has not achieved the symptomatic relief that's meaningful for them, often leading them to stop treatment and providing impetus for us to discover innovative new treatments."

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