Boehringer Ingelheim’s oncology portfolio shows strong promise across multiple cancers at ASCO 2026

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Not intended for US and UK media Ingelheim, Germany and Ridgefield, Conn., US  –   At the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, Boehringer Ingelheim will present new data from across its robust oncology clinical development program. Key data includes patient-reported outcomes with HERNEXEOS ® (zongertinib tablets) as an initial orally administered treatment option for HER2 ( ERBB2 )-mutant advanced non-small cell lung cancer (NSCLC) and early results evaluating zongertinib in other types of cancer driven by HER2 alterations. 1-4 Updated data for obrixtamig, an investigational DLL3/CD3-targeting T-cell engager, will also be presented in extensive-stage small cell lung cancer (ES-SCLC) and extrapulmonary neuroendocrine carcinoma (epNEC). 5-6   “In the past year, Boehringer has meaningfully advanced the NSCLC treatment landscape through multiple regulatory approvals of zongertinib across markets. These new patient-reported outcomes for zongertinib further add to the growing body of evidence characterizing its clinical profile,” said Itziar Canamasas, Ph.D., Global Head of Oncology at Boehringer Ingelheim. “Building on this progress, our ambition is to advance precision cancer care across tumor types and modalities by exploring zongertinib’s potential in other HER2-driven cancers as well as next-generation approaches such as T-cell engagers. At ASCO, these data reflect our commitment to understanding what truly matters to patients, as we continue to shape an innovative oncology portfolio designed to deliver meaningful, unprecedented impact for people facing cancer.” Showcasing patient-reported outcomes for zongertinib in HER2-mutant NSCLC New patient-reported outcomes (N=71) from the Phase Ib Beamion LUNG-1 trial ( NCT04886804 ) showed improvements within one week of treatment in patients’ physical functioning with zongertinib as an initial treatment for adult patients with HER2 ( ERBB2 )-mutant advanced NSCLC, building on the efficacy and safety data that supported the recent U.S. FDA accelerated approval . 1 Results showed: “For people living with HER2-mutant advanced NSCLC, it’s especially important to understand how treatment affects how they feel and function in daily life,” said Dr. Joshua K. Sabari, study investigator and Associate Professor, Department of Medicine, New York University (NYU) Grossman School of Medicine; Medical Director, Thoracic Medical Oncology, NYU Langone Health’s Perlmutter Cancer Center. “These patient-reported outcomes showed that the patients who received treatment with zongertinib reported improvements in physical functioning and symptom burden. These findings build on previous clinical data to further support the use of zongertinib in the first-line setting for adult patients with HER2-mutant advanced NSCLC.” Advancing research with zongertinib data in HER2-positive colorectal, esophageal and breast cancers Early data to be presented highlights the potential of zongertinib in other HER2-driven cancers, including metastatic colorectal cancer (mCRC), metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEAC) and metastatic breast cancer (mBC). 2-4 These data will inform continued clinical development across multiple tumor types. These initial findings highlight the potential of zongertinib beyond lung cancer and support its continued research and development across multiple HER2-driven cancers. Exploring DLL3-directed therapy with obrixtamig in ES-SCLC Updated efficacy and safety results will also be presented from the ongoing Phase I DAREON ® ‑8 trial with obrixtamig, an investigational DLL3/CD3 T-cell engager, in combination with standard-of-care induction therapy (carboplatin, etoposide and atezolizumab) followed by maintenance obrixtamig plus atezolizumab in the first-line treatment of ES-SCLC (N=44), demonstrating encouraging efficacy.  5 “Given the longstanding need for innovative treatment options in small cell lung cancer, DLL3‑directed approaches such as obrixtamig represent an important area of ongoing research,” said Dr. Solange Peters, Professor and Director of Oncology, University Hospital of Lausanne, Switzerland. “In a disease where delivery of later lines of treatment is often not feasible and where urgent disease control is critical, these findings support continued investigation of obrixtamig in combination with standard-of-care therapy as initial treatment of extensive-stage small cell lung cancer.” Presentations at ASCO 2026 from Boehringer Ingelheim’s diverse oncology pipeline  r eflect its ambition to reshape cancer care: About HERNEXEOS® (zongertinib tablets)  HERNEXEOS (zongertinib tablets) is an irreversible tyrosine kinase inhibitor (TKI) that selectively inhibits HER2 while sparing wild-type EGFR, thereby minimizing associated toxicities. 7,8 HERNEXEOS is approved in the U.S., China, Hong Kong and Japan as the first orally administered targeted therapy for adult patients with HER2 ( ERBB2 )-mutant advanced non-small cell lung cancer. Zongertinib is not approved in other markets. The treatment is being evaluated in ongoing trials across a range of earlier stages and advanced solid tumors with HER2 alterations. Beamion LUNG-2 is an ongoing Phase III controlled study evaluating zongertinib as a first-line treatment for patients with advanced NSCLC that have HER2 tyrosine kinase domain mutations (NCT06151574). 9 Beamion LUNG-3 is a Phase III clinical trial investigating zongertinib as an adjuvant monotherapy in patients with early-stage, resectable NSCLC (Stage II-IIIB) with HER2 ( ERBB2 )-mutations (NCT07195695). 10 About obrixtamig Obrixtamig is an investigational novel Immunoglobin G (IgG)-like bispecific T-cell engager designed to bind concomitantly to DLL3 on tumor cells and CD3 on T-cells, potentially resulting in destruction of tumor cells by the body’s own immune system. 11  Obrixtamig is being evaluated in multiple, ongoing clinical trials, including a Phase I trial in combination with atezolizumab and chemotherapy in extensive-stage small-cell lung cancer (ES-SCLC) patients (DAREON ® -8), a Phase Ib study in combination with topotecan in patients with advanced SCLC (DAREON ® -9), and a Phase II trial in patients with relapsed/refractory DLL3-high extrapulmonary neuroendocrine carcinomas (epNEC) (DAREON ® -5). 5,12,13 Obrixtamig in combination with atezolizumab plus standard of care (SOC) chemotherapy is being evaluated as a first-line treatment vs. atezolizumab plus SOC chemotherapy in a Phase III trial for patients with ES-SCLC (DAREON ® -LUNG-1). 14 Additionally, a Phase III trial is ongoing to evaluate obrixtamig in combination with SOC chemotherapy vs. chemotherapy alone as first-line treatment in patients with DLL3-positive unresectable locally advanced or metastatic epNEC (DAREON ® -NEC-1). 15 About Boehringer Ingelheim in oncology We have a clear aspiration – to transform the lives of people facing cancer by delivering unprecedented impact, with the ultimate goal to redefine standards of care. Boehringer Ingelheim’s long-term commitment to scientific innovation is reflected by the company’s robust pipeline of cancer cell-directed and immuno-oncology investigational therapies, as well as in smart combinations of these approaches. In everything we do, we focus on people — not just data — working alongside them to develop solutions that truly meet their needs and help move cancer into the background of their lives. This drives our research approach, drawing on diverse minds and a long-term perspective to address the needs of people facing cancer today and for generations to come. Read more at  https://www.boehringer-ingelheim.com/human-health/cancer . About Boehringer Ingelheim Boehringer Ingelheim is a biopharmaceutical company active in both human and animal health. As one of the industry’s top investors in research and development, the company focuses on developing innovative therapies that can improve and extend lives in areas of high unmet medical need. Independent since its foundation in 1885, Boehringer takes a long-term perspective, embedding sustainability along the entire value chain. Our approximately 54,300 employees serve over 130 markets to build a healthier and more sustainable tomorrow. Learn more at  www.boehringer-ingelheim.com . References

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