AstraZeneca PLCLSE: AZN

AstraZeneca: Director/PDMR Shareholding

· Issued by AstraZeneca PLC

22 December 2025

Transaction by Person Discharging Managerial Responsibilities

AstraZeneca PLC (the Company) announces that, on 18 December 2025, it was notified of a transaction in the Company's ordinary shares of $0.25 each (Ordinary Shares), by Nazneen Rahman, Non-Executive Director, on 18 December 2025, as set out below.

PDMR 

Position 

Nature of the transaction 

Quantity 

Price per Ordinary Share

Nazneen Rahman

Non-Executive Director

Sale of Ordinary Shares 

297

£134.96

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (as it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018.

1

Details of the person discharging managerial responsibilities / person closely associated

a)

Name

Nazneen Rahman

2

Reason for the notification

a)

Position/status

Non-Executive Director

b)

Initial notification/Amendment

Initial notification

3

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

AstraZeneca PLC

b)

LEI

PY6ZZQWO2IZFZC3IOL08

4i

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial instrument, type of instrument

Identification code

Ordinary Shares of US$0.25 each in AstraZeneca PLC

GB0009895292

b)

Nature of the transaction

Sale of Ordinary Shares of US$0.25 each in AstraZeneca PLC

c)

Price(s) and volume(s)

Price(s)

Volume(s)

£134.96

297

d)

Aggregated information

- Aggregated volume

- Price

Not applicable - single transaction

e)

Date of the transaction

18 December 2025

f)

Place of the transaction

LON

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca's innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit www.astrazeneca.com and follow the Company on social media @AstraZeneca.

Contacts

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Matthew Bowden

Company Secretary
AstraZeneca PLC

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