Corbus Pharmaceuticals Holdings, Inc. · NASDAQ:CRBP
Corbus Pharmaceuticals — Investor Presentation (September 2026)
58 slides from Corbus Pharmaceuticals's investor presentation, Sep 14, 2026
Slide 1: Connecting Innovation to Purpose Corporate Presentation
Connecting Innovation to Purpose Corporate Presentation September 14, 2026 Exhibit 99.2
Slide 2: Forward-looking statements
This presentation contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act of 1995, as amended, including those relating to the Company’s trial resul
Slide 3: Differentiated portfolio in Oncology and Obesity Overview
OBESITY Differentiated portfolio in Oncology and Obesity Overview Oncology Nectin 4 ADC – OPSCC (lead), cervical cancer Promising Phase 1/2 2L data: 43% ORR at 3.6 mg/kg in OPSCC Registrational 2L OPSCC study (TEMPO-1) underway CRB-701 + pembrolizumab data in 1L OPSCC in Q1 2027 Potential BLA filing
Slide 4: Focused and diversified pipeline
Focused and diversified pipeline Therapy Mechanism of Action Indication (rights) Pre-Clinical Phase 1 Phase 2 Phase 3 Milestones CRB-701 Nectin-4 ADC positive solid tumors 2L OPSCC (US + Europe) First patient expected to be dosed in TEMPO-1 in Sept. 2026 1L OPSCC (US + Europe) Topline ORR data expec
Slide 5: CRB-701 Next-Generation Nectin-4 ADC targeting OPSCC and cervical cancers
CRB-701 Next-Generation Nectin-4 ADC targeting oropharyngeal (OPSCC) and cervical cancers
Slide 6: CRB-701: Reimagining the next-generation Nectin-4 ADC
CRB-701 DAY 1 1.25 mg/kg DAY 8 1.25 mg/kg DAY 15 1.25 mg/kg DAY 22 dose holiday DAY 28 DAY 1 CRB-701 DAY 8 dose holiday DAY 15 dose holiday DAY 22 CRB-701: Reimagining the next-generation Nectin-4 ADC Source(s): Modified image from Corbus data on file; Corbus data on file; PADCEV® FDA label MMAE = M
Slide 7: CRB-701-01 Study design (U.S. and Europe)
CRB-701-01 Study design (U.S. and Europe) cORR, confirmed objective response rate; DLT, dose-limiting toxicity; DoR, duration of response; MMAE, monomethyl auristatin E; PFS, progression-free survival; Q3W, every 3 weeks Dose Optimization (Project Optimus): HNSCC & cervical Dose escalation Dose esca
Slide 8: ASCO 2026: Key characteristics & tumor types
Baseline Characteristic HNSCC Cervical Median age (range) 62 (24–78) 54 (32–78) Sex (M/F) 89.3% / 10.7% NA / 100% ECOG PS** 0, 1, 2 47%, 52%, 1% 44%, 56%, 0% Weight in kg mean (range) 75.2 (41.3–132.8) 64.3 (39.0–99.0) Prior therapies median (range) 3 (1–9) 3 (1–7) Enrolled Tumor Types Safety Popula
Slide 9: ASCO 2026: Study safety population TRAEs
TRAE n=317 (%) Grade 3 19.2% Grade 4 0.9% Grade 5 None PERIPHERAL NEUROPATHY (broad terms*) Grade 1 and 2 7.3% Grade >3 None SKIN (most common, excluding alopecia) Pruritus 14.2% Dry skin 13.2% Rash 5.7% Grade 3 - rash 0.3% Grade ≥4 None OCULAR Overall 66.2% Grade 3 12.6% Grade 4 0.3%** DISCONTINUAT
Slide 10: ASCO 2026: Safety Summary (TRAEs, N=317)
ASCO 2026: Safety Summary (TRAEs, N=317) Source(s): ASCO April 1, 2026 data cut; *Standardized MedDRA Category Search; **general rash; TRAEs = Treatment-Related Adverse Events; Only 1 in 4 patients experienced skin AEs (excluding alopecia) Just a single Grade 3 event (1/317**) and no Grade >4 No cas
Slide 11: CRB-701 in 2L+ Oropharyngeal Head and Neck Cancer (OPSCC)
CRB-701 in 2L+ Oropharyngeal Head and Neck Cancer (OPSCC)
Slide 12: What is Oropharyngeal Squamous Cell Carcinoma (OPSCC)?
What is Oropharyngeal Squamous Cell Carcinoma (OPSCC)? Source(s): Image Corbus licensed ChatGPT account; 1. Ozdogan et al 2025; 2. Sander et al, 2022; 3. Swiecicki et al 2026. DEFINITION HPV+ tumors (80–90% of OPSCC)1 Associated with higher Nectin-4 expression2 HPV+ selectivity seen with PADCEV® in
Slide 13: OPSCC is on the rise in the U.S.
OPSCC is on the rise in the U.S. as prevalence of HPV+ in HNSCC is increasing: 11% 57% over last 30 years Source(s): Data generated by Greenhill: (1) Portugal et al., 1997; (2) Dahlstrom et al., 2003; (3) Chaturvedi et al., 2008; (4) Cole et al., 2012; (5) Bauml et al., 2017; (6) Wu et al., 2021;
Slide 14: OPSCC growing in HNSCC: HPV+ incidence growing while HPV- decreasing
↑ HPV+ Pathway ↓ HPV- Pathway Two Opposing Drivers ↑ HPV+ HNSCC (younger, non-smoking patients) ↓ HPV− HNSCC (older, heavy smoker/drinker patients) OPSCC growing in HNSCC: HPV+ incidence is growing while HPV- is decreasing Source(s): Data generated by Greenhill; (1) Chaturvedi, A. K. et al., 2011; (
Slide 15: Summary of OPSCC U.S. Epidemiology and Treatment Eligibility
Summary of OPSCC U.S. Epidemiology and Treatment Eligibility Source(s): *LifeSci Consulting Qualitative Market Research ; **American Cancer Society Statistics 2026 for Oral Cavity and Oropharyngeal Cancer: 13,150 deaths and the Company estimates 7,000 attributable to OPSCC Total Prevalence: ∼114,000
Slide 16: ASCO 2026: Key characteristics in HNSCC and subsets
Enrolled Tumor Types HNSCC All-comers ( n=75 ) OPSCC Subset ( n=41 ) Other HNSCC anatomical subsets ( n=34 ) Median age (range) 62 (24–78) 62.0 (36–77) 62 (24–78) Sex (M/F) 89.3% / 10.7% 90.2% / 9.8% 88.2% / 11.8% ECOG PS 0, 1, 2 47%, 52%, 1% 58.5%, 41.5%, 0% 32.4%, 64.7%, 2.9% Weight in kg mean (ra
Slide 17: OPSCC associated with HPV positivity and higher Nectin-4 levels
HNSCC ASCO 2026: OPSCC associated with HPV positivity in our study (as expected) and higher nectin-4 levels Source(s): ASCO April 1, 2026 data cut. BASELINE Nectin-4 H score>150 1 in 3 1 in 10 Nectin-4 H score>175 1 in 4 1 in 12 Nectin-4 H score>200 1 in 6 1 in 30
Slide 18: ASCO 2026: CRB-701 confirmed responses favor OPSCC
2.7 mg/kg 3.6 mg/kg cORR 20.0% (4/20) 42.9% (9/21) DCR 90.0% (18/20) 85.7% (18/21) 2.7 mg/kg 3.6 mg/kg cORR 7.1% (1/14) 0.0% (0/16) DCR 57.1% (8/14) 62.5% (10/16) ASCO 2026: CRB-701 confirmed responses favor OPSCC Source(s): ASCO April 1, 2026 data cut; Patients are summarized on the treatment and d
Slide 19: ASCO 2026: CRB-701 had longer durability in OPSCC
Subject Details WEEKS ON TREATMENT 3.6 mg/kg 2.7 mg/kg ASCO 2026: CRB-701 had longer durability in OPSCC Source(s): ASCO April 1,2026 data cut; HNSCC = Head & Neck Squamous Cell Carcinoma; OPSCC = Oropharyngeal Squamous Cell Carcinoma; DoR = Duration of Response; PFS = Progression-Free Survival HNSC
Slide 20: ASCO 2026: Efficacy summary at 3.6 mg/kg Q3W
3.6 mg/kg Q3W OPSCC ( n=21 ) Non-OPSCC ( n=16 ) cORR 42.9% 0% DCR 85.7% 62.5% DoR (months) 6.3 NA PFS (months) 5.6 2.7 % responders HPV+ 89% (8 out of 9) NA ASCO 2026: Efficacy summary at 3.6 mg/kg Q3W OPSCC is indication of choice EFFICACY Source(s): ASCO April 2026 data cut; OPSCC = Oropharyngeal
Slide 21: Contextualizing monotherapy CRB-701 and petosemtamab in 2L HPV+/OPSCC
RP2D OPSCC population Petosemtamab* (n=15)*** CRB-701** (n=21) Dosing regimen 1500 mg Q2W 3.6 mg/kg Q3W Efficacy (cORR) 13% (2/15) in OPSCC HPV+ only 50% (8/16) in OPSCC HPV+ only 43% (9/21) in OPSCC all types Median DoR (months) 6.2 in HNSCC 6.3 in OPSCC (ongoing) PFS (months) 4.9 in HNSCC 5.6 in
Slide 22: TEMPO-1 Registrational Study
TEMPO-1 Registrational Study ELIGIBLE POPULATION Recurrent OPSCC Prior Platinum & Anti–PD-(L)1 RANDOMIZED 3.6 mg/kg dose 1:1 CRB-701 Monotherapy N≈125 INVESTIGATOR’S CHOICE Monotherapy N≈125 ADAPTIVE FEATURE Interim Analysis → Sample Size Re-Estimation Seamless Phase 2 → Phase 3 Transition PRIMARY (
Slide 23: 1L OPSCC potential: precedent of Padcev + Keytruda in 1L
Padcev® + Keytruda® cORR All 39% (16/41) HPV+ 82% (9/11) HPV- 23% (7/30) Notes: TRAEs ≥ Grade 3: 41% Peripheral neuropathy: 32% 1L OPSCC potential: the precedent of Padcev® + Keytruda® in 1L Source(s): 1. Swiecicki et al 2026 2. Van Herpen ASCO 2025 3.Hanna et al 2026; cORR = confirmed Objective Res
Slide 24: Padcev added to the 2026 NCCN treatment guidelines for HNSCC
Padcev® added to the 2026 NCCN treatment guidelines* for HNSCC * National Guidelines Version 2.2026 Head and Neck Cancer –Page 119 ** Swiecicki et al 2024 Swiecicki et al 2024** Padcev® 2L+ cORR All-comers 24% (11/46) Notes: Demographics: 65% U.S. & 35% Japan No breakdown by p16 TRAEs ≥ Grade 3: 35%
Slide 25: Anticipated milestones – OPSCC
Anticipated milestones – OPSCC NEXT STEPS First patient in TEMPO-1 registrational 2L study — Sept. 2026 Report CRB-701 + pembrolizumab data in 1L — Q1 2027 Report registrational interim 2L ORR data — Q1 2028 Potential BLA filing in 2L – mid 2028
Slide 26: Cervical Cancer: Acute unmet need in 2L
Cervical Cancer Acute unmet need in 2L in poorly addressed market
Slide 27: Cervical Cancer: Commercial Opportunity for CRB-701
Cervical Cancer: Commercial Opportunity for CRB-701 Source(s): 1. https://www.cancer.org/cancer/types/cervical-cancer/about/key-statistics.html , 2. Study reveals why cervical cancer screening rates are declining, which populations are most affected - UTHealth Houston School of Public Health , 3. HP
Slide 28: Few options for 2L cervical cancer
FULL APPROVAL Few options for 2L cervical cancer Source(s): Vergote et al 2024 1L 2L Tisotumab vedotin Single-Agent Chemo Carbo + Paclitaxel +/- Beva +/- Pembrolizumab ACCELERATED APPROVAL 2021 2024 CERVICAL CANCER
Slide 29: Tivdak demonstrates a commercial potential that could be further improved
Efficacy**** ORR 17.8% PFS 4.2 months OS 11.5 months Adverse event profile**** Ocular (Black Box) 55% (all grades) Peripheral neuropathy 39% (all grades) Bleeding 51% (all grades) Rash 25% (all grades) USA numbers Value R/M patients receiving 2L treatment 38%* Annual price (WAC) $466,208** Annualize
Slide 30: ASCO 2026: Key characteristics & tumor types
Enrolled Tumor Types Safety Population Efficacy Evaluable Population Cervical 72 70 Baseline Characteristic Cervical Median age (range) 54 (32, 78) Sex (M/F) NA/100% ECOG PS 0, 1, 2 44.4%, 55.6%, 0% Weight in kg mean (range) 64.3 (39.0–99.0) Prior therapies median (range) 3 (1–7) ASCO 2026: Key char
Slide 31: CRB-701 ASCO 2026: Waterfall plot (N=70)
CRB-701 ASCO 2026: Waterfall plot (N=70) Source(s): ASCO April 2026 data cut; Patients are summarized on the treatment and dose level assigned at enrollment/randomization. Best Overall Response is displayed at the end of each bar. cCR = confirmed Complete response; cORR = confirmed Objective Respons
Slide 32: CRB-701 ASCO 2026: Swimmer plots (N=70)
Subject Details WEEKS ON TREATMENT 3.6 mg/kg 2.7 mg/kg CRB-701 ASCO 2026: Swimmer plots (N=70) Source(s): ASCO April 1, 2026 data cut; DoR = Duration of Response; PFS = Progression-Free Survival Months 2.7 mg/kg ( n=38 ) 3.6 mg/kg ( n=32 ) DoR 6.8 8.0 PFS 2.8 4.3 CERVICAL Complete Response Partial R
Slide 33: CRB-701 potential to differentiate from current standard of care in 2L
CRB-701* ( n=32 ) Tivdak® ( n=253**) IC Chemo 2L+ ( n=249*** ) Mechanism Nectin-4 ADC with MMAE payload (DAR 2) Tissue factor ADC with MMAE payload (DAR 4) Anti-metabolite, cytoskeleton disruption, topoi inhibition etc. Target population 2L 2L 2L Dosing regimen 3.6 mg/kg Q3W 2 mg/kg Q3W various Effi
Slide 34: CRB-913 Daily oral small molecule targeting chronic obesity management
CRB-913 Daily oral small molecule targeting chronic obesity management
Slide 35: Can we design a safe and tolerable CB1 inverse agonist?
“Can we design a safe and tolerable CB1 inverse agonist with competitive weight loss to incretin therapies?”
Slide 36: CB1 is a well characterized receptor in metabolism
Cannabinoid Type-1 (CB1) is a well characterized receptor (GPCR) in metabolism Note: G protein-coupled receptors (“GPCR”) are the largest and most common family of cell-surface receptors. Source: Targeting the endocannabinoid system in diabesity: Fact or fiction?, Drug Discovery Today, Deeba et al.
Slide 37: CRB-913 higher peripheral exposure and lower brain exposure vs. prior CB1s
CRB-913 higher peripheral exposure and lower brain exposure vs. prior CB1s Sources: Corbus murine data Corbus PK modeling based on Phase 1a data CRB-913 ~1/50th Brain:plasma ratio CRB-913 vs. Rimonabant1 ~1/15th Brain level CRB-913 vs. Monlunabant1 Rimonabant Otenabant Ibipinabant Taranabant Monluna
Slide 38: CANYON-1 Phase 1b obesity results
CANYON-1 Phase 1b obesity results for oral small-molecule CB1 inverse agonist Data support CRB-913’s potential to deliver a novel non-incretin oral therapy for obesity Enrolled 254 patients across 15 US clinical sites Trial representative of U.S. obesity population BMI average of 37 kg/m2 and 71% of
Slide 39: Phase 1b randomized placebo-controlled study design
A 12-week Phase 1b randomized double-blinded placebo-controlled study in adults with obesity Study design All 15 sites located in US Randomization 1:1:1:1 n=254 Placebo QD 12-Week Treatment Phase ( CRB-913 or Placebo QD ) 20mg QD 20mg QD 40mg QD 20mg QD 40mg QD 60mg QD 4-week safety follow-up Weeks
Slide 40: Baseline demographics
Baseline demographics Source: Corbus Pharmaceuticals (data on file) Baseline characteristics CRB-913 20mg ( n=65 ) CRB-913 40mg ( n=61 ) CRB-913 60mg ( n=62 ) Placebo ( n=66 ) Overall ( n=254 ) Female (%) 69.2 72.1 72.6 69.7 70.9 Caucasian (%) 67.7 65.6 75.8 54.5 65.7 Black or African American (%) 3
Slide 41: Dose-dependent weight loss with no plateauing
Dose-dependent weight loss at 12 weeks with no plateauing Efficacy estimand. The LS means, and p-values are the Mixed Model for Repeated Measures (MMRM) with percent change from baseline as the dependent variable; sex, treatment group, visit and treatment group-by-visit interaction as categorical fi
Slide 42: Majority of participants lost weight on CRB-913 compared to placebo
Majority of participants lost weight on CRB-913 compared to placebo Note: Efficacy estimand. Analysis represents weight loss from baseline measured at day 85 for those participants who completed the study. Responder thresholds are cumulative; a participant who achieves a higher percentage of body-we
Slide 43: Comparable weight loss to oral GLP-1s
Comparable weight loss to oral GLP-1s at 12 weeks Note: Efficacy estimand. These limited observations are derived from separate clinical settings, and do not represent head-to-head comparisons. For orforglipron, early clinical development evaluated a 36 mg capsule formulation; subsequent bridging es
Slide 44: Favorable safety profile with low discontinuations and no serious TRAEs
Favorable safety profile with low discontinuations and no serious TRAEs Source: CANYON-1 data Safety and tolerability CRB-913 20mg (n=65) CRB-913 40mg (n=61) CRB-913 60mg (n=62) Placebo (n=66) All Treatment-Emergent AEs (TEAEs) 39 (60.0%) 45 (73.8%) 45 (72.6%) 28 (42.4%) Severe TEAEs 3 (4.6%) 2 (3.3
Slide 45: Treatment-emergent psychiatric AEs of special interest
Treatment-emergent psychiatric AEs of special interest Source: CANYON-1 data Safety and tolerability: Psych CRB-913 20mg (n=65) CRB-913 40mg (n=61) CRB-913 60mg (n=62) Placebo (n=66) Suicidality 0 0 0 0 Depressive symptoms 0 0 1 (1.6%) (moderate) 0 Anxiety 2 (3.1%) 5 (8.2%) 3 (4.8%) 3 (4.5%) Insomni
Slide 46: CRB-913 psychiatric TEAE profile vs published GLP-1 studies
CRB-913 psychiatric TEAE profile vs published GLP-1 studies Note: These limited observations are cross trial comparison derived from separate clinical settings and do not represent head-to-head comparisons. Published safety data reflect adverse events reported over study durations longer than the 12
Slide 47: Psych AEs vs monlunabant
CRB-913 (20/40/60mg) n = 188 Monlunabant1 (10/20/50mg) n = 180 Depression 0%–1.6% 3%–8% Anxiety 3.1%–8.2% 10%–27% Irritability 6.2%–9.7% 10%–17% Insomnia 0%–4.9% 7%–17% AE study discontinuation 1.5%–9.8% 13%–42% Severe psych AE None 2%–7% Unresolved psych AEs None 5%–17% CRB-913 demonstrates favorab
Slide 48: Treatment-emergent GI AEs of special interest
Treatment-emergent GI AEs of special interest Source: CANYON-1 data Safety and tolerability: GI CRB-913 20mg (n=65) CRB-913 40mg (n=61) CRB-913 60mg (n=62) Placebo (n=66) Vomiting 3 (4.6%) 5 (8.2%) 1 (1.6%) 0 Nausea 10 (15.4%) 16 (26.2%) 14 (22.6%) 3 (4.5%) Constipation 3 (4.6%) 1 (1.6%) 3 (4.8%) 2
Slide 49: Potentially improved GI tolerability vs. commercial oral GLP-1s
CRB-9131 (60mg) Oral semaglutide2 (25mg) Orforglipron3 (36mg capsule - Cohort 1) Orforglipron3 (36mg capsule - Cohort 2) Vomiting 1.6% 31% 28% 14% Nausea 22.6% 47% 41% 48% Constipation 4.8% 20% 28% 24% Diarrhea 22.6% 18% 3% 14% Potentially improved GI tolerability vs. commercial oral GLP-1s Note: Th
Slide 50: Discontinuations due to AEs in line vs. oral GLP-1 class
Discontinuations due to AEs in line vs. oral GLP-1 class Note: These limited observations are cross trial comparison derived from separate clinical settings and do not represent head-to-head comparisons. For orforglipron, early clinical development evaluated a 36mg capsule formulation; subsequent br
Slide 51: Data supports CRB potential as new class of oral non-incretin obesity medicines
Data supports CRB 913 potential as new class of oral non-incretin obesity medicines 5% weight loss at 12 weeks with no evidence of plateauing (comparable to oral GLP-1) Psych AE profile supports benefits of peripheral restriction of CB1 therapy Favorable GI profile Competitive monotherapy & potentia
Slide 52: CRB-913 moving forward
CRB-913 moving forward Phase 2 Anticipated next steps Present Phase 1b dataset at ObesityWeek as a late breaker Engage with FDA regarding clinical development plan Initiate Phase 2 monotherapy study in 1H 2027 Evaluate potential combination therapies
Slide 53: Addressable market opportunity for CRB-913 is significant
Addressable market opportunity for CRB-913 is significant Sources: NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. The Lancet 2024
Slide 54: Leadership Upcoming Catalysts
Leadership Upcoming Catalysts
Slide 55: Senior Management Team
Senior Management Team Yuval Cohen, PhD Chief Executive Officer, Director Corbus co-founder and Chief Executive Officer since 2014. Previously the President and co-founder of Celsus Therapeutics from 2005. Sean Moran, CPA, MBA Chief Financial Officer Corbus co-founder and Chief Financial Officer since
Slide 56: Board of Directors
Board of Directors Winston Kung, MBA Director More than 20 years of senior financial, business development and investment banking experience; currently CFO of ArriVent. (NASDAQ: AVBP) Yuval Cohen, PhD Chief Executive Officer, Director Corbus co-founder and Chief Executive Officer since 2014. Previousl
Slide 57: Anticipated corporate milestones
Anticipated corporate milestones Commence registrational study in 2L OPSCC CRB-701 + pembrolizumab in 1L OPSCC data Interim ORR readout in 2L OPSCC Potential BLA filing for 2L OPSCC September 2026 Q1 2027 Q1 2028 Mid 2028 CRB-701 Additional Phase 1b data at ObesityWeek® 2026 Initiate Phase 2 monothe
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