RenovoRx, Inc. · NASDAQ:RNXT
RenovoRx — Technical Presentation (February 2025)
17 slides from RenovoRx's technical presentation, February 2025
Slide 1: Micro-CT Imaging Following Intra-Arterial Delivery of a Radiopaque Silicone Polymer Using a Double-Balloon Occlusion Catheter in Pigs
Micro-CT Imaging Following Intra-Arterial Delivery of a Radiopaque Silicone Polymer Using a Double-Balloon Occlusion Catheter in Pigs: A Model to Analyze Tissue Penetration via the Trans-Arterial Micro Perfusion (TAMP) Technique Paula Novelli, University of Pittsburgh Medical Center, Pittburgh, PA C
Slide 2: Avascular Tumors are Difficult to Treat Using Current Interventional Techniques: Pancreatic Tumors
Avascular Tumors are Difficult to Treat Using Current Interventional Techniques: Pancreatic Tumors Dense fibrotic stroma | Sparse tumor cellularity | Hypovascular tumors Liver tumors are vascularized Pancreatic tumors are hypovascular • Large tumor feeders – excellent targets for therapy • Inability
Slide 3: A Novel Solution: Trans-Arterial Micro-Perfusion (TAMP) via a Double-Balloon Catheter
A Novel Solution: Trans-Arterial Micro-Perfusion (TAMP) via a Double-Balloon Catheter with an Adjustable Occlusion Distance 3 NASDAQ | RNXT
Slide 4: Side Branch Exclusion Results in Increased Intravascular Pressure in the Isolated Vessel Segment During TAMP-Mediated Delivery
Side Branch Exclusion Results in Increased Intravascular Pressure in the Isolated Vessel Segment During TAMP-Mediated Delivery • RenovoCath®’s slidable balloons allow for catheter positioning with side branch exclusion • The resulting increase in intravascular pressure upon infusion is a requisite f
Slide 5: Involvement of the Vasa Vasorum in TAMP-Mediated Transmural Delivery
Involvement of the Vasa Vasorum in TAMP-Mediated Transmural Delivery • Following TAMP-mediated methylene blue delivery, dye was observed in vasa vasorum externa vessels of the adventitia (panel a) • Following TAMP-mediated delivery of gold nanoparticles, particles were observed via transmission elec
Slide 6: Defining the Microvasculature Reached During Trans-Arterial Micro Perfusion via Micro-CT Imaging
Defining the Microvasculature Reached During Trans-Arterial Micro Perfusion via Micro-CT Imaging • Micro-CT imaging was utilized as a more quantitative method to evaluate the microvasculature involved in TAMP-mediated delivery • A non-surviving porcine model was established for TAMP-mediated deliver
Slide 7: Microfil Delivery via TAMP in Porcine Splenic Arteries
Microfil® Delivery via TAMP in Porcine Splenic Arteries Scout angiography Following Microfil® injection C A) Still angiogram of single actuated RenovoCath® confirming position in the splenic artery B) Terminal angiography at the time of Microfil® injection C) Gross image (dorsal view) of the harvest
Slide 8: Micro-CT Imaging Showing Penetration of Microfil
Micro-CT Imaging Showing Penetration of Microfil® 3D reconstruction based on X-ray micro-CT with Microfil® contrast agent marked in blue 8 NASDAQ | RNXT
Slide 9: Micro-CT Imaging Showed Extensive Penetration of Microfil into the Surrounding Microvasculature and Tissue
Micro-CT Imaging Showed Extensive Penetration of Microfil® into the Surrounding Microvasculature and Venous, Lymphatic, and Parenchymal Splenic Tissue A B C 3D reconstructions based on X-ray micro-CT with Microfil® contrast agent marked in blue: A) 3D rendered micro-CT image of splenic artery withou
Slide 10: Histological Analysis Following TAMP-Delivered Microfil Showed Extensive Filling of Microvessels
Histological Analysis Following TAMP-Delivered Microfil® Showed Extensive Filling of Microvessels within Perivascular Tissues Artery a Artery b c Artery Vein Vein Vein Serial histologic sections of porcine splenic artery following TAMP-mediated delivery of Microfil® contrast agent: A), B), C) Low po
Slide 11: The Therapeutic Benefit of TAMP-Mediated Chemotherapy Delivery is Enhanced with Prior Radiation
The Therapeutic Benefit of TAMP-Mediated Chemotherapy Delivery is Enhanced with Prior Radiation RR1 + RR2 Combined Data* Hypothesis for mechanism of action: Prior radiation reduces (n=35 patients with stage III LAPC) venous outflow by decreasing the microvasculature, thereby enhancing TAMP-mediated
Slide 12: Investigating the Mechanism by which Prior Radiation Enhances TAMP's Therapeutic Benefit: SBRT + TAMP
Investigating the Mechanism by which Prior Radiation Enhances TAMP’s Therapeutic Benefit: SBRT + TAMP Micro-CT Porcine Study Question: Does prior radiation enhance tissue penetration by TAMP? Methods: ➢ For each of 3 pigs, the left kidney received one session of SBRT at 15 Gys and the right kidney w
Slide 13: Microfil Delivery via TAMP With and Without Prior SBRT
Microfil® Delivery via TAMP With and Without Prior SBRT 1 month later, simultaneous Left kidney received SBRT (15 Gys); Right kidney untreated Microfil® delivery via TAMP 13 NASDAQ | RNXT
Slide 14: Micro-CT Imaging of TAMP-Mediated Microfil Penetration With and Without Prior SBRT
Micro-CT Imaging of TAMP-Mediated Microfil® Penetration With (Left Kidney) and Without (Right Kidney) Prior SBRT 14 NASDAQ | RNXT
Slide 15: Micro-CT Imaging Showed Delayed Microfil Washout With Prior SBRT vs Without
Micro-CT Imaging Showed Delayed Microfil® Washout With Prior SBRT vs Without Right kidney Left kidney (no SBRT) (SBRT prior to TAMP) 3D reconstructions based on micro-CT: metal and stain 15 NASDAQ | RNXT
Slide 16: Conclusions
Conclusions • A non-surviving porcine model was established for micro-CT imaging following TAMP-mediated delivery of Microfil® silicone-based contrast agent • Following TAMP-mediated delivery to porcine splenic arteries, micro-CT imaging showed extensive penetration of Microfil® into the surrounding
Slide 17: Questions & Discussion
Questions & Discussion 17 Drug infused Locally NASDAQ | RNXT Confidential – Do not distribute