10x Genomics, Inc. · NASDAQ:TXG
10x Genomics — 38th Annual J.P. Morgan Healthcare Conference (January 2020)
33 slides from 10x Genomics's conference presentation, Jan 14, 2020
Slide 1: Serge Saxonov, CEO, Co-Founder
Serge Saxonov CEO, Co-Founder
Slide 2: Safe Harbor Statement
Safe Harbor Statement Certain statements in this presentation and the accompanying oral commentary are “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to th
Slide 3: 10x Today
10x Today $170M+ First 3 quarters of 2019 revenue 75% Revenue growth as of Q3 1,500+ Installed instruments ~$150K Consumable pull-through 700+ Peer reviewed publications © 10X GENOMICS, INC. 2020. 3
Slide 4: Century of Biology
Century of Biology © 10X GENOMICS, INC. 2020. 4
Slide 5: Biology is Immensely Complex
Biology is Immensely Complex 3 billion DNA bases in the genome Each cell with its own epigenetic program Transcribed into tens of thousands of mRNA molecules Each cell with a unique set of expressed genes 40 trillion cells Translated into tens of thousands of proteins Each immune cell with its own u
Slide 6: The Need for High Resolution at Massive Scale
The Need for High Resolution at Massive Scale Genomics-Led Path to Understanding Human Biology Second Phase First Phase Focus on DNA Expand to address all of biology Compile the ‘parts list’ Understand the parts and of human biology learn how to manipulate them Human Genome Project Genome wide assoc
Slide 7: Gene Expression at the Right Resolution and Scale
Gene Expression at the Right Resolution and Scale Conventional gene expression Single cell data for thousands of cells tSNE2 tSNE2 tSNE1 tSNE1 © 10X GENOMICS, INC. 2020. 7
Slide 8: Major Discoveries Across Life Sciences
Major Discoveries Across Life Sciences © 10X GENOMICS, INC. 2020. 8
Slide 9: Deep Expertise Across Diverse Disciplines
Deep Expertise Across Diverse Disciplines Hardware Chemistry Biology Software Data © 10X GENOMICS, INC. 2020. 9
Slide 10: Complete Solutions
Complete Solutions Instruments Consumables Software © 10X GENOMICS, INC. 2020. 10
Slide 11: Innovation Engine
Innovation Engine Next GEM Platform Visium Platform Cell Surface CRISPR Antigen Proteins Profile Specificity Single Cell Single Cell (v3) Single Cell CNV ATAC Gene Expression High Definition Immunology Single Cell Linked-Read Gene Expression 2019 Genome Sequencing 2018 2017 Two successful acquisitio
Slide 12: Product Platforms
Product Platforms Traditional Platforms Chromium Visium . Bulk Single Cell Spatial © 10X GENOMICS, INC. 2020. 12
Slide 13: Chromium Platform: Millions of Parallel Reactions
Chromium Platform: Millions of Parallel Reactions Sample Chromium Controller Next generation Analysis and and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 13
Slide 14: Visium Platform: Capturing Spatial Information
Visium Platform: Capturing Spatial Information Sample Visium Next generation Analysis and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 14
Slide 15: Rapid Growth in Publications Across Life Science
Rapid Growth in Publications Across Life Science 707 586 468 370 286 198 Cumulative 146 publications 96 68 27 42 16 2017 2018 2019 © 10X GENOMICS, INC. 2020. 15
Slide 16: Replacing the Legacy Toolkit Across Biology
Replacing the Legacy Toolkit Across Biology DNA RNA • NGS • Microarrays • Capillary electrophoresis (CE) • Microscopy T- and B-cell receptors • Microarrays • qPCR / PCR • Similar tools to surface proteins • NGS methods CRISPR screening DNA segment copy Gene expression • Liquid handlers number variat
Slide 17: Underpenetrated Market: Real-Time PCR Comparison
Underpenetrated Market: Real-Time PCR Comparison ~50,000 1,500+ Real-time PCR units globally Chromium Instruments Large global opportunity © 10X GENOMICS, INC. 2020. 17
Slide 18: Creating New Markets Across Life Science Research
Creating New Markets Across Life Science Research Science and tools-based transformation of healthcare Global life science research tools $50B+ Applications where 10x offers immediate alternatives $13B or is complementary Adoption within We view much of this high throughput total market opportunity
Slide 19: Focused and Experienced Commercial Organization
Focused and Experienced Commercial Organization 96 of the top 100 global research institutions 19 of top 20 global biopharmaceutical companies Industry Leadership Named partner Human Cell Atlas and other large projects 1,500+ instruments sold since mid-2015 Low customer concentration, no direct acco
Slide 20: Chromium Use Case: University of Pittsburgh
Chromium Use Case: University of Pittsburgh Single cell genomics core facility supports early adoption One placement has grown to over 14 Individual placements are typically shared by several labs with between 2-5 users University of Pittsburgh outsources nearly all of its sequencing to third- party
Slide 21: Global Commercial Footprint
Global Commercial Footprint North America EMEA APAC 57% of revenue 21% of revenue 22% of revenue High touch direct organization of 200+ FTEs with 80+ commissioned sales executives Direct in North America and most EU countries with commercial partners supporting the rest of world © 10X GENOMICS, INC.
Slide 22: 700 Patents Issued / Filed
700 Patents Issued / Filed Chromium Single Cell Visium Spatial 180+ patents filed Key Platforms Technologies Partitioning techniques Array designs and fabrication Barcoding assays Spatial barcoding Instrumentation and software Sample preparation Key Application Areas Gene Expression Immunology DNA E
Slide 23: © 10X GENOMICS, INC. 2020.
© 10X GENOMICS, INC. 2020. 23
Slide 24: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming DNA Epigenome RNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 24
Slide 25: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming Epigenome RNA DNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 25
Slide 26: Targeted and Flexible Experiments
Targeted and Flexible Experiments Targeting Cell Plexing 50-75% drop in More experiments, 10-fold sequencing costs increase in samples Measure a panel of Pool 2 to 12 samples together 10 to 1,000 genes on a single channel © 10X GENOMICS, INC. 2020. 26
Slide 27: The Future: 10M cells
The Future: 10M cells Cells per Routine Experiment 10 100 1,000 10,000 100,000 1,000,000 10,000,000 Pre-10x 10x cells 2014 2015 2016 2017 2018 2019 2020 2021 2022 © 10X GENOMICS, INC. 2020. 27
Slide 28: Visium: Immunohistochemistry with Gene Expression
Visium: Immunohistochemistry with Gene Expression Immunohistochemistry (IHC) Visium Gene Expression IHC + Visium Gene Expression + = CD3 CD29 DAPI CD3 RNA Selected from a transcriptome Merged © 10X GENOMICS, INC. 2020. 28
Slide 29: Visium: Ultra High Plex Protein Analysis
Visium: Ultra High Plex Protein Analysis Visium Protein Analysis IHC © 10X GENOMICS, INC. 2020. 29
Slide 30: Visium: FFPE on Spatial Gene Expression
Visium: FFPE on Spatial Gene Expression FFPE Recently fixed 7-year archival Standard tissue preservation Mouse brain Breast cancer © 10X GENOMICS, INC. 2020. 30
Slide 31: Towards a Comprehensive View of Biology
Towards a Comprehensive View of Biology Gene Expression Immunology DNA Epigenomics Proteins Chromium Single Cell Visium Spatial © 10X GENOMICS, INC. 2020. 31
Slide 32: © 10X GENOMICS, INC. 2020.
© 10X GENOMICS, INC. 2020. 32
Slide 33: References
References Slide 3 Revenue and revenue growth through first three quarters of 2019. Installed instruments since mid-2015. Annual consumable pull-through per instrument as of FY 2018. Peer reviewed publications for year ended 2019. 7 t-SNE projection of approximately 10,000 mouse brain cells derived
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