New data demonstrate the risk-stratification performance and potential of the TissueCypher® Barrett’s Esophagus test to guide risk-aligned patient care decisions
FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its three posters at the recent DDW Annual Meeting were honored as “Posters of Distinction” by the AGA Institute Council, ranking among the top 10% of the more than 3,100 abstracts showcased during the meeting.
“We are incredibly proud that all three of our posters presented at the recent DDW Annual Meeting received 'Poster of Distinction' honors,” said Robert Cook, Ph.D., senior vice president of research and development at Castle Biosciences. “We believe this signifies the value of our TissueCypher test in providing objective risk-stratification that can inform improved management decisions for patients with Barrett’s esophagus (BE).”
Following are highlights of Castle’s “Posters of Distinction” at DDW 2023. Full-text abstracts will be published in the May online supplement to Gastroenterology; the posters are available on the DDW ePosters site under Posters of Distinction category, Esophageal Diseases.
Poster # Tu1272: A Tissue Systems Pathology Test Objectively Risk-Stratifies Patients with Barrett’s Esophagus: Results from a Multicenter U.S. Clinical Experience Presenter: Study Author, Michael Yodice, M.D., Geisinger Health
TissueCypher test results from 2,456 BE patients ordered by 273 physicians at 32 academic centers and 161 community centers between June 2016 and October 2022 were evaluated in the study. TissueCypher risk-stratified patients in each pathologic (non-dysplastic BE (NDBE), indefinite for dysplasia (IND) and low-grade dysplasia (LGD)) and clinicopathologic (females, males, short-segment BE and long-segment BE) subset. Intermediate-risk TissueCypher scores in NDBE patients predicted a five-year risk of progression to high-grade dysplasia (HGD)/esophageal adenocarcinoma (EAC) of 6.2%, which was similar to the progression risk of 4.8% in patients with LGD in this community-based cohort, as well as published estimates. High-risk TissueCypher scores in NDBE patients predicted a five-year progression risk of 9.9%, which is higher than published estimates of progression in expert pathologist confirmed LGD.
Overall, the study data indicate that TissueCypher’s objective risk-stratification has significant, independent clinical utility to improve management decisions for BE patients in surveillance. The test can increase the early detection of progressors with NDBE and can enable clinicians and patients to consider risk-aligned management options to improve patient health outcomes.
Poster # Tu1271: A Tissue Systems Pathology Test Enables Standardized, Risk-Aligned Management of Patients with Barrett’s Esophagus Presenter: Senior Author, Jacques Bergman, M.D., Ph.D., Amsterdam University Medical Centers
The real-world pathology diagnoses, expert review diagnoses, TissueCypher test results and patient outcomes were collected for 699 patients from five completed clinical validation studies. Management decisions were then simulated using the real-world diagnoses with expert review of LGD, with or without guidance from TissueCypher test results.
In this simulation study in a cohort of 699 patients with known clinical outcomes, the TissueCypher test demonstrated significant clinical utility, particularly in patients with NDBE, enabling more progressors to be appropriately managed with endoscopic eradication therapy (EET) to prevent progression, or short interval surveillance, which are highly effective management strategies to improve BE patient health outcomes. In patients with NDBE, the percentage of progressors receiving appropriate management increased from zero, using standard of care (SOC) pathology review alone to guide patient management, to 57% when TissueCypher test results were used with the SOC to guide decisions (p