New Data Shows CK1d Blocks Tau in AD Model

About this update from Proteome Sciences Plc

RNS Number : 5620J Proteome Sciences PLC 18 July 2013   Proteome Sciences plc   New Data Shows CK1d Blocks Tau in AD Model   18th July 2013, Cobham, UK:  Proteome Sciences yesterday made two poster presentations showing new data and results from its novel casein kinase 1 delta (CK1d) inhibitor program in Alzheimer's disease.  The results show that the two lead compounds are orally available, attain therapeutic levels in the brain of experimental Alzheimer's models and improve cognitive behaviour.  When the tau protein of treated animals was analysed a decrease was seen at key sites in total tau deposition and in tau phosphorylation.  Treatment also caused a dramatic drop in the amount of the target protein in the brain.  Taken together these data show that inhibition of CK1d acts through multiple mechanisms to reduce the amount of pathological tau protein which is increasingly recognised as a major goal for effective Alzheimer's disease treatments.   Commenting on the results, Dr. Ian Pike, COO of Proteome Sciences plc and presenting author of the posters said:   "Having our posters selected for presentation at AAIC reflects the recognition and potential of our CK1d inhibitor program for treating Alzheimer's disease and other tauopathies.  The latest results provide a strong mechanistic basis for the improved cognition seen in treated animals.  As the pharmaceutical industry is increasing the search for new targets beyond beta-amyloid our ability to reduce tau pathology is very timely and will enhance our ongoing discussions to outlicense our CK1d program to the right pharmaceutical partner."   - Ends -   For further information please contact: Proteome Sciences plc Christopher Pearce, Chief Executive Officer Tel: +44 (0)1932 865065 Dr. Ian Pike, Chief Operating Officer James Malthouse, Finance Director Nominated Adviser Cenkos Stephen Keys/Camilla Hume Tel: +44 (0)20 7397 8900 Public Relations IKON Associates Adrian Shaw Tel: +44 (0)1483 271291   Notes to Editors: About Proteome Sciences Proteome Sciences is a global leader in applied proteomics and peptidomics offering high sensitivity, proprietary technologies for protein and peptide biomarker discovery, validation and assay development. Its PS Biomarker Services™ uses isobaric and isotopic Tandem Mass Tag® (TMT®) workflows...

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