Landmark study of 2,470 patients across two U.S. health systems demonstrates sustained risk-stratified improvements in kidney function, increases in guideline-directed therapy uptake, and - for the first time - measurable reduction in individual patient risk trajectories over 24 months
NEW YORK, June 30, 2026 /PRNewswire/ -- Renalytix PLC (LSE: RENX) (OTCQB: RNLXY), a precision medicine diagnostics company, today announced results published in the peer-reviewed medical journal Diabetes, Obesity and Metabolism from its most comprehensive real-world evidence (RWE) study to date for its FDA-approved kidneyintelX.dkd test.
Spanning 2,470 patients with type 2 diabetes and early-stage chronic kidney disease (CKD) across two major U.S. health systems, Mount Sinai Health System in New York and Wake Forest/Atrium Health in North Carolina, the IRB-approved prospective study reveals that kidneyintelX.dkd not only transforms how clinicians assess risk but changes the course of disease over a full two year period, a first for any kidney prognostic tool.
"These two-year data provide the clearest real-world picture yet of what risk stratification can do when applied consistently at scale in two large health systems. What we see is that a structured, biomarker-guided approach to prescribing translates into targeted therapy decisions — higher-risk patients receiving more intensive treatment, and lower-risk patients largely spared unnecessary escalation. That is what precision medicine is supposed to look like in practice."
- Dr David Lam, Co-Principal Investigator
Endocrinologist with the Mount Sinai Health System
A LEAP BEYOND PRIOR EVIDENCE
The KidneyIntelX real-world evidence program has evolved from the 6- to 12- to 24-month time periods, demonstrating sustainable clinical improvements tied to how the test's risk stratification successfully informs guideline-directed medical treatment (GDMT).
6-Month RWE: Established that KidneyIntelX risk results changed clinician decision-making and GDMT in a real-world setting.
12-Month RWE: Confirmed that these changes in risk-stratified GDMT were associated with meaningful improvements in kidney, cardiac, and metabolic markers (eGFR slope, UACR, HbA1c, blood pressure).
Just released 24-Month RWE data demonstrates: (1) that KidneyIntelX is a dynamic, longitudinal risk tool, not just a one-time test; (2) that blood-based biomarkers strongly influence changes in risk level; (3) robust independent prognostic performance in two contemporary care settings, and (4) GDMT (e.g., SGLT2 inhibitors and GLP1 receptor agonists) use is significantly increased post-baseline risk assessment.