| Vertex Pharmaceuticals Incorporated | 1.48M | US$734M | 8.1% |
| Amgen Inc. | 1.96M | US$711M | 7.8% |
| Gilead Sciences, Inc. | 4.92M | US$622M | 6.8% |
| Regeneron Pharmaceuticals, Inc. | 715K | US$446M | 4.9% |
| Argenx Se | 368K | US$342M | 3.8% |
| Alnylam Pharmaceuticals, Inc. | 942K | US$284M | 3.1% |
| Natera, Inc. | 968K | US$263M | 2.9% |
| Revolution Medicines, Inc. | 1.35M | US$253M | 2.8% |
| Biogen Inc. | 1.04M | US$224M | 2.5% |
| Illumina, Inc. | 1.07M | US$188M | 2.1% |
| Moderna, Inc. | 2.57M | US$180M | 2.0% |
| Insmed Incorporated | 1.52M | US$162M | 1.8% |
| Beone Medicines Ltd. Class A | 564K | US$161M | 1.8% |
| Incyte Corporation | 1.4M | US$159M | 1.7% |
| United Therapeutics Corporation | 291K | US$158M | 1.7% |
| Roivant Sciences Ltd. | 3.66M | US$130M | 1.4% |
| Neurocrine Biosciences, Inc. | 700K | US$118M | 1.3% |
| Ascendis Pharma A/s | 438K | US$117M | 1.3% |
| Genmab A/s | 371K | US$102M | 1.1% |
| Exelixis, Inc. | 1.73M | US$93.9M | 1.0% |
| Ionis Pharmaceuticals, Inc. | 1.15M | US$91.1M | 1.0% |
| Bridgebio Pharma, Inc. | 1.2M | US$89.2M | 0.98% |
| Medpace Holdings, Inc. | 163K | US$86.3M | 0.95% |
| Madrigal Pharmaceuticals, Inc. | 154K | US$82.5M | 0.91% |
| Bio-techne Corp | 1.11M | US$78.1M | 0.86% |
| Biomarin Pharmaceutical Inc. | 1.35M | US$77.2M | 0.85% |
| Charles River Laboratories International, Inc. | 337K | US$76.5M | 0.84% |
| Arrowhead Pharmaceuticals, Inc. | 938K | US$76.4M | 0.84% |
| Axsome Therapeutics, Inc. | 305K | US$74.7M | 0.82% |
| Cytokinetics, Incorporated | 844K | US$71.9M | 0.79% |
| Krystal Biotech, Inc. | 182K | US$67.8M | 0.75% |
| Halozyme Therapeutics, Inc. | 832K | US$65.1M | 0.72% |
| Praxis Precision Medicines, Inc. | 185K | US$61.9M | 0.68% |
| Abivax Sa | 459K | US$61.1M | 0.67% |
| Alkermes Plc | 1.15M | US$60.5M | 0.67% |
| Vaxcyte, Inc. | 1M | US$58.2M | 0.64% |
| Kymera Therapeutics, Inc. | 504K | US$57.8M | 0.64% |
| Apogee Therapeutics, Inc. | 404K | US$53.6M | 0.59% |
| Protagonist Therapeutics, Inc. | 432K | US$53M | 0.58% |
| Rhythm Pharmaceuticals, Inc. | 470K | US$52.2M | 0.57% |
| Repligen Corporation | 378K | US$51.6M | 0.57% |
| Spyre Therapeutics, Inc. | 548K | US$48.6M | 0.54% |
| Bruker Corporation | 788K | US$47.4M | 0.52% |
| Ptc Therapeutics, Inc. | 568K | US$46.3M | 0.51% |
| Nuvalent, Inc. | 370K | US$45.7M | 0.50% |
| Twist Bioscience Corporation | 422K | US$43.4M | 0.48% |
| Tempus Ai, Inc. | 749K | US$43.4M | 0.48% |
| Mirum Pharmaceuticals, Inc. | 351K | US$41.1M | 0.45% |
| Cogent Biosciences, Inc. | 1.04M | US$40.3M | 0.44% |
| Xenon Pharmaceuticals Inc. | 643K | US$38.8M | 0.43% |
| Scholar Rock Holding Corporation | 684K | US$37.6M | 0.41% |
| Travere Therapeutics, Inc. | 640K | US$36.4M | 0.40% |
| Definium Therapeutics, Inc. | 743K | US$35M | 0.38% |
| Crispr Therapeutics Ag | 635K | US$34.6M | 0.38% |
| Oruka Therapeutics, Inc. | 359K | US$34.2M | 0.38% |
| Veracyte, Inc. | 551K | US$32.4M | 0.36% |
| 10x Genomics, Inc. | 799K | US$30.6M | 0.34% |
| Acadia Pharmaceuticals Inc. | 1.2M | US$30.3M | 0.33% |
| Cg Oncology, Inc. | 407K | US$28.9M | 0.32% |
| Denali Therapeutics Inc. | 1.05M | US$27.1M | 0.30% |
| Crinetics Pharmaceuticals, Inc. | 692K | US$25.9M | 0.29% |
| Erasca, Inc. | 1.33M | US$24.3M | 0.27% |
| Tango Therapeutics, Inc. | 751K | US$23.5M | 0.26% |
| Adaptive Biotechnologies Corporation | 1.09M | US$23.5M | 0.26% |
| Immunitybio, Inc. | 2.67M | US$23.3M | 0.26% |
| Beam Therapeutics Inc. | 664K | US$22.8M | 0.25% |
| Edgewise Therapeutics, Inc. | 556K | US$22.6M | 0.25% |
| Immunovant, Inc. | 574K | US$22.1M | 0.24% |
| Ideaya Biosciences, Inc. | 589K | US$21.9M | 0.24% |
| Ultragenyx Pharmaceutical Inc. | 635K | US$21.2M | 0.23% |
| Dyne Therapeutics, Inc. | 935K | US$20.8M | 0.23% |
| Arcutis Biotherapeutics, Inc. | 783K | US$20.5M | 0.23% |
| Newamsterdam Pharma Company N.v. | 566K | US$19.2M | 0.21% |
| Grail, Inc. | 281K | US$19.2M | 0.21% |
| Relay Therapeutics, Inc. | 1.02M | US$19M | 0.21% |
| Uniqure N.v. | 399K | US$18.4M | 0.20% |
| Arcus Biosciences, Inc. | 593K | US$18.3M | 0.20% |
| Tarsus Pharmaceuticals, Inc. | 286K | US$18M | 0.20% |
| Vera Therapeutics, Inc. | 414K | US$17.8M | 0.20% |
| Enliven Therapeutics, Inc. | 333K | US$16.9M | 0.19% |
| Nurix Therapeutics, Inc. | 695K | US$16.9M | 0.19% |
| Alumis Inc. | 594K | US$16.7M | 0.18% |
| Kodiak Sciences Inc | 410K | US$16M | 0.18% |
| Vericel Corporation | 358K | US$15.9M | 0.18% |
| Intellia Therapeutics, Inc. | 939K | US$15.9M | 0.17% |
| Caris Life Sciences, Inc. | 869K | US$15.5M | 0.17% |
| Biocryst Pharmaceuticals, Inc. | 1.53M | US$15.3M | 0.17% |
| Agios Pharmaceuticals, Inc. | 395K | US$14.7M | 0.16% |
| Disc Medicine, Inc. | 196K | US$14.4M | 0.16% |
| Summit Therapeutics Inc. | 956K | US$13.9M | 0.15% |
| Aurinia Pharmaceuticals Inc | 801K | US$13.6M | 0.15% |
| Adma Biologics Inc | 1.6M | US$13.4M | 0.15% |
| Biohaven Ltd. | 890K | US$13.2M | 0.15% |
| Zymeworks Inc. | 501K | US$13.1M | 0.14% |
| Anaptysbio, Inc. | 194K | US$13.1M | 0.14% |
| Abcellera Biologics Inc. | 1.66M | US$13M | 0.14% |
| Sarepta Therapeutics, Inc. | 719K | US$12.9M | 0.14% |
| Syndax Pharmaceuticals, Inc. | 572K | US$12.5M | 0.14% |
| Trevi Therapeutics, Inc. | 658K | US$12.3M | 0.14% |
| Recursion Pharmaceuticals, Inc. | 3.34M | US$12.2M | 0.13% |