Adaptive Biotechnologies Announces New Data at the 66th ASH Annual Meeting Highlighting Advances in MRD Testing with clonoSEQ® and Its Impact on Blood Cancer Treatment Decisions

New data demonstrate the actionability of clonoSEQ for tailoring treatment decisions in patients with MCL, CLL, MM and ALL

Studies show depth of response at 10-6 provides more accurate assessment of treatment responses

SEATTLE, Dec. 07, 2024 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (Nasdaq: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced new data demonstrating the impact of measurable residual disease (MRD) assessment using Adaptive’s next-generation sequencing-based clonoSEQ® test in blood cancer clinical care and drug development. The data are featured in more than 65 abstracts being presented at the 66th Annual Meeting of the American Society of Hematology (ASH), taking place December 6-10 in San Diego.

“At this year's ASH meeting, we're proud to see clonoSEQ's pivotal role in shaping the future of blood cancer care,” said Susan Bobulsky, chief commercial officer, MRD, Adaptive Biotechnologies. “The breadth of data presented highlight the growing recognition of clonoSEQ as a powerful tool for accelerating patient access to novel therapies, optimizing clinical care and delivering actionable insights that improve outcomes for patients living with a variety of blood cancers."

Phase 3 data from the ECOG-ACRIN EA4151 trial indicate that autologous hematopoietic cell transplantation (auto-HCT) may not provide additional benefit for mantle cell lymphoma (MCL) patients in first complete remission (CR) who have undetectable minimal residual disease (uMRD) at a sensitivity of 10⁻⁶. The findings will be presented in a late-breaking abstract titled, Lack of Benefit of Autologous Hematopoietic Cell Transplantation (auto-HCT) in Mantle Cell Lymphoma (MCL) Patients (pts) in First Complete Remission (CR) with Undetectable Minimal Residual Disease (uMRD): Initial Report from the ECOG-ACRIN EA4151 Phase 3 Randomized Trial (Abstract LBA6). Patients in CR with uMRD at 10⁻⁶ sensitivity from peripheral blood were randomized to receive either auto-HCT plus three years of maintenance rituximab (MR) or MR alone. Interim analysis, with a median follow-up of 2.7 years, showed no significant difference in overall survival (OS) between the two groups, suggesting that auto-HCT may be unnecessary for patients achieving deep remission as measured by highly sensitive MRD assessment.

“Our study indicates that highly sensitive MRD testing, such as the clonoSEQ assay that we used, can potentially be used to tailor treatment decisions for patients with MCL,” said Timothy Fenske, M.D., professor, department of medicine, Medical College of Wisconsin. “By identifying patients in first complete remission who also have undetectable MRD status at 10⁻⁶, we can potentially avoid the need for autologous hematopoietic cell transplantation, sparing them the associated risks and burdens. At the same time, patients who remain MRD-positive post-induction may benefit from more intensive consolidation therapy such as auto-HCT to optimize their outcomes.”

Data from the FELIX study indicate that achieving deep molecular remission, defined as MRD levels below 10⁻⁶, correlates with improved outcomes in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) treated with obecabtagene autoleucel. These findings were presented in an oral session titled Obecabtagene autoleucel (obe-cel) for Adult Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (R/R B-ALL): Deep Molecular Remission May Predict Better Outcomes (Abstract 963). The study found that 84% of treatment responders who had a clonoSEQ MRD test, achieved MRD