Simulations Plus, Inc. · NASDAQ:SLP

Simulations Plus — Q4 2025 Earnings Presentation

21 slides from Simulations Plus's earnings presentation, Dec 1, 2025

  1. Slide 1: Earnings Call: Q4 - FY25

    Earnings Call: Q4 - FY25 December 1, 2025

  2. Slide 2: Safe Harbor Statement

    Safe Harbor Statement Except for historical information, the matters discussed in this presentation are forward-looking statements that involve risks and uncertainties. Words like “believe,” “will”, “can”, “expect,” “anticipate” and similar expressions (or the negative of such terms, as well as othe

  3. Slide 3: Fourth Quarter 2025 Highlights

    Fourth Quarter 2025 Highlights Current period $17.5M -6% ($0.03) $0.10 20% Revenue Revenue Diluted EPS Adj. Adj. EBITDA Decline Diluted EPS Margin Prior Year Comparison (FY24) $18.7M +19% $0.04 $0.18 22% Revenue Revenue Diluted EPS Adj. Adj. EBITDA Growth Diluted EPS Margin

  4. Slide 4: Full year 2025 Highlights

    Full year 2025 Highlights Current period $79.2M +13% ($3.22) $1.03 28% Revenue Revenue Diluted EPS (1) Adj. Adj. EBITDA Growth Diluted EPS Margin Prior Year Comparison (FY24) $70.0M +18% $0.49 $0.95 29% Revenue Revenue Diluted EPS Adj. Adj. EBITDA Growth Diluted EPS Margin (1) Diluted EPS includes a

  5. Slide 5: Software Highlights

    Software Highlights – Overall software revenue decline of 9% for 4Q25 and 12% growth for full year General – Renewal rates impacted by client consolidations and site closures ADMET Predictor® GastroPlus® MonolixSuite™ QSP/QST Software Pro-ficiency® DISCOVERY DEVELOPMENT DEVELOPMENT DEVELOPMENT CLINI

  6. Slide 6: Services Highlights

    Services Highlights – Overall services revenue decline of 3% for 4Q25 and revenue growth of 15% for FY25 General – Total backlog $18.0M, over 91% expected to be converted to revenue within 12 months PBPK Services PKPD Services QSP/QST Services Med Comm Services DEVELOPMENT DEVELOPMENT DEVELOPMENT CO

  7. Slide 7: Financial Results

    Financial Results $18.7M +19% $0.04 $0.18 22% Revenue Revenue Diluted EPS Adj. Diluted EPS Adj. EBITDA Growth Margin

  8. Slide 8: Revenue - Q4 FY25

    Revenue - Q4 FY25 (in millions) 4Q25 Mix -6% -9% -3% Total Revenue Software Revenue Services Revenue Decline Decline Decline 4Q24 Mix

  9. Slide 9: Revenue - Fiscal 2025

    Revenue - Fiscal 2025 (in millions) FY25 Mix +13% +12% +15% Total Revenue Software Revenue Services Revenue Growth Growth Growth FY24 Mix

  10. Slide 10: Software Solutions as % of Software Revenue

    Software Solutions as % of Software Revenue 4Q25 FY25 Fourth Quarter Highlights Discovery ADMET Predictor® • 9 new clients • 5 upsells to existing clients Development GastroPlus® • 11 new clients • 8 upsells to existing clients MonolixSuite™ • 7 new clients • 5 upsells to existing clients Discovery

  11. Slide 11: Software Performance Metrics - Q4 FY25

    Software Performance Metrics - Q4 FY25 Commercial Clients Avg. Revenue per Client Renewal Rate (in thousands) (fee based)

  12. Slide 12: Software Performance Metrics - Fiscal 2025

    Software Performance Metrics - Fiscal 2025 Commercial Clients Avg. Revenue per Client Renewal Rate Clients (in thousands) (fee based) (end of period)

  13. Slide 13: Services Solutions as % of Services Revenue

    Services Solutions as % of Services Revenue 4Q25 FY25 Development Development Commercialization Commercialization

  14. Slide 14: Services Performance Metrics

    Services Performance Metrics Total Projects Backlog (in millions)

  15. Slide 15: Income Statement Summary - Q4 FY25

    Income Statement Summary - Q4 FY25 (1) (in millions, except Diluted EPS and Adjusted Diluted EPS) 4Q25 % of Rev 4Q24 % of Rev Revenue $17.5 100% $18.7 100% Cost of revenue 7.6 44% 11.8 63% Gross profit 9.8 56% 6.8 37% R&D 1.7 10% 1.9 10% S&M 2.7 15% 2.6 14% G&A excluding nonrecurring 4.8 27% 1.8 9%

  16. Slide 16: Income Statement Summary - Fiscal 2025

    Income Statement Summary - Fiscal 2025 (1) (in millions, except Diluted EPS and Adjusted Diluted EPS) FY25 % of Rev FY24 % of Rev Revenue $79.2 100% $70.0 100% Cost of revenue 33.0 42% 26.9 38% Gross profit 46.2 58% 43.2 62% R&D 6.9 9% 5.8 8% S&M 11.9 15% 8.9 13% G&A excluding nonrecurring 19.5 25%

  17. Slide 17: Balance Sheet Summary

    Balance Sheet Summary (1) (in millions) August 31, 2025 August 31, 2024 Cash and short-term investments $32.4 $20.3 Other current assets 19.2 19.1 Long term assets 80.4 157.3 Total assets $131.9 $196.6 Current liabilities 6.7 12.1 Long-term liabilities 0.4 2.1 Total liabilities 7.1 14.2 Shareholders

  18. Slide 18: Fiscal 2026 Guidance

    Fiscal 2026 Guidance Guidance Total Revenue $79M - $82M Total Revenue Growth 0% - 4% Software Revenue Mix 57% - 62% Adjusted EBITDA (1) Margin 26% - 30% Adjusted Diluted EPS (2) $1.03 - $1.10 (1) Adjusted EBITDA represents net income excluding the effect of interest expense (income), provision (bene

  19. Slide 19: Adjusted EBITDA Non-GAAP Reconciliation

    Adjusted EBITDA Non-GAAP Reconciliation (1) (in thousands) 4Q25 4Q24 FY25 FY24 Net (loss) income ($681) $843 ($64,718) $9,954 Excluding: Interest income and expense, net (239) (213) (722) (4,375) Provision for income taxes 1,570 20 (4,659) 2,457 Depreciation and amortization 1,354 2,206 8,211 5,665

  20. Slide 20: Adjusted Diluted EPS Non-GAAP Reconciliation

    Adjusted Diluted EPS Non-GAAP Reconciliation (1) (in thousands, except Diluted EPS and Adjusted Diluted EPS) 4Q25 4Q24 FY25 FY24 Net (loss) Income ($681) $843 ($64,718) $9,954 Excluding: Amortization 1,242 2,059 7,667 5,163 Stock-based compensation 1,389 1,387 5,814 5,940 (Gain) loss on currency exc

  21. Slide 21: Thank You

    Thank You Investor Relations Contact: Lisa Fortuna Financial Profiles slp@finprofiles.com | +1-310-622-8251

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