Gilead to Present New Data Advancing Care in PBC and Viral Hepatitis at EASL 2026

About this update from Gilead Sciences, Inc.

- Late-Breaking Livdelzi (Seladelpar) Data Expand the Evidence Base in PBC, while Interim Data Show Durable, Consistent Results Across Key Markers - - Bulevirtide Data Strengthen Evidence of Efficacy and Safety Across Broad HDV Populations - - New Findings Highlight Progress Toward HCV Elimination and Improved HDV Risk Insight - FOSTER CITY, Calif., May 13, 2026 --( BUSINESS WIRE )--Gilead Sciences, Inc. (Nasdaq: GILD) will present findings from 29 abstracts, including late-breaking presentations at the European Association for the Study of the Liver (EASL) Congress, May 27-30, 2026, Barcelona. These presentations advance understanding of primary biliary cholangitis (PBC) and viral hepatitis. In PBC, Gilead will present randomized and long-term study data for Livdelzi® (seladelpar), known as Lyvdelzi ® in the European Union. Together these data provide a multidimensional view of Livdelzi’s efficacy, safety and durability across a broad PBC population. Livdelzi is a first‑in‑class delpar (selective PPAR‑delta agonist) indicated for the treatment of PBC to be used in combination with ursodeoxycholic acid (UDCA) for those with an inadequate response to UDCA, or as monotherapy for patients unable to tolerate UDCA. "Primary biliary cholangitis is a chronic, progressive disease where reducing disease activity is critical to improving long‑term outcomes. Minimizing impact on quality of life is also key for people living with PBC," said Swati Tole, MD, MS, Senior Vice President, Clinical Development, Inflammation at Gilead Sciences. "At EASL, we are sharing data that further define Livdelzi’s potential to address both disease activity and symptoms such as pruritus." Advancements in Hepatitis Delta Virus Presentations will also focus on hepatitis delta virus (HDV), a severe co‑infection in people with chronic hepatitis B. The program will include several analyses evaluating investigational bulevirtide, a first‑in‑class entry inhibitor, in diverse HDV patient populations, reflecting continued efforts to better understand HDV disease management and treatment approaches. "People living with HDV face a severe disease with limited treatment options. These analyses highlight the breadth of ongoing research and Gilead’s continued leadership in advancing the understanding of HDV, including efforts to evaluate Hepcludex across diverse patient populations," said Jared Baeten, MD, PhD, Senior Vice President, Clinical Development, Virology at Gilead Sciences. "We remain committed to continuously building on emerging evidence to help improve how this disease is managed over time, and we encourage clinicians to engage with evolving data to help inform care for people living with HDV." Analyses from Phase 2 and Phase 3 studies, including MYR301 ( NCT03852719 ) and MYR204 ( NCT03852433 ) will evaluate clinical, virologic, and biochemical outcomes, as well as safety and tolerability, through 96 weeks across HDV subgroups. An additional study uses a machine‑learning model to identify risk factors for progression to advanced liver disease in adults with HDV infection in the United States. Advancing Equitable Care for Hepatitis B and C Additional presentations highlight progress across viral hepatitis, including HBV cure research, long‑term disease management, and HCV elimination efforts. Key Abstracts at EASL 2026: For more information, including a complete list of abstract titles being presented at the meeting, please visit the EASL website . Please see below for the U.S. Indications and Important Safety Information for Livdelzi. Marketing Authorizations for Bulevirtide In July 2023, the European Commission granted full Marketing Authorization (MA) for Hepcludex (bulevirtide) 2 mg for the treatment of adults with chronic hepatitis delta virus (HDV) infection and compensated liver disease (conditional approval was received in July 2020). Hepcludex 2 mg also has full marketing authorization in the United Kingdom, Switzerland, Australia, Canada, United Arab Emirates, Israel and Kuwait. Bulevirtide is not approved in the United States. In the U.S. and other regions where it is not authorized, bulevirtide 2 mg is an investigational product, and its safety and efficacy have not been established or approved by the U.S. Food and Drug Administration (FDA) or other health authorities. Bulevirtide 10 mg, GS-2328 and GS-6779 are investigational and not approved anywhere globally. The safety and efficacy of these programs have not been established. U.S. Indication for Livdelzi Livdelzi is indicated for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults who have had an inadequate response to UDCA, or as monotherapy in patients unable to tolerate UDCA. The FDA approved this indication under accelerated approval based on a reduction of alkaline phosphatase (ALP). Improvement in survival or prevention of liver decompensation events have not been demonstrated. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s). Limitations of Use for Livdelzi: Use of Livdelzi is not recommended in patients who have or develop decompensated cirrhosis (e.g., ascites, variceal bleeding, hepatic encephalopathy). U.S. Important Safety Information for LIVDELZI Warnings and Precautions Adverse Reactions Drug Interactions Pregnancy and Lactation About Gilead Sciences in Liver Disease For decades, Gilead has pioneered the way forward to improve the lives of people living with liver disease around the world. We have helped to transform hepatitis C from a chronic condition into one that can be cured for millions of people. For people living with hepatitis B or D, our focus on advancing our medicines drives hope that today’s research will turn into tomorrow’s cures. Beyond viral hepatitis, we’re working to deliver advanced treatments for people living with PBC. But our commitment doesn’t stop there. Through our ground-breaking science and collaborative partnerships, we strive to create healthier futures for everyone living with liver disease. We are committed to a future without liver disease. About Gilead Sciences Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, cancer and inflammation. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California. Forward-Looking Statements This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other factors, including Gilead’s ability to initiate, progress or complete clinical trials or studies within currently anticipated timelines or at all, and the possibility of unfavorable results from ongoing or additional clinical trials or studies, including those involving bulevirtide, Livdelzi, GS-2829 and GS-6779 (such as RESPONSE, ASSURE, MYR301 and MYR204); uncertainties relating to regulatory applications and related filing and approval timelines, including additional pending and potential applications for programs and/or indications currently under evaluation, and the risk that any such approvals, if granted, may be subject to significant limitations on use or subject to withdrawal or other adverse actions by the applicable regulatory authority; the possibility that Gilead may make a strategic decision to discontinue development of these programs and, as a result, these programs may never be successfully commercialized for the indications currently under evaluation; and any assumptions underlying any of the foregoing. These and other risks, uncertainties and factors are described in detail in Gilead’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2026, as filed with the U.S. Securities and Exchange Commission. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. The reader is cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties and is cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements are based on information currently available to Gilead, and Gilead assumes no obligation and disclaims any intent to update any such forward-looking statements. Hepcludex, Livdelzi, Lyvdelzi, Gilead and the Gilead logo are registered trademarks of Gilead Sciences, Inc., or its related companies. U.S. full Prescribing Information for Livdelzi is available at www.gilead.com . For more information about Gilead, please visit the company’s website at www.gilead.com , follow Gilead on X/Twitter (@Gilead Sciences) and LinkedIn (@Gilead-Sciences). View source version on businesswire.com: https://www.businesswire.com/news/home/20260512412079/en/ Contacts Priscilla White, Media [email protected] Jacquie Ross, Investors [email protected]

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