Anteris Technologies Global Corp. · NASDAQ:AVR
Anteris Technologies Global — PCR London Valves 2025
16 slides from Anteris Technologies Global's conference presentation, Nov 18, 2025
Slide 1: Aortic Valve Area Reduction: Novel Concept to Quantify AS Severity
Aortic Valve Area Reduction: Novel Concept to Quantify AS Severity Miho Fukui, Maurice Enriquez-Sarano, Rebecca T. Hahn, Evan Walser-Kuntz, Atsushi Okada, Mohammed N. Abed, Larrissa I. Stanberry, Martin B. Leon and Vinayak N. Bapat
Slide 2: Potential conflicts of interest
Potential conflicts of interest Speaker's name: Miho Fukui ☑ I have the following potential conflicts of interest to report • Receipt of honoraria or consultation fees - Edwards Lifesciences • Receipt of honoraria or consultation fees - Medtronic • Receipt of honoraria or consultation fees - Anteris
Slide 3: Is AVA < 1cm2 Cutoff Appropriate for Everyone?
Is AVA < 1cm2 Cutoff Appropriate for Everyone? AVA (cm2) ? They may have different ? original AVA ? 1.0 Healthy baseline Severe AS Time pcrlondonvalves.com
Slide 4: What If We Knew the Original Healthy AVA?
What If We Knew the Original Healthy AVA? AVA (cm2) 5.0 % AVA reduction = (AVAnormal – AVAAS) X 100 80% 4.0 AVAnormal 3.0 70% 2.0 60% 1.0 Healthy baseline Severe AS Time pcrlondonvalves.com
Slide 5: Treating Some Patients Too Late?
Treating Some Patients Too Late? AVA (cm2) Larger 5.0 % AVA Reduction 80% 4.0 3.0 70% 2.0 More cardiac 60% damage? 1.0 Healthy baseline Severe AS Time pcrlondonvalves.com
Slide 6: What Is the Original Healthy AVA?
What Is the Original Healthy AVA? AVA (cm2) ? What is their normal AVA? ? ? 1.0 Healthy baseline Severe AS Time pcrlondonvalves.com
Slide 7: Normal AVA can be estimated by Annulus Area
Normal AVA can be estimated by Annulus Area 800 <Systolic> AVAnormal = 56 +172 x BSA 800 AVAnormal =7.5+0.80 x Annulus Area R²=0.249 2D TEE-AVA (mm2) 600 2D TEE-AVA (mm2) 600 R²=0.907 400 400 200 200 N=347 0 0 0 200 400 600 800 1.5 2.0 2.5 3.0 CT-Systolic Annulus Area (mm2) Body surface Area (m ) 2
Slide 8: Study Aim
Study Aim • Calculate personalized % AVA reduction at the time of TAVI • Study if the % AVA reduction is meaningful beyond conventional echo parameters pcrlondonvalves.com
Slide 9: Study cohort of TAVR to assess impact of %AVA reduction
Study cohort of TAVR to assess impact of %AVA reduction TAVR @ Abbott Northwestern Hospital Jul 2015 – Dec 2021 1. AVAnormal = 7.5+0.795 x AAsystolic N=1471 Pre-TAVR CT Exclusion • Bicuspid • Valve-in-Valve • Previous aortic valve repair • No pre-TAVR CT performed 2. AVA reduction (%) Study populati
Slide 10: Wide Variability in %AVA Reduction
Wide Variability in %AVA Reduction Medium 80% %AVA Reduction Tertile 78% 82% Lower Middle Greater Reduction Reduction Reduction (<78%) (78-82%) (> 82%) 90 %AVA reduction pre-TAVR (%) 150 80 100 Count 2nd/3rd tertile: 82.48% 1st/2nd tertile: 77.88% 70 median: 80.26% 50 60 y=97-22.1x R²=0.552 0 50 50
Slide 11: Patient characteristics
Patient characteristics AVA reduction AVA reduction AVA reduction Overall, < 77.9% 77.9 – 82.5% >82.5% p N = 1,212 N = 404 N = 404 N = 404 Age (years) 82 (76, 87) 80 (74, 86) 83 (77, 87) 82 (77, 87) <0.001 Male, n (%) 705 (58%) 182 (45%) 239 (59%) 284 (70%) <0.001 DM, n (%) 422 (35%) 144 (36%) 140 (
Slide 12: Greater AVA reduction, More Cardiac Damage
Greater AVA reduction, More Cardiac Damage AVA reduction AVA reduction AVA reduction Overall, Pre-TAVR TTE N = 1,212 < 77.9% 77.9 – 82.5% >82.5% p N = 404 N = 404 N = 404 LVEF (%) 60 (53, 65) 63 (58, 68) 60 (55, 65) 58 (45, 63) <0.001 LV mass index (g/m2) 113 (94, 136) 105 (88, 127) 117 (96, 140) 12
Slide 13: Better Detection of Advanced AS with AVA reduction
Better Detection of Advanced AS with AVA reduction Estimated risk of advanced cardiac Incremental value of AVA reduction damage (≧Stage 3) at pre-TAVR Baseline model includes age, sex, history of CAD and Afib, along with AVA, MG and peak V pcrlondonvalves.com
Slide 14: The essentials to remember
The essentials to remember • %AVA reduction introduced as a novel, personalized metric for AS severity • This metric improves the quantification of AS severity and risk stratification • May help optimize timing of aortic valve intervention pcrlondonvalves.com
Slide 15: Fukui-Sarano-Bapat Definition
Fukui-Sarano-Bapat Definition Current definition New definition by AVA reduction Aortic annulus area (cm2) Aortic annulus area (cm2) / diameter pcrlondonvalves.com
Slide 16: pcronline.com
pcronline.com