Healthcare
METiS TechBio and Boulevard Bio Enter Global License Agreement for Trispecific T-cell Engager
METiS TechBio (7666.HK), a leading AI-driven drug delivery innovation company, today announced it has entered into an exclusive global licensing agreement with Boulevard Bio ("Boulevard"), a U.S. biotechnology company backed by Deerfield Management, granting Boulevard worldwide development, manufacturing, and commercialization rights for MTS-128, a proprietary trispecific T-cell engager (TCE) program developed by METiS TechBio.
About this update from Metis Techbio Co., Ltd. Class H
HONG KONG and NEW YORK, June 30, 2026 /PRNewswire/ -- METiS TechBio (7666.HK), a leading AI-driven drug delivery innovation company, today announced it has entered into an exclusive global licensing agreement with Boulevard Bio ("Boulevard"), a U.S. biotechnology company backed by Deerfield Management, granting Boulevard worldwide development, manufacturing, and commercialization rights for MTS-128, a proprietary trispecific T-cell engager (TCE) program developed by METiS TechBio. METiS TechBio will receive a $20 million upfront payment and is eligible to receive up to $1.6 billion in development, regulatory, and commercial milestone payments, in addition to tiered royalties on product sales. METiS TechBio's proprietary NanoForge platform has achieved deep integration across AI-based protein design, drug delivery system engineering, and therapeutic innovation, reflecting validation from top-tier global capital and industry partners. This transaction marks a shift in AI-enabled drug delivery platforms from early technological validation toward global commercialization value realization. MTS-128 is a next-generation trispecific T-cell engager developed by METiS TechBio through its NanoForge platform. Unlike traditional antibody discovery approaches, MTS-128 is designed and optimized end-to-end through NanoForge-enabled AI-driven molecular engineering, representing a key example of AI-enabled therapeutic innovation at METiS TechBio. Compared with conventional bispecific T-cell engagers, trispecific TCEs can simultaneously engage multiple biological mechanisms, with the potential to enhance target cell killing efficiency, increase therapeutic window and reduce off-target toxicity. The development of MTS-128 reflects METiS TechBio's integrated capabilities in artificial intelligence and protein engineering, while also demonstrating NanoForge's ability to continuously generate novel therapeutic assets. METiS TechBio's proprietary AI-enabled nanodelivery platform, NanoForge, is built on an integrated "dry lab + wet lab + agent-based intelligence" innovation framework, powering four core solution engines: AiLNP (AI-driven lipid nanoparticle design), AiRNA (AI mRNA sequence design), AiProtein (AI protein and antibody design), and AiTEM (AI small molecule formulation design). NanoForge enables an end-to-end innovation chain spanning AI-based protein generation, in ...
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