AstraZeneca results: Q1 2026

About this update from Astrazeneca Plc

Strong revenue growth and positive readouts from high-value NMEs reinforce confidence in 2030 ambition CAMBRIDGE, England, April 29, 2026 --( BUSINESS WIRE )--AstraZeneca: Revenue and EPS summary Key performance elements for Q1 2026 (Growth numbers at constant exchange rates) Pascal Soriot, Chief Executive Officer, AstraZeneca, said: "We delivered strong growth in Q1 2026, with Total Revenue above $15 billion, demonstrating our consistent commercial execution. We are advancing through our catalyst‑rich period, with positive readouts for four high-value Phase III programmes since our last quarterly results, including first pivotal data for two key NMEs - tozorakimab in COPD and efzimfotase alfa in hypophosphatasia. We continue to invest in our commercial capabilities as we prepare for multiple launches, look forward to further readouts anticipated this year, and remain on track to achieve our ambition for 2030 and beyond." Guidance AstraZeneca reconfirms Total Revenue and Core EPS guidance 3 for FY 2026 at CER, based on the average foreign exchange rates through 2025. Total Revenue is expected to increase by a mid-to - high single-digit percentage Core EPS is expected to increase by a low double-digit percentage The Core Tax rate is expected to be between 18-22% If foreign exchange rates for April 2026 to December 2026 were to remain at the average rates seen in March 2026, it is anticipated that Total Revenue in FY 2026 would benefit from a low single-digit percentage positive impact (unchanged) compared to the performance at CER, and Core EPS growth would be broadly similar (unchanged) to the growth at CER. Results highlights Table 1: Milestones achieved since the prior results announcement Phase III and other registrational data readouts Regulatory approvals Regulatory submissions or acceptances* in major regions Other pipeline updates For recent trial starts and anticipated timings of key trial readouts, please refer to the Clinical Trials Appendix document in the financial results section of the AstraZeneca investor relations website: www.astrazeneca.com/investor-relations.html Table 2: Key elements of financial performance: Q1 2026 Corporate and business development Jacobio Pharma In March 2026, Jacobio Pharma announced that it had received an upfront payment of $100m from AstraZeneca. The payment was made in accordance with the collaboration and license agreement announced in December 2025 for JAB‑23E73, an investigational oral pan‑KRAS inhibitor. Pinetree In April 2026, AstraZeneca exercised its option to obtain an exclusive global license from Pinetree Therapeutics, Inc. (Pinetree) to develop and commercialize PTX-299, a first-in-class bispecific antibody degrader targeting EGFR. The option exercise triggers a $25m payment to Pinetree. Pinetree is also eligible to receive potential future development, regulatory, and commercial milestone payments and tiered royalties on global net sales if the product is successfully developed and commercialized. The total potential value of the agreement exceeds $500m. CSPC In April 2026, AstraZeneca closed the previously announced new strategic collaboration agreement with CSPC Pharmaceuticals to advance the development of multiple next-generation therapies for obesity and type 2 diabetes. AstraZeneca will pay an upfront payment of $1.2bn. See Note 5 for further details. Sustainability highlights The Company released its third Sustainability Impact Publication which includes its Sustainability achievements to date, updated 2030 Sustainability targets and case studies from across the enterprise on climate and nature action, health equity and health systems resilience. Reporting calendar The Company intends to publish its H1 and Q2 2026 results on 27 July 2026. Conference call A conference call and webcast for investors and analysts will begin today, 29 April 2026, at 14:30 UK time. Details can be accessed via astrazeneca.com . Reporting changes since FY 2025 The therapy area formerly referred to as ‘Vaccines and Immune Therapies’ is now titled ‘Infectious Disease’. The updated title aligns with the naming convention of AstraZeneca’s other therapy areas, which are named after the scientific fields in which they operate Notes To read AstraZeneca's Q1 2026 Financial Results press release in full, click here . View source version on businesswire.com: https://www.businesswire.com/news/home/20260428491257/en/ Contacts Global Media Relations team [email protected] +44 (0)1223 344 800

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