Holding(s) in Company

About this update from Probiotix Health Plc

5 February 2026                                                                                                                         ProBiotix Health plc ("ProBiotix Health" or the "Company" or, together with its subsidiary, the "Group")   Shareholding in the Company   ProBiotix Health plc (AQSE: PBX), the life sciences business developing probiotics to support cardiometabolic health, has received a TR-1 form, which is reproduced without amendment below. TR-1: Standard form for notification of major holdings 1. Issuer Details ISIN GB00BLNBFR86 Issuer Name ProBiotix Health Plc UK or Non-UK Issuer UK 2. Reason for Notification An acquisition or disposal of voting rights 3. Details of person subject to the notification obligation Name SENECA PARTNERS LIMITED City of registered office (if applicable)   Country of registered office (if applicable) UK 4. Details of the shareholder Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above PLATFORM SECURITIES NOMINEES LIMITED WOODSIDE NOMINEES LIMITED City of registered office (if applicable) LONDON Country of registered office (if applicable) UK 5. Date on which the threshold was crossed or reached 04-FEB-2026 6. Date on which Issuer notified 05-FEB-2026 7. Total positions of person(s) subject to the notification obligation % of voting rights attached to shares (total of 8.A) % of voting rights through financial instruments (total of 8.B 1 + 8.B 2) Total of both in % (8.A + 8.B) Total number of voting rights held in issuer Resulting situation on the date on which threshold was crossed or reached 4.9976 0.000000 4.9976 7,904,583 Position of previous notification (if applicable) 6.6 0.000000 6.6 8,025,450 8. Notified details of the resulting situation on the date on which the threshold was crossed or reached 8A. Voting rights attached to shares Class/Type of shares ISIN code(if possible) Number of direct voting rights (DTR5.1) Number of indirect voting rights (DTR5.2.1) % of direct voting rights (DTR5.1) % of indirect voting rights (DTR5.2.1) GB00BLNBFR86       7,904,583 4.9976 Sub Total 8.A 7,904,583 4.9976 8B1. Financial Instruments according to (DTR5.3.1R.(1) (a)) Type of financial instrument Expiration date Exercise/conversion period Number of voting rights that may be acquired if the instrument is exercised/converted % of voting rights   Sub Total 8.B1 8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b)) Type of financial instrument Expiration date Exercise/conversion period Physical or cash settlement Number of voting rights % of voting rights   Sub Total 8.B2 9. Information in relation to the person subject to the notification obligation 1. Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer. Ultimate controlling person Name of controlled undertaking % of voting rights if it equals or is higher than the notifiable threshold % of voting rights through financial instruments if it equals or is higher than the notifiable threshold Total of both if it equals or is higher than the notifiable threshold   10. In case of proxy voting Name of the proxy holder   The number and % of voting rights held   The date until which the voting rights will be held   11. Additional Information The previous notification at 6.6% was made on 1 April 2022. The decrease to the current position reflects an orderly sell-down over several years and dilution resulting from increases in the issuer's share capital, with the 5% threshold crossed on 4 February 2026. 12. Date of Completion 05-02-2026 13. Place Of Completion Haydock UK

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