Data Presentations at 2023 Winter Clinical Dermatology Conference - Hawaii® Support Clinical Value of Castle Biosciences’ Skin Cancer Test Portfolio

Real-world data from Castle’s collaboration with the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) program registries confirm ability of DecisionDx®-Melanoma to identify patients with high-risk tumor biology in a cohort of patients with a negative lymph node

New clinician-developed real-world algorithm provides a framework to incorporate DecisionDx®-SCC test results into clinical practice within established guidelines

Survey of dermatologists shows that diagnostic GEP test results from MyPath® Melanoma and DiffDx®-Melanoma can aid in making personalized and appropriate patient management decisions

FRIENDSWOOD, Texas--(BUSINESS WIRE)-- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that new data supporting the clinical value of the Company’s skin cancer test portfolio is being shared in poster presentations at the 2023 Winter Clinical Dermatology Conference - Hawaii®, being held Jan. 13-18 in Kohala Coast, Hawaii.

“At Castle, we are committed to challenging the status quo to improve disease management through deep scientific expertise, unique value insight and strong data development,” said Derek Maetzold, president and chief executive officer of Castle Biosciences. “The data that we are presenting at the 2023 Winter Clinical Dermatology Conference – Hawaii demonstrates the ability of our tests to help guide personalized and risk-aligned patient management decisions with a goal of enabling better patient outcomes.”

The posters below will be displayed for viewing in the Grande Ballroom Salon III for the duration of the conference.

DecisionDx®-Melanoma

Poster title: Improved prognostic guidance by the 31-gene expression profile test for clinical decisions after a negative lymph node for patients with cutaneous melanoma

This study evaluated the ability of the DecisionDx-Melanoma test to identify patients with high-risk tumor biology in an unselected, clinically tested cohort of patients in the SEER registries with negative lymph nodes (LN) (n=3,271). Patients with low-risk (Class 1A) test results had higher three-year melanoma-specific survival (MSS) than patients with a high-risk (Class 2B) result (Class 1A: 99.7% vs. Class 2B: 91.8%, p