Findings published in Neurology® show improvements in upper-limb motor function, activities of daily living, and quality of life were sustained for at least two years
AUSTIN, Texas, July 14, 2026 (GLOBE NEWSWIRE) -- Mobia Medical, Inc. (Nasdaq: MOBI), a commercial-stage medical device company redefining stroke recovery for survivors living with life-altering motor impairments, today announced the publication of two-year follow-up data from the VNS-REHAB study in Neurology®, the official peer-reviewed journal of the American Academy of Neurology. The findings demonstrate that statistically significant and clinically meaningful improvements in upper-limb motor impairment and function, ability to perform activities of daily living, and quality of life were sustained for at least two years following completion of in-clinic Vivistim® Paired VNS™ Therapy. With its publication, this data now represents some of the most comprehensive longitudinal evidence to date for any intervention approved for chronic ischemic stroke recovery.
The two-year follow-up data, published in Neurology, reports outcomes from 49 participants in the VNS-REHAB pivotal trial, demonstrating a high responder rate and substantial improvements in impairment and function including:
Clinically meaningful response on the Fugl-Meyer Assessment of Upper Extremity impairment (FMA-UE) and/or the Wolf Motor Function Test (WMFT) in 76% of participants
Average improvement of +7.5 points from baseline on the FMA-UE, exceeding the minimum clinically important difference (MCID) of ≥6 points
Average improvement of +0.63 from baseline on the WMFT, exceeding the MCID of ≥0.4 points
Importantly, these upper-limb motor improvements also translated into impactful real-world changes in the daily lives of stroke survivors. Participants demonstrated statistically significant and clinically meaningful improvements across multiple patient-reported measures of activity, participation, and quality of life, including:
Ability to perform activities of daily living, such as bathing and dressing (Activities of Daily Living subscale of the Stroke Impact Scale; SIS-ADL)
Perceived ease of performing daily activities with the affected hand and arm, such as carrying heavy objects or tying shoelaces (Hand subscale of the Stroke Impact Scale; SIS-Hand)
Amount of use and quality of movement of the affected hand and arm when performing activities of daily living, such as brushing teeth or typing (Motor Activity Log; MAL)
Overall stroke-specific quality of life, such as mood, self-care, social participation and family roles (Stroke-Specific Quality of Life Scale; SS-QOL)