Syncona Ltd GBPLSE: SYNC

Syncona Ltd GBP: Holding(s) in Company

· Issued by Syncona Ltd GBP via RNS

TR-1: Standard form for notification of major holdings

1. Issuer Details

ISIN

GG00B8P59C08

Issuer Name

SYNCONA LIMITED

UK or Non-UK Issuer

UK

2. Reason for Notification

An acquisition or disposal of voting rights; An acquisition or disposal of financial instruments

3. Details of person subject to the notification obligation

Name

Jefferies Financial Group Inc

City of registered office (if applicable)

Country of registered office (if applicable)

US

4. Details of the shareholder

Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above

City of registered office (if applicable)

Country of registered office (if applicable)

5. Date on which the threshold was crossed or reached

19-Oct-2026

6. Date on which Issuer notified

20-Oct-2026

7. Total positions of person(s) subject to the notification obligation

% of voting rights attached to shares (total of 8.A)

% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)

Total of both in % (8.A + 8.B)

Total number of voting rights held in issuer

Resulting situation on the date on which threshold was crossed or reached

0.001000

6.738000

6.739000

40953811

Position of previous notification (if applicable)

0.148000

5.916000

6.064000

8. Notified details of the resulting situation on the date on which the threshold was crossed or reached

8A. Voting rights attached to shares

Class/Type of shares ISIN code(if possible)

Number of direct voting rights (DTR5.1)

Number of indirect voting rights (DTR5.2.1)

% of direct voting rights (DTR5.1)

% of indirect voting rights (DTR5.2.1)

GG00B8P59C08

4490

0.001000

Sub Total 8.A

4490

0.001000%

8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))

Type of financial instrument

Expiration date

Exercise/conversion period

Number of voting rights that may be acquired if the instrument is exercised/converted

% of voting rights

Stock Loan/Repo Right of Recall

Open

18722683

3.080000

Sub Total 8.B1

18722683

3.080000%

8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))

Type of financial instrument

Expiration date

Exercise/conversion period

Physical or cash settlement

Number of voting rights

% of voting rights

Swap

09/11/2026

Cash

1000000

0.165000

Swap

18/02/2027

Cash

1500000

0.247000

Swap

24/12/2026

Cash

1500000

0.247000

Swap

23/12/2026

Cash

18226638

2.999000

Sub Total 8.B2

22226638

3.658000%

9. Information in relation to the person subject to the notification obligation

2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)

Ultimate controlling person

Name of controlled undertaking

% of voting rights if it equals or is higher than the notifiable threshold

% of voting rights through financial instruments if it equals or is higher than the notifiable threshold

Total of both if it equals or is higher than the notifiable threshold

Jefferies Financial Group Inc.

Jefferies International Limited

0.001000

6.738000

6.739000%

10. In case of proxy voting

Name of the proxy holder

The number and % of voting rights held

The date until which the voting rights will be held

If date does not apply, explain below

11. Additional Information

12. Date of Completion

20-Oct-2026

13. Place Of Completion

London, United Kingdom

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