CV Sciences, Inc. · OTC:CVSI
CV Sciences — Corporate Update (August 2018)
45 slides from CV Sciences's corporate update, Aug 7, 2018
Slide 1: Cannabidiol (CBD) Therapeutic Uses for Health and Wellness
Cannabidiol (CBD) Therapeutic Uses for Health and Wellness Joseph C. Maroon, M.D. Board - Certified Neurosurgeon Sports Medicine Consultant Health and Nutrition Expert Aug 4, 2018
Slide 2: What Does Healthy Mean to You?
WHAT bOES HEALTHY MEAN TO YOu? a “a
Slide 3: To be Healthy
To be Healthy Being physically healthy and fit involves not only how you look, but also how you feel and your overall health. Healthy Factors: 1. Physical 2. Nutritional 3. Toxin Free 4. Spiritual/ Emotional
Slide 4: Oxidative Stress, Cancer, Heart Disease, Alzheimer's Disease, etc.
Oxidative Stress, Cancer, Heart Disease, Alzheimer's Disease, etc.
Slide 5: Epigenetics and Gene Activation
Epigenetics and Gene Activation For Health and Longevity Signaling oO molecules Exercise * BDNF Ce) . * Endurance 3 bs Environment Strength and Flexibilit Clean air, water is ety g Ds ot yt and soil ° f ; *No smoking ° Transcription factors = . ° Nutritional Factors < fs * Calorie Restriction e SNe
Slide 6: CBD as Both a Dietary Supplement and Pharmaceutical
CBD as Both a Dietary Supplement and Pharmaceutical Differences Drug – Requires Prescription • FDA clearance, Drug Quality and Quantity Testing Required, Medical/Therapeutic Claim to Treat Something, possible higher dose than supplement Dietary Supplement – NO Prescription • NO FDA clearance, Food Q
Slide 7: Best Example of Supplement and Prescription Drug using Same Product
Best Example of Supplement and Prescription Drug using Same Product Omega - 3 Fish Oil • Supplements – 1.07 to 1.15B US annual sales, Global ~3.3 B • Pharmaceutical • Lovaza (GlaxoSmithKline) • Generic versions of Lovaza • Omtryg ( Trygg Pharma, Inc.) • Epanova (AstraZeneca Pharmaceuticals LP). • Va
Slide 8: FDA Approves First CBD Drug
FDA Approves First CBD Drug Reuters U.S. approves first marijuana plant - derived drug June 25, 2018 The U.S. Food and Drug Administration approved GW Pharmaceuticals epilepsy treatment on Monday, making it the first cannabis - based drug to win approval in the country . The landmark approval could
Slide 9: What Does this Mean?
What Does this Mean? • Requires FDA to rule on whether to change CBD Schedule Classification from Schedule I • Will require public release of Safety Data from GW Pharma Animal and Human Trials • Resultant Effects: • Will unlikely need to complete expensive and time consuming safety trials for CBD •
Slide 10: CBD no longer a banned substance for international sport
• CBD will no longer be listed as a banned substance for international sport competition for 2018 • Δ9 - THC will still be prohibited • CBD extracted from the hemp plant has than 0.3% Δ9 - THC. SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2018 PROHIBITED LIST, World Anti - Doping Agency, htt
Slide 11: Food Should Be Our Medicine
FOOD SHOULD = OUR MEDICINE OUR MEDICINE «
Slide 12: Case Report – Pain Reduction
Case Report – Pain Reduction
Slide 13: CRN 2017 Annual Survey Dietary Supplements
https://www.crnusa.org/resources/crn - 2017 - annual - survey - dietary - supplements 2017
Slide 14: Cannabis sativa: Marijuana vs Hemp
Cannabis, genus Cannabis sativa , species Marijuana Cultivated to have maximum (5 to 20%) psychoactive THC Hemp Significantly more Cannabidiol (CBD) No Cognitive side effects THC (< 0.3%) Trends in new crops and new uses. 2002. J. Janick and A. Whipkey (eds.). ASHS Press, Alexandria, VA. Hemp: A New
Slide 15: Plant-based Medical Marijuana
Plant - based Medical Marijuana (Whole Plant and Extracts THC, CBD, Terpenes) cannabis sativa – Selectively Cultivated Commercially to have Higher Levels of THC Indications: (selected List) • Intractable headaches • Cancer pain • Nerve pain • Muscle spasms/spasticity • Glaucoma • Nausea from cancer
Slide 16: Phytocannabinoids found in Marijuana and Hemp
There are over 60 Phytocannabinoids found in Marijuana and Hemp with a Wide Variety of Actions
Slide 17: Human health benefits of Hemp Cannabidiol
Human health benefits: • Anti - inflammation - Decreased Cytokine and chemokine actions • Analgesic Effects • Anxiolytic • Neuroprotective Hemp Cannabidiol (CBD) Schurman LD, Lichtman AH., Endocannabinoids: A Promising Impact for Traumatic Brain Injury. Front Pharmacol . 2017 Feb 17;8:69. doi : 10.3
Slide 18: Temp - A.ppt 8/7/2018
Temp - A.ppt 8/7/2018 18 18
Slide 19: Endocannabinoid System
Endocannabinoid System Acts via the Endogenously Produced Endocannabinoids (on demand neuromodulators) • Anandamide ( AEA ) • 2 - Acylglycerol (2 - AG)
Slide 20: Endocannabinoid System: CB1 and CB2 Receptors
Endocannabinoid System CB1 Receptor (THC) ▪ Central and Peripheral Nervous System ▪ Distributed throughout the brain: ▪ Pleasure ▪ Memory ▪ Thought ▪ Concentration ▪ Sensory and time perceptions ▪ Coordinated movement ▪ Sparsely found in the cardiopulmonary centers in the brainstem CB2 Receptor (CBD
Slide 21: Case Reports: Failed Traditional Tx
Case Reports: Failed Traditional Tx On Feb 23, 2018, Dr. Maroon, Overall, I am extremely happy with the results of this supplement. …. able to sleep easily and soundly through out the night and my anxiety has been reduce tremendously. Post - concussion syndrome I believe it truly makes a huge differ
Slide 22: Medical Cannabis Users Reporting Use for Each Condition
Table 2. Total Number and Percentages of Medical Cannabis Users Reporting Use for Each Medical Condition Pain 874 (61.2) Anxiety 830 (58.1) Depression 719 (50.3) Headache/migraine 507 (35.5) Other 488 (34.1) Nausea 392 (27.4) Muscle spasticity 263 (18.4) Arthritis 245 (17.1) Irritable bowel 211 (14.
Slide 23: THC and CBD exert opposite actions on brain function
THC and CBD exert opposite actions on brain function and psychopathology. CBD reduces the effects of THC on several behavioral functions including reduced anxiety and improve the sensation of wellbeing
Slide 24: CBD Reduces Anxiety, THC Increases Anxiety
CBD – Reduces Anxiety THC – Increases Anxiety
Slide 25: CBD & Wellness Universal Truths
CBD & Wellness Universal Truths Common link for almost all ‘ unwell’ conditions, i.e., pain, chronic disease and addiction? • Anxiety / Depression / Stress • Loss of Control • Loss of Resilience • Pain – Mental /Physical
Slide 26: CBD & Wellness Universal Truths: People Feel Better
CBD & Wellness Universal Truths People Feel Better When Taking CBD • Improved Mood/Outlook • Clearer Thinking • And Resilience
Slide 27: Resilience
re·sil·ience noun 1. the capacity to recover quickly from difficulties; toughness Resilience Keys to Happiness, Wellness and Coping with Pain and Disease
Slide 28: The Many Faces of Anxiety
THE MANY FACES OF ANXIETY 40 MILLION Americans age 18 and older are affected by anxiety disorders. 6.8 MILLION adults are affected by Generalized Anxiety Disorder (GAD) — women twice as much as men. 15 MILLION adult men and women are affected by Social Anxiety Disorder. The symptoms usually start at
Slide 29: Anxiety – Leading Cause of Addiction
Alcohol Tobacco Food Opiates Internet Leading to Self - Medication In US 36 million Have Reported Untreated Anxiety Anxiety – Leading Cause of Addiction
Slide 30: Drug overdose deaths estimated in 2016
64,000 drug overdose deaths estimated in 2016
Slide 31: Percentage taking antidepressants
~16% of Ages 40 - 59 Take Antidepressants
Slide 32: Link Between Smoking and Mental Health Conditions
What Is the Link Between Smoking and Mental Health Conditions? • Smoking is much more common among adults with depression and anxiety, than in the general population • About 3 in 10 cigarettes smoked by adults in the United States are smoked by persons with mental health conditions
Slide 33: Smoking Epidemic – Fear of Withdrawal
Smoking Epidemic – Fear of Withdrawal • Nicotine withdrawal is the primary addictive driver of cigarette smoking • Withdrawal includes: • physiological symptoms (headaches, nausea) • Affective symptoms (anxiety, depression and irritability ) • Impaired cognitive performance (delay discounting, respo
Slide 34: How Can CBD Alter Addiction?
How Can CBD Alter Addiction? • The “Pleasure Centers” of the brain reinforce the effects of drugs and the prolonged risk of relapse • The endocannabinoid system (ECS) influences the acquisition and maintenance of drug - seeking behaviors • CBD modulated the ECS and thereby alters addictive cravings
Slide 35: Mechanisms
Mechanisms CBD inhibits the reuptake Anandamide and explains some of its effectiveness in withdrawal syndrome and addictive processes CBD’s effect on serotoninergic receptors may be highly relevant in drug reward and stress vulnerability Antianxiety properties of CBD mitigate withdrawal symptoms Pai
Slide 36: Human Addiction Studies
Human Addiction Studies CBD on tobacco - related addictive behaviors Design - randomized, double - blind, placebo - controlled 24 smokers, 2 groups CBD inhaler (400 µg/inhalation) vs. a placebo inhaler . Told to use the inhaler whenever they felt the urge to smoke for 1 wk Monitored - daily cigarett
Slide 37: Pain: Largest U.S. Public Health Crisis
Pain: Largest U.S. Public Health Crisis Prevalence 1 00M: Persistent Pain Annual Healthcare & Productivity Cost: $660-630 Billion 80M2 ~) Cardiovascular Disease ot Annual Healthcare & Productivity 328 Million Cost: $309 Billion’ Prescriptions and $13 Billion 29M? Cancer (v) Annual Healthcare & Produ
Slide 38: Scope of and Evidence for use in Chronic Pain and Addiction
Scope of and Evidence for use in Chronic Pain and Addiction https://newfrontierdata.com/wp - content/uploads/2015/11/CIAR_Webinar_FINAL.pdf
Slide 39: CBD and Opiates
CBD and Opiates • Reduces drug craving • Allows for lower opiate dosing • Lowers anxiety associated with pain • Reduces withdrawal symptoms • Improves sleep • Studies show 25 % drop in opioid overdose rates in states where patients could access medical marijuana http://icahn.mssm.edu/profiles/yasmin
Slide 40: Summary
Summary CBD has a beneficial impact on the intoxication, withdrawal, and relapse phases of cannabis addiction in humans CBD is associated with many neural circuits involved in the acquisition of addiction and subsequent drug seeking behaviors.
Slide 41: CBD Safety
CBD Safety • Safe compound in both animals and humans • No significant or serious adverse events, other than mild sedation and nausea. • Daily doses as high as 1500 mg were well tolerated in humans Mélissa Prud’homme , et al. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Revie
Slide 42: Toxicological assessment of hemp-based CBD
The toxicological assessment that is reported herein is the first known of its kind since the 1981 Rosenkrantz et al.’s publication with respect to published toxicology data on CBD, hemp, or hemp extracts Given the broad physiological actions of CBD and other hemp - derived phytocannabinoids , this
Slide 43: In Summary – It's all About Neurotransmitters
In Summary – Its all About Neurotransmitters
Slide 44: In Summary
In Summary: • FDA Approval of GW Pharma is a game changer for allowing prescription CBD products to market • The use of CBD as a dietary supplement is now past the tipping point and accepted by general public and medical professionals as: • Safe • Effective for a wide range of conditions, by reducti
Slide 45: Thank you
Thank you