Pmgc Holdings Inc. · NASDAQ:ELAB
Pmgc — Elevai Labs — Investor Presentation (July 2024)
66 slides from Pmgc's investor presentation, Jul 16, 2024
Slide 1: ELEVAI
Slide 2: Next Generation Skin & Scalp Rejuvenation: Stem Cell Exosomes + Mitochondrial Biogenesis
2 NEXT GENERATION SKIN & SCALP REJUVENATION: STEM CELL EXOSOMES + MITOCHONDRIAL BIOGENESIS TECHNOLOGY DISCOVERED USING AI Jordan R. Plews, PhD & Keshav K. Singh, PhD
Slide 3: Jordan R. Plews, PhD
Jordan R. Plews, PhD Cofounder of ELEVAI Labs Inc. (Nasdaq: ELAB) CEO of ELEVAI Skincare Inc. Background: Biochemical Engineer & Stem Cell Scientist . Academic research completed at University College London, University of Sheffield, and Stanford University . Experience with human stem cells, molecu
Slide 4: What Is Aging?
WHAT IS AGING? ELEVAI LABS
Slide 5: What Is Aging?
WHAT IS AGING? DEFINITION: “Aging is the natural process of becoming older, which involves the gradual decline of physical and biological functions over time. ” 5
Slide 6: What Is Aging?
WHAT IS AGING? DEFINITION: “Aging is the natural process of becoming older, which involves the gradual decline of physical and biological functions over time. ” Aging is a degenerative disease that results in the gradual decline of physical and biological functions over time. 6
Slide 7: What Is Aging?
WHAT IS AGING? DEFINITION: “Aging is the natural process of becoming older, which involves the gradual decline of physical and biological functions over time. ” Aging is a degenerative disease that results in the gradual decline of physical and biological functions over time. 7
Slide 8: What Are Exosomes?
WHAT ARE EXOSOMES? Exosomes act as important messengers between cells, protecting and transporting the body’s natural messages. CELL A Mesenchymal Stem Cell (MSC) CD90+, CD105+, CD73+, CD45 - CELL B Dermal Fibroblast EXOSOMES nanoencapsulated RNA & Protein
Slide 9: Why Do We Age?
WHY DO WE AGE? ELEVAI LABS
Slide 10: Aging Explained Simply
AGING EXPLAINED SIMPLY Rate of Repair/Regeneration Rate of Damage/Degeneration TIME Signs of Aging are repaired faster than they accumulate Signs of Aging are repaired slower than they accumulate
Slide 11: Aging Explained Simply
AGING EXPLAINED SIMPLY Rate of Repair/Regeneration Rate of Damage/Degeneration Collagen & Elastin (ECM) Reactive Oxygen Species (ROS’s) Genes linked to senescence Growth Factor Production TIME Signs of Aging are repaired faster than they accumulate Signs of Aging are repaired slower than they accumu
Slide 12: Aging Explained Simply
AGING EXPLAINED SIMPLY TIME Signs of Aging are repaired faster than they accumulate Signs of Aging are repaired slower than they accumulate Rate of Repair/Regeneration Rate of Damage/Degeneration
Slide 13: Hallmarks of Aging
HALLMARKS OF AGING ELEVAI Lae 13
Slide 14: Hallmarks of Aging Impacted by Intercellular Communication
HALLMARKS OF AGING IMPACTED BY INTERCELLULAR COMMUNICATION (EXOSOMES) 14 IMPACTED BY MITOCHONDRIAL DYSFUNCTION (ATP/ENERGY)
Slide 15: Hallmarks of Aging Impacted by Intercellular Communication
HALLMARKS OF AGING IMPACTED BY INTERCELLULAR COMMUNICATION (EXOSOMES) 15 IMPACTED BY MITOCHONDRIAL DYSFUNCTION (ATP/ENERGY)
Slide 16: Four Phases of Wound Healing
FOUR PHASES OF WOUND HEALING Source: Yang, Fan, et al. "The biological processes during wound healing." Regenerative Medicine 16.04 (2021): 373 - 390.
Slide 17: Stem Cell Exosomes Support All Phases of Wound Healing
Stem cells exosomes support all 4 phases of wound healing FOUR PHASES OF WOUND HEALING Source: Yang, Fan, et al. "The biological processes during wound healing." Regenerative Medicine 16.04 (2021): 373 - 390.
Slide 18: Topical Exosomes Post Procedure: 1hr Post RF Microneedling
1hr Post RF Microneedling TOPICAL EXOSOMES POST PROCEDURE Courtesy of Dr. Natalie Curcio, Immediately after RF Microneedling and 1hr post application of ELEVAI Empower topical exosome serum Baseline 1 Hour Post Topical ELEVAI empower Baseline 1 Hour Post Topical ELEVAI empower
Slide 19: Topical Exosomes Post Procedure: 2hr Post RF Microneedling
2hr Post RF Microneedling TOPICAL EXOSOMES POST PROCEDURE Courtesy of Dr. Tim Sayed, Immediately after Potenza RF Microneedling and 2hrs post application of ELEVAI Empower topical exosome serum Baseline 2 Hours Post Topical ELEVAI empower
Slide 20: Redness: 8 Week Result
Redness: 8 Week Result - 2x Daily Topical application Subject achieved approximately 44% reduc)on in redness in 8 weeks Photos courtesy of Trio Skincare (Walnut Creek, CA) TOPICAL EXOSOMES AT HOME
Slide 21: Key Factors in Selecting Exosomes
o Cell Source o o o Manufacturing Process Preservation / Storage Efficacy / Results KEY FACTORS IN SELECTING EXOSOMES
Slide 22: Cell Source Impacts Exosome Quality
The source from which exosomes are isolated from is of critical importance with implications on their functional use and clinical applications. STEM CELL SOURCES Umbilical Cord (Wharton’s Jelly) MSCs Placental Tissue MSCs Adipose Tissue derived MSCs Bone Marrow derived MSCs CELL SOURCE IMPACTS EXOSO
Slide 23: Cell Source Impacts Exosome Quality
The source from which exosomes are isolated from is of critical importance with implications on their functional use and clinical applications. STEM CELL SOURCES Umbilical Cord (Wharton’s Jelly) MSCs Placental Tissue MSCs Adipose Tissue derived MSCs Bone Marrow derived MSCs NON STEM CELL SOURCES Pla
Slide 24: Young Cells Produce Better Exosomes
Nedachi, Taku, et al. "Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes." Aging (Albany NY) 15.22 (2023): 12702. Key Takeaways: 1. Exosomes from young cells shown to have a positive impact on older cells 2. Exoso
Slide 25: Key Factors in Selecting Exosomes
o Cell Source o Manufacturing Process o Preservation / Storage Efficacy / Results o KEY FACTORS IN SELECTING EXOSOMES
Slide 26: Vertically Integrated Processing
VERTICALLY INTEGRATED PROCESSING 26
Slide 27: Avoid Use of Animal Derived Products
● Avoid use of animal derived products ○ Fetal Bovine Serum (FBS) is common in cell culture, but also creates unnecessary risks. 1,3 ■ Mad Cow Disease , aka Bovine Spongiform Encephalitis (BSE) ■ Currently no way to screen for BSE in live cattle and no effective way to remove the presence of BSE fro
Slide 28: Key Factors in Selecting Exosomes
o Cell Source o Manufacturing Process o Preservation / Storage o Efficacy / Results KEY FACTORS IN SELECTING EXOSOMES
Slide 29: Storage & Ease of Use
Storage & Ease of Use ● Airless Packaging: ○ Sturdy double walled airless pumps protect from oxida&on ○ Opaque containers protect from sunlight & UV damage ● No recons>tu>on required (i.e. product is a true topical serum) ● Vials require a syringe and imply injectable use (which is not allowed)
Slide 30: Exosomes: Nanosized Messengers
Exosomes: Nanosized Messengers Exosomes are created by and released from cells and are less than 1/100th the size of a cell. Source: György, B., Szabó, T.G., Pásztói, M. et al. Membrane vesicles, current state - of - the - art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68, 2667 –
Slide 31: Exosome Absorption - Hair Follicles
Hair follicle diameter: Exosome diameter: 110,000 - 293,000 nm (733x to 9766 x diameter of exosomes) 30 - 150 nm 1. Lee MS, Kossard S, Wilkinson B, Doyle JA. Quantification of hair follicle parameters using computer image analysis: a comparison of androgenetic alopecia with normal scalp biopsies. Au
Slide 32: Key Factors in Selecting Exosomes
o o Cell Source o Manufacturing Process Preservation / Storage o Efficacy / Results KEY FACTORS IN SELECTING EXOSOMES
Slide 33: 1hr Post Microneedling Topical Exosomes
1hr Post Microneedling TOPICAL EXOSOMES POST PROCEDURE Courtesy of MOBO Skin, OH - Immediately after Microneedling and 1hr post application of ELEVAI Empower topical exosome serum Before 1hr Later Before 1hr Later Before 1hr Later
Slide 34: 1hr Post Vascular Laser Topical Exosomes
1hr Post Vascular Laser (excel V+ 532nm KTP) TOPICAL EXOSOMES POST PROCEDURE Courtesy of Dr. Natalie Curcio, Immediately after excel V and 1hr post application of ELEVAI Empower topical exosome serum Baseline 1 Hour Post topical ELEVAI empower Baseline 1 Hour Post topical ELEVAI empower
Slide 35: Redness: 8 Week Result
35 Baseline 8 Weeks Photos courtesy of Trio Skincare (Walnut Creek, CA) Redness: 8 Week Result - 2x Daily Topical applica9on Subject achieved approximately 44% reduc)on in redness in 8 weeks TOPICAL EXOSOMES AT HOME Baseline 8 Weeks
Slide 36: Pigmentation Result: Twice Daily Topical Application
36 Pigmentation: 16 - week result 2x Daily Topical Application Only BEFORE AFTER BEFORE AFTER Photos courtesy of Dr. Gill (Lodi, CA)
Slide 37: Aging Explained Simply
AGING EXPLAINED SIMPLY TIME Signs of Aging are repaired faster than they accumulate Signs of Aging are repaired slower than they accumulate Rate of Repair/Regeneration Rate of Damage/Degeneration
Slide 38: Exosomes and Mitochondrial Signaling Between Tissues
h%ps:// www.quantamagazine.org/cells - across - the - body - talk - to - each - other - about - aging - 20240108/ Chemical signals released by mitochondria are somehow communicated to mitochondria in other Mssues, with consequences for how rapidly organism age EXOSOMES
Slide 39: Keshav K. Singh, PhD
Keshav K. Singh, PhD 39 Founder & Chief Scientific Officer, Yuva Biosciences Background: • Undergraduate from India in Microbiology. • PhD from Australia in Marine Biology. • Postdoc at Harvard in DNA damage, repair and mutagenesis • Faculty/Professor at Johns Hopkins • University of Alabama at Birm
Slide 40: Keshav K. Singh, PhD, Scientific Founder and CSO
Keshav K. Singh, Ph.D Scien:fic Founder and Chief Scien:fic Officer
Slide 41: New Discovery: Mitochondrial Dysfunction a Key Cause of Skin and Hair Aging
//041 www.yuvabio.com New Ground - Breaking Discovery: A Key Cause of Skin and Hair Aging is Mitochondrial Dysfunction. Keshav K Singh, Ph.D. Founding Scientist “Scientists Have Found a Way to Reverse Wrinkles and Hair Loss , According to an ‘Unprecedented’ New Study.” (July 2018)
Slide 42: Youthfulness for Life: Restoring Mitochondrial Function
Youthfulness for Life Restoring Mitochondrial Function Develop Products that Address the Root Cause of Aging by Leveraging Breakthroughs in Mitochondrial Science .
Slide 43: Mitochondrial Function Declines as We Age
Mitochondrial FuncMon Declines as We Age: Overview. //043 www.yuvabio.com
Slide 44: The Hallmarks of Aging: Mitochondrial Dysfunction
The Hallmarks of Aging: Mitochondrial Dysfunction is Critical in Driving Skin Aging and Interacts with the Other Hallmarks. • Yuva Biosciences has spent millions of dollars and several years of research to develop a technology platform that can identify compounds that improve mitochondrial function
Slide 45: Rate of Decline in Mitochondrial Function During Aging
Rate of Decline in Mitochondrial FuncMon During Aging. Overview. //045 www.yuvabio.com Mitochondrial ROS. (2023, December 3). In Wikipedia. h?ps://en.wikipedia.org/wiki/Mitochondrial_ROS The annual rate of loss is said to be 1% but trajectory increases with advancing age. The rate of mitochondrial f
Slide 46: Mitochondria Explained: Energy Creation
Mitochondria Explained: 90% of the Energy We Need to Sustain Life & Support Organ Function is Created by Mitochondria. //046 OXPHOS COMPLEX I 7 37 44 mtDNA encoded Nuclear DNA encoded Total proteins OXPHOS COMPLEX II 0 4 4 OXPHOS COMPLEX III 1 10 11 OXPHOS COMPLEX IV 3 11 14 OXPHOS COMPLEX V 2 14 16
Slide 47: Mitochondria Explained: Signalling Organelles
Mitochondria Explained: Signalling Organelles. //047 Cytochrome C H 2 O 2 NADH/NAD + AMPK mtDNA/mtRNA TCA Metabolites Cell Death Cell Function Integrated Stress Response Catabolic Switch Immune Response Cell Fate Caspase Activation Protein Thiol Oxidation HRI/GCN2 Mitochondrial Dynamics MAVS/STING/T
Slide 48: Mitochondria Are the Major Source of Oxidative Stress
www.yuvabio.com Mitochondria are the Major Source of OxidaMve Stress: Reac=ve Oxygen Species (ROS) are produced due to leakage of electron at Complex I and III. Mitochondrial ROS. (2023, December 3). In Wikipedia. h?ps://en.wikipedia.org/wiki/Mitochondrial_ROS //048
Slide 49: Mitochondrial Dysfunction and Cellular Consequences by Skin Cell Type
www.yuvabio.com Mitochondrial DysfuncMon and Cellular Consequences: By Skin Cell Types. Cellular Consequences Skin Cell Type Impaired epidermal differentiation and cornification, defective barrier function, and increased cell death Keratinocytes Impaired melanosome transport and pigmentation disorde
Slide 50: Addressing the Root Cause of Hair and Skin Aging
Addressing the Root Cause of Hair and Skin Aging: Improving Mitochondrial FuncUon Fights Hair and Skin Aging Which Has Many Benefits. Improving mitochondrial health in hair and skin cells enables them to perform ALL their assigned functions effectively! • Enhancing hair growth • Preventing hair loss •
Slide 51: Mechanism of Action: Enhancing Mitochondrial Biogenesis
Mechanism of Action at Molecular Level: Enhancing Mitochondrial Biogenesis. Our compounds upregulate key biomarkers of mitochondrial biogenesis in cells ( biomarker 1 , biomarker 2 , and biomarker 3 ). YuvaBio ® Y100 1. Applied topically to scalp skin and facial skin. BM1 BM2 BM3 2 . Compound Y 100
Slide 52: MitoGPT: AI Classifier for Mitochondrial Biogenesis
The World’s First ArMficial Intelligence Classifier for Mitochondrial Biogenesis: MitoGPT. Welcome to MitoGPT Find compounds that improve mitochondrial health | Advised by a Top AI Expert… Jeb Linton - Chief Data Scientist of TLS Division at IBM. Former CTO for AI Cognitive Security. Compound Similari
Slide 53: Clinically Validated: YuvaBio Y100 in Multiple Human Trials
Clinically Validated: YuvaBio ® Y100 is Successful in MulUple Human Trials. HAIR AGING, SKIN AGING, AND SAFETY STUDIES… • Safety trial: 54 participants. No adverse reactions or side effects were reported. • Hair aging study: 2x per day application. Leave - on. Primary clinical indication: androgeneti
Slide 54: Partnership: Yuva Biosciences and ELEVAI Labs
ExciMng Partnership: Yuva Biosciences and ELEVAI Labs Octane’s AestheUcs Tech Forum – People’s Choice Award Winners 2022 and 2023. Greg Schmergel, Yuva Biosciences People’s Choice Award Winner Octane Aesthetics Tech Forum 2023 Two recognized winners of the prestigious Octane Aesthetics Tech Forum pa
Slide 55: The ELEVAI E-Series
E L E V A I E - S E R I E S The ELEVAI E - Series TM
Slide 56: Hair Loss Affects Approximately 60% of Men and 50% of Women
Approximately 60% of men and 50% of women experience some form of hair loss during their lifetime. In the United States alone, around 56 million people are affected by hair loss, including 35 million men and 21 million women.
Slide 57: Rooted in Nature, Perfected by Science
Rooted in nature, perfected by science.
Slide 58: The ELEVAI S-Series
E L E V A I S - S E R I E S The ELEVAI S - Series The ELEVAI E - Series TM
Slide 59: Introducing the ELEVAI Root Renewal System
INTRODUCING The ELEVAI Root Renewal System Rooted in nature, perfected by science
Slide 60: Addressing Hair Issues
E L E V A I S - S E R I E S COMMON CAUSES OF HAIR LOSS • Androgenetic Alopecia • Nutritional Deficiencies • Stress • Medications • Lifestyle Factors CHALLENGES WITH CURRENT TREATMENTS • Side effects • Limited efficacy • Cost • Not addressing underlying causes Addressing Hair Issues
Slide 61: First in Class Dual Mechanism Technology
E L E V A I S - S E R I E S First in Class Dual Mechanism Technology This innovative dual mechanism approach targets the hair root and works synergistically to achieve visual improvements in hair growth thickness and density while reducing the appearance of hair shedding and thinning hair. • PREx ,
Slide 62: Clarify Shampoo
E L E V A I S - S E R I E S clarify Shampoo The clarify Shampoo is a treatment shampoo designed to gently yet effectively remove excess oil, residue, and environmental pollutants, leaving your hair and scalp feeling clean and refreshed. 150 ML/ 5 FL OZ
Slide 63: Nourish Conditioner
E L E V A I S - S E R I E S nourish Condi@oner The nourish Conditioner is a treatment conditioner that helps to moisturize and protect hair from daily damage, maintain hair health, and improve smoothness and shine. 150 ML 5 FL OZ
Slide 64: Renew Exosome Scalp Serum
E L E V A I S - S E R I E S The renew Exosome Scalp Serum is a first - in - class topical formulation powered by a combination of two proprietary technologies, ELEVAI Precision Regenerative Exosome Technology (PREx ) and YuvaBio Y100, a small molecule discovered using AI that supports mitochondrial
Slide 65: ELEVAI Root Renewal System
E L E V A I S - S E R I E S The ELEVAI Root Renewal System is a complete hair and scalp care system designed to clarify, nourish, and renew your hair from root to tip . BENEFITS (based on early clinical testing) • Visual improvements in hair growth, thickness, and density • Reduces the appearance of
Slide 66: Meet Us at Booth #511
Meet us at BOOTH #511 Scan QR code below to connect: Jordan R. Plews, Ph.D. Co - Founder & CEO, ELEVAI (Nasdaq: ELAB) contact@elevaiskincare.com Keshav K. Singh, Ph.D. Scientific Founder, Yuva Biosciences Keshav@yuvabio.com