| Crinetics Pharmaceuticals, Inc. | 39,373 | US$3.29M | 3.3% |
| Kiniksa Pharmaceuticals International, Plc | 26,155 | US$1.94M | 2.0% |
| Verastem, Inc. | 331K | US$1.92M | 1.9% |
| Precigen, Inc. | 305K | US$1.91M | 1.9% |
| Omeros Corporation | 155K | US$1.84M | 1.9% |
| Nuvation Bio Inc. | 276K | US$1.75M | 1.8% |
| Regeneron Pharmaceuticals, Inc. | 2,218 | US$1.69M | 1.7% |
| Protagonist Therapeutics, Inc. | 12,363 | US$1.69M | 1.7% |
| Acadia Pharmaceuticals Inc. | 64,350 | US$1.66M | 1.7% |
| Bridgebio Pharma, Inc. | 20,315 | US$1.63M | 1.7% |
| Beone Medicines Ltd. Class A | 5,132 | US$1.62M | 1.6% |
| Xeris Biopharma Holdings, Inc. | 200K | US$1.61M | 1.6% |
| Halozyme Therapeutics, Inc. | 19,528 | US$1.61M | 1.6% |
| Liquidia Corporation | 19,053 | US$1.6M | 1.6% |
| Ironwood Pharmaceuticals, Inc. | 372K | US$1.57M | 1.6% |
| Arrowhead Pharmaceuticals, Inc. | 18,212 | US$1.54M | 1.6% |
| Roivant Sciences Ltd. | 45,179 | US$1.53M | 1.6% |
| Ligand Pharmaceuticals Incorporated | 5,310 | US$1.53M | 1.5% |
| Rhythm Pharmaceuticals, Inc. | 15,357 | US$1.52M | 1.5% |
| Geron Corporation | 1.18M | US$1.52M | 1.5% |
| Rigel Pharmaceuticals, Inc. | 41,313 | US$1.52M | 1.5% |
| Ascendis Pharma A/s | 6,224 | US$1.52M | 1.5% |
| Arcutis Biotherapeutics, Inc. | 55,666 | US$1.5M | 1.5% |
| Incyte Corporation | 12,506 | US$1.49M | 1.5% |
| Cytokinetics, Incorporated | 19,346 | US$1.49M | 1.5% |
| Moderna, Inc. | 27,191 | US$1.49M | 1.5% |
| Amgen Inc. | 3,820 | US$1.47M | 1.5% |
| Travere Therapeutics, Inc. | 26,078 | US$1.46M | 1.5% |
| Krystal Biotech, Inc. | 4,269 | US$1.46M | 1.5% |
| Vertex Pharmaceuticals Incorporated | 3,052 | US$1.46M | 1.5% |
| Biomarin Pharmaceutical Inc. | 24,255 | US$1.46M | 1.5% |
| Zai Lab Ltd. | 797K | US$1.45M | 1.5% |
| Mirum Pharmaceuticals, Inc. | 13,661 | US$1.45M | 1.5% |
| Denali Therapeutics Inc. | 62,658 | US$1.44M | 1.5% |
| Tg Therapeutics, Inc. | 27,407 | US$1.43M | 1.4% |
| Neurocrine Biosciences, Inc. | 8,494 | US$1.42M | 1.4% |
| Syndax Pharmaceuticals, Inc. | 74,364 | US$1.42M | 1.4% |
| Gilead Sciences, Inc. | 10,807 | US$1.41M | 1.4% |
| Biocryst Pharmaceuticals, Inc. | 156K | US$1.4M | 1.4% |
| Adma Biologics Inc | 165K | US$1.4M | 1.4% |
| Ultragenyx Pharmaceutical Inc. | 55,734 | US$1.39M | 1.4% |
| Harmony Biosciences Holdings, Inc. | 39,383 | US$1.39M | 1.4% |
| Agios Pharmaceuticals, Inc. | 46,067 | US$1.38M | 1.4% |
| Biogen Inc. | 6,785 | US$1.38M | 1.4% |
| Theravance Biopharma, Inc. | 81,560 | US$1.38M | 1.4% |
| Immunitybio, Inc. | 191K | US$1.37M | 1.4% |
| Insmed Incorporated | 13,870 | US$1.37M | 1.4% |
| Exelixis, Inc. | 25,544 | US$1.35M | 1.4% |
| Iovance Biotherapeutics, Inc. | 333K | US$1.35M | 1.4% |
| Kura Oncology, Inc. | 150K | US$1.35M | 1.4% |
| Madrigal Pharmaceuticals, Inc. | 2,824 | US$1.32M | 1.3% |
| Sarepta Therapeutics, Inc. | 88,646 | US$1.32M | 1.3% |
| Crispr Therapeutics Ag | 27,251 | US$1.31M | 1.3% |
| Zymeworks Inc. | 59,315 | US$1.3M | 1.3% |
| Tarsus Pharmaceuticals, Inc. | 21,906 | US$1.29M | 1.3% |
| United Therapeutics Corporation | 2,487 | US$1.29M | 1.3% |
| Aurinia Pharmaceuticals Inc | 85,786 | US$1.28M | 1.3% |
| Ptc Therapeutics, Inc. | 18,062 | US$1.23M | 1.2% |
| Ardelyx, Inc. | 239K | US$1.18M | 1.2% |
| Axsome Therapeutics, Inc. | 5,319 | US$1.16M | 1.2% |
| Phathom Pharmaceuticals, Inc. | 131K | US$1.15M | 1.2% |
| Novavax, Inc. | 153K | US$1.12M | 1.1% |
| Alnylam Pharmaceuticals, Inc. | 4,798 | US$986K | 1.0% |
| Ionis Pharmaceuticals, Inc. | 18,522 | US$959K | 0.97% |
| Kalvista Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Esperion Therapeutics, Inc. | 0 | US$0 | 0.00% |
| Apellis Pharmaceuticals, Inc. | 0 | US$0 | 0.00% |
| Lenz Therapeutics, Inc. | 0 | US$0 | 0.00% |