Directors Shareholdings

EpiStem Holdings plc 28 June 2007 EpiStem Holdings plc 28 June 2007 Directors Shareholdings EpiStem Holdings Plc (the 'Company'), was notified today that on 27 June 2007 the Jeffrey G. Moore Charitable Remainder Unitrust, a U.S. based trust in which Jeffrey Moore, a Director of the Company, is a beneficiary, purchased 14,500 ordinary shares of 1.5p each at a cost of $50,025.00, a price of £1.72 ($3.45) each. As a result Dr. Jeffrey Moore is interested in 14,500 ordinary shares, representing less than 0.01% of the total voting rights. ENDS EpiStem Holdings Plc Teather & Greenwood Ltd John Rylands Thilo Hoffmann/Simon Brown Financial Director and Company Secretary Tel: +44 (0) 161 606 7258 Tel: +44 (0) 20 7426 7710 This information is provided by RNS The company news service from the London Stock Exchange