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Block Listing Six Monthly Return

Avacta Group PLC has released its six-monthly block listing return. For the EMI scheme, the balance of unallotted securities from the previous return was 228,380, with 103,822 securities issued/allotted during the period, leaving a balance of 124,558 not yet issued. For the LTIP/ESOS scheme, the balance of unallotted securities was 1,546,375, increased by 6,500,000, with 6,862,713 securities issued/allotted during the period, resulting in a remaining balance of 1,183,662 not yet issued/allotted. Disclaimer*

Avacta Group PlcOctober 27, 20254
Block Listing Six Monthly Return

About this update from Avacta Group Plc

          Avacta Group plc   ("Avacta" or "the Group" or "the Company")   Block Listing Six Monthly Return   LONDON AND PHILADELPHIA  - October 27, 2025 Avacta Therapeutics (AIM: AVCT, 'the Company'), a clinical stage biopharmaceutical company developing pre|CISION ® ,  a tumor-activated oncology delivery platform, today makes the following notification pursuant to Schedule Six of the AIM Rules for Companies regarding its existing block admission arrangements:   Name of  applicant : Avacta Group plc Name of scheme: EMI scheme Period of return: From: 28 April 2025 27 October 2025 Balance of unallotted securities under scheme(s) from previous return: 228,380 Plus:      The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for): nil Less:      Number of  securities  issued/allotted under scheme(s) during period (see LR3.5.7G): 103,822 Equals:      Balance under scheme(s) not yet issued/allotted at end of period: 124,558   Name of  applicant : Avacta Group plc Name of scheme: LTIP/ESOS scheme Period of return: From: 28 April 2025 27 October 2025 Balance of unallotted securities under scheme(s): 1,546,375 Plus:      The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for): 6,500,000 Less:      Number of  securities  issued/allotted under scheme(s) during period (see LR3.5.7G): 6,862,713 Equals:      Balance under scheme(s) not yet issued/allotted at end of period: 1,183,662  Name of contact: Brian Hahn, Company Secretary Telephone number of contact: + 44 (0) 1904 217070   Ends-     For further information from Avacta Group plc, please contact:   Avacta Group plc Christina Coughlin, Chief Executive Officer https://avacta.com/ via ICR Healthcare Peel Hunt (Nomad and Joint Broker) James Steel / Chris Golden     www.peelhunt.com   Panmure Liberum (Joint Broker) Emma Earl / Will Goode / Mark Rogers   Zeus (Joint Broker) James Hornigold / George Duxberry Dominic King   www.panmureliberum.com     www.zeuscapital.co.uk   ICR Healthcare (Europe/UK media and investors) Mary-Jane Elliott / Jessica Hodgson / Stephanie Cuthbert [email protected]     Investor Contact Renee Leck THRUST Strategic Communications     [email protected]   Media Contact Carly Scaduto THRUST Strategic Communications   [email protected]     About pre|CISION ®   The key aspect of pre|CISION ® is its peptide drug conjugates (PDC) technology.  The combination of the cancer drug and the proprietary cleavable peptide (the PDC) is inert and incapable of entering cells and killing them until the peptide is specifically released within the tumor. The active payload in the pre|CISION ® PDC is released when the PDC comes into contact with the common tumor-associated protein, known as fibroblast activation protein (FAP), in the tumor. The release of the payload from the pre|CISION ® product directly in the tumor results in higher concentration of the drug at the tumor and lower blood and healthy tissue levels than standard systemic administration, offering the potential to improve efficacy and patient tolerability.   About Avacta -  www.avacta.com   Avacta is a clinical stage life sciences company developing an innovative proprietary drug delivery peptide drug conjugate (PDC) platform, pre|CISION ® . The pre|CISION ® platform uniquely enables the repurposing of a range of oncology drugs as PDC payloads with the goal to significantly reduce toxicity and side effects for patients by concentrating the drug directly in the tumor.  

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