Patients with restrictive lung disease demonstrate clinically meaningful benefit in FVC and improvements in multiple PROs for 5.0 mg/kg efzofitimod compared to placebo.
Company submitted protocol to FDA in June 2026 for planned Phase 3 study of efzofitimod in patients with chronic, symptomatic pulmonary sarcoidosis with restrictive lung disease.
SAN DIEGO, July 15, 2026 (GLOBE NEWSWIRE) -- aTyr Pharma, Inc. (Nasdaq: ATYR) ("aTyr" or the "Company"), a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced that the Company will present a subgroup analysis of the Phase 3 EFZO-FIT™ study of efzofitimod in pulmonary sarcoidosis, a major form of interstitial lung disease, at the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) 2026 Congress, which is scheduled to take place July 15 – 17, 2026, in Porto, Portugal.
"This subgroup analysis of patients from EFZO-FIT™ with restrictive lung disease presents clear evidence that those treated with efzofitimod experienced a clinically meaningful benefit in lung function and positive trends of improvement in multiple patient-reported outcomes (PROs) while removing steroids," said Sanjay S. Shukla, M.D., M.S., President and Chief Executive Officer of aTyr Pharma. "Following our recent interactions with the U.S. Food and Drug Administration (FDA), last month we submitted a protocol for a planned Phase 3 study in pulmonary sarcoidosis patients with restrictive lung disease (defined as forced vital capacity, or FVC, percent predicted ≤ 80% with a normal FEV1/FVC ratio), utilizing FVC as the primary endpoint of the study and the King's Sarcoidosis Questionnaire (KSQ)-Lung score as the key secondary endpoint. We believe the approach of investigating efzofitimod in this defined patient population where FVC is the relevant measure of lung function is a well-informed plan to demonstrate the potential for efzofitimod to improve the lives of these patients."
Details of the poster presentation appear below. The poster will be available on the aTyr website once presented.
Title: Evaluating Efzofitimod in a Subset of Sarcoidosis with the Restrictive Phenotype
Authors: Vis Niranjan, Pavithra Ramesh, Sanjay Shukla, Nelson Kinnersley, Daniel A. Culver. RxMD, aTyr Pharma, Octa Consulting Services, Cleveland Clinic.
Poster Number: PO123
Session: Controversies in Sarcoidosis Treatment and Disease Progression
Date and Time: Thursday, July 16, 2026, at 1:15pm WEST
Location: Porto, Portugal