New Prospective, Multicenter Study Presented at SMR Demonstrates Castle Biosciences’ DecisionDx®-Melanoma Test Provides Significant Risk Prediction for Patients with Cutaneous Melanoma, Adding Value to Current Stage-Based Treatment Pathway Decisions

FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it will present new data related to its DecisionDx-Melanoma and DecisionDx®-UM tests for patients with cutaneous melanoma (CM) and uveal melanoma (UM), respectively, at the 21st International Congress of the Society for Melanoma Research (SMR), taking place Oct. 10-13, 2024, in New Orleans.

“In large prospective and retrospective studies, our DecisionDx-Melanoma test has been shown to provide clinical value above and beyond current staging paradigms and other tests currently available for patients with cutaneous melanoma,” said Derek Maetzold, president and chief executive officer of Castle Biosciences. “Clinical use studies have shown that clinicians act upon these results to improve risk-aligned treatment pathway decisions which are associated with improved outcomes.”

Details regarding Castle’s posters at SMR are included below. Posters will be available for viewing starting the evening of Thursday, Oct. 10, through the evening of Saturday, Oct. 12.

DecisionDx-Melanoma

• Poster title: In a prospective, multicenter study, the 31-GEP identified patients at increased risk of tumor recurrence and added significant prognostic value to AJCC staging
• Poster #: 40
• Summary: This study included 876 patients with Stage I-III CM from multiple centers who received DecisionDx-Melanoma testing as part of their clinical care. The data show DecisionDx-Melanoma stratified patients by their risk of recurrence and was a significant predictor of recurrence; patients with Class 1A (lowest risk) test results had significantly higher three-year recurrence-free survival than those with a Class 1B/2A (increased risk) or Class 2B (highest risk) test result (p