10x Genomics, Inc. · NASDAQ:TXG

10x Genomics — 40th Annual Cowen Health Care Conference (March 2020)

51 slides from 10x Genomics's conference presentation, Mar 3, 2020

Slide 1: Mastering Biology to Advance Human Health
Mastering Biology to Advance Human Health Serge Saxonov CEO, Co-Founder
Slide 2: Safe Harbor Statement
Safe Harbor Statement Certain statements in this presentation and the accompanying oral commentary are “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to th
Slide 3: 10x Today
10x Today $246M 2019 revenue 68% Revenue growth YoY 1,650+ Instruments sold $150K+ Consumable pull-through 700+ Peer reviewed publications © 10X GENOMICS, INC. 2020. 3
Slide 5: Biology is Immensely Complex
Biology is Immensely Complex 3 billion DNA bases in the genome Each cell with its own epigenetic program Transcribed into tens of thousands of mRNA molecules Each cell with a unique set of expressed genes 40 trillion cells Translated into tens of thousands of proteins Each immune cell with its own u
Slide 6: The Need for High Resolution at Massive Scale
The Need for High Resolution at Massive Scale Genomics-Led Path to Understanding Human Biology Second Phase First Phase Focus on DNA Expand to address all of biology Compile the ‘parts list’ Understand the parts and of human biology learn how to manipulate them Human Genome Project Genome wide assoc
Slide 7: Gene Expression at the Right Resolution and Scale
Gene Expression at the Right Resolution and Scale Conventional gene expression Single cell data for thousands of cells tSNE2 tSNE2 tSNE1 tSNE1 © 10X GENOMICS, INC. 2020. 7
Slide 9: Deep Expertise Across Diverse Disciplines
Deep Expertise Across Diverse Disciplines Hardware Chemistry Biology Software Data © 10X GENOMICS, INC. 2020. 9
Slide 11: Innovation Engine
Innovation Engine Next GEM Platform Visium Platform Cell Surface CRISPR Antigen Proteins Profile Specificity Single Cell Single Cell (v3) Single Cell CNV ATAC Gene Expression High Definition Immunology Single Cell Linked-Read Gene Expression 2019 Genome Sequencing 2018 2017 Two successful acquisitio
Slide 12: Product Platforms
Product Platforms Traditional Platforms Chromium Visium . Bulk Single Cell Spatial © 10X GENOMICS, INC. 2020. 12
Slide 13: Chromium Platform: Millions of Parallel Reactions
Chromium Platform: Millions of Parallel Reactions Sample Chromium Controller Next generation Analysis and and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 13
Slide 14: Visium Platform: Rich Spatial Characterization
Visium Platform: Rich Spatial Characterization Sample Visium Next generation Analysis and consumables sequencer visualization software Less than 25% of customers own a DNA sequencer © 10X GENOMICS, INC. 2020. 14
Slide 15: Rapid Growth in Publications Across Life Science
Rapid Growth in Publications Across Life Science © 10X GENOMICS, INC. 2020. 15
Slide 16: Replacing the Legacy Toolkit Across Biology
Replacing the Legacy Toolkit Across Biology © 10X GENOMICS, INC. 2020. 16
Slide 17: Underpenetrated Market: Real-Time PCR Comparison
Underpenetrated Market: Real-Time PCR Comparison ~50,000 1,650+ Real-time PCR units globally Chromium Instruments © 10X GENOMICS, INC. 2020. 17
Slide 18: Creating New Markets Across Life Science Research
Creating New Markets Across Life Science Research Science and tools-based transformation of healthcare Global life science research tools $50B+ Applications where 10x offers immediate alternatives $13B or is complementary Adoption within We view much of this high throughput total market opportunity
Slide 19: Focused and Experienced Commercial Organization
Focused and Experienced Commercial Organization 96 of the top 100 global research institutions 19 of top 20 global biopharmaceutical companies Industry Leadership Named partner Human Cell Atlas and other large projects 1,650+ instruments sold since mid-2015 Low customer concentration, no direct acco
Slide 20: Chromium Use Case: University of Pittsburgh
Chromium Use Case: University of Pittsburgh Single cell genomics core facility supports early adoption One placement has grown to over 14 Individual placements are typically shared by several labs with between 2-5 users University of Pittsburgh outsources nearly all of its sequencing to third- party
Slide 21: Global Commercial Footprint
Global Commercial Footprint North America EMEA APAC 57% of revenue 23% of revenue 20% of revenue High touch direct organization of 200+ FTEs with 80+ commissioned sales executives Direct in North America and most EU countries with commercial partners supporting the rest of world © 10X GENOMICS, INC.
Slide 22: 700 Patents Issued / Filed
700 Patents Issued / Filed Chromium Single Cell Visium Spatial Analysis 180+ patents filed Key Platforms Technologies Partitioning techniques Array designs and fabrication Barcoding assays Spatial barcoding Instrumentation and software Sample preparation Key Application Areas Gene Expression Immunol
Slide 23: Exceptional Financial Profile
Exceptional Financial Profile +67% +49% y/y 68% 2019 revenue growth +76% y/y +96% y/y +97% y/y +97% y/y +113% y/y +128% y/y y/y 2017 2018 2019 $158K 75% 84% Instrument pull-through1 Gross margin Revenue from consumables 1. Annual consumable pull-through per instrument for the year ended December 31,
Slide 25: Chromium Single Cell ATAC + Gene Expression
Chromium Single Cell ATAC + Gene Expression • Deeply characterize cell types and states • Connect regulatory elements and gene activity • Interpret epigenetic profiles using expression markers © 10X GENOMICS, INC. 2020. 25
Slide 26: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming DNA Epigenome RNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 26
Slide 27: Unlocking Rules of Epigenetic Programming
Unlocking Rules of Epigenetic Programming Epigenome RNA DNA Proteins Blueprint Program Output Results Directly linking the program and output from the same cell © 10X GENOMICS, INC. 2020. 27
Slide 28: High Concordance Between the Two Read-Outs
High Concordance Between the Two Read-Outs GEX ATAC 24,000 PBMCs © 10X GENOMICS, INC. 2020. 28
Slide 29: Dive Deep Where It Matters
Dive Deep Where It Matters Discover novel disease-specific open chromatin regions ATA C Monocytes 24kb Normal B cells Tumor B cells © 10X GENOMICS, INC. 2020. 29
Slide 30: Targeted and Flexible Experiments
Targeted and Flexible Experiments Targeting Cell Plexing Estimated 50-75% drop in More experiments, sequencing costs expected 10-fold increase in samples Measure a panel of Pool 2 to 12 samples together 10 to 1,000 genes on a single channel © 10X GENOMICS, INC. 2020. 30
Slide 31: Targeted Gene Expression
Targeted Gene Expression ● More flexibility ● More scale ● More applications Single Cell Single Cell Spatial Gene Expression Immune Profiling Gene Expression © 10X GENOMICS, INC. 2020. 31
Slide 32: Targeted Gene Expression, Built the 10x Way
Targeted Gene Expression, Built the 10x Way Hybrid capture enrichment for versatile, sensitive, customizable targeting © 10X GENOMICS, INC. 2020. 32
Slide 33: Ready-to-use 10x Genomics Content Offering
Ready-to-use 10x Genomics Content Offering Fixed gene panels with comprehensive content • Tissue specific marker genes • Major signaling pathways • Common biomarkers Human Pan-Cancer Human Gene Signature • Disease targets for drug discovery ~1250 genes ~1140 genes Human Immunology Human Neuroscience
Slide 34: From Discovery to Focused Transcriptomics
From Discovery to Focused Transcriptomics Targeted product built for 10x assays Increased experimental efficiency Reduced sequencing cost WTA and targeted gene expression from the same cells Expected 80% 80%reduction reduction Core assay compatibility Content and customization © 10X GENOMICS, INC. 2
Slide 35: Cell Multiplexing
Cell Multiplexing ● Flexible Design ● Higher Throughput ● Species/Cell Type Agnostic ● Nuclei Compatible ● Fully Supported Software Single Cell Single Cell Gene Expression Immune Profiling © 10X GENOMICS, INC. 2020. 35
Slide 36: Cell Multiplexing, Built The 10x Way
Cell Multiplexing, Built The 10x Way Enabling routine profiling of hundreds of thousands to millions of cells Lipid based More cells Species agnostic 20k per channel | 160k per chip Nuclei + Cells More Samples 12 per channel | 96 per chip 10x product compatible © 10X GENOMICS, INC. 2020. 36
Slide 38: The Future: 10M cells
The Future: 10M cells Cells per Routine Experiment 10 100 1,000 10,000 100,000 1,000,000 10,000,000 Pre-10x 10x cells 2014 2015 2016 2017 2018 2019 2020 2021 2022 © 10X GENOMICS, INC. 2020. 38
Slide 39: Support for New Products in Cell Ranger
Support for New Products in Cell Ranger Getting to better results faster Targeted Gene Expression Cell Multiplexing Cell Ranger Enhancements • 3’ and 5’ Gene Expression • Gene Expression • Up to 4x faster runtime • Multi-sample aggregation • Immune Profiling • Dual-indexed read support • Support for
Slide 40: Visium: Immunohistochemistry with Gene Expression
Visium: Immunohistochemistry with Gene Expression Immunohistochemistry (IHC) Visium Gene Expression IHC + Visium Gene Expression + = CD3 CD29 DAPI CD3 RNA Selected from a transcriptome Merged © 10X GENOMICS, INC. 2020. 40
Slide 41: Visium: Targeted Gene Expression
Visium: Targeted Gene Expression Whole Transcriptome, Standard Visium Reads per spot: 50,000 Pan-Cancer Panel Reads per spot: 10,000 © 10X GENOMICS, INC. 2020. 41
Slide 42: Visium: Ultra High Plex Protein Analysis
Visium: Ultra High Plex Protein Analysis Visium Protein Analysis IHC CD29 CD4 © 10X GENOMICS, INC. 2020. 42
Slide 43: Protein Protein Protein
Immunofluorescence on Visium Feature Barcode CD29 CD4 Gene expression clustering Protein Protein Protein mRNA mRNA mRNA CD3 CD8 CD4 © 10X GENOMICS, INC. 2020. 44
Slide 44: Visium: FFPE on Spatial Gene Expression
Visium: FFPE on Spatial Gene Expression FFPE Recently fixed 7-year archival Standard tissue preservation Mouse brain Breast cancer © 10X GENOMICS, INC. 2020. 45
Slide 45: FFPE Enablement
FFPE Enablement Fresh Frozen FFPE FFPE (Standard Visium) (Standard Visium) (Modified Protocol) Spot Clustering (All Genes) Single Gene Expression (Prkcd) © 10X GENOMICS, INC. 2020. 46
Slide 46: Visium FFPE on Ovarian Sarcoma Tissue
Visium FFPE on Ovarian Sarcoma Tissue Immune cells Extracellular matrix Sarcoma Immune cells Carcinoma Adipose Eva Gracia Villacampa Linda Kvastad Ludvig Larsson Joakim Lundeberg 1 2 Sequential tissue sections © 10X GENOMICS, INC. 2020. 47
Slide 47: 10x Genomics Cloud: Launching in 2020
10x Genomics Cloud: Launching in 2020 Cell Ranger, Space Ranger, Loupe in the cloud Zero-stress compute infrastructure Easy-to-use UI, and fast Scalable and elastic Standard analysis included with reagent purchase © 10X GENOMICS, INC. 2020. 48
Slide 48: Best Compute Experience for 10x Software
Best Compute Experience for 10x Software 15-20 hrs ~ $10 < 10 hrs No Cost 1 hr On-Prem DIY 10x Genomics Hardware Cloud Cloud Analysis (expected) © 10X GENOMICS, INC. 2020. 49
Slide 49: Expected launch dates
1H 2020 Mid 2020 2H 2020 1H 2021 ATAC+Gene Exp Targeted Gene Chromium Connect Cell Multiplexing Expression Intracellular Protein Chromium Highly Multiplexed Protein+GEX Immuno- Targeted Gene fluorescence Expression Dedicated FFPE Visium Solution Cell Ranger More Advanced 10x Genomics Cloud 4x Speedu
Slide 50: Towards a Comprehensive View of Biology
Towards a Comprehensive View of Biology Gene Expression Immunology DNA Epigenomics Proteins Chromium Single Cell Visium Spatial © 10X GENOMICS, INC. 2020. 51

10x Genomics — 40th Annual Cowen Health Care Conference (March 2020) on 6ix

10x Genomics — 40th Annual Cowen Health Care Conference (March 2020)

Slide 1: Mastering Biology to Advance Human Health

Slide 2: Safe Harbor Statement

Slide 3: 10x Today

Slide 4: Century of Biology

Slide 5: Biology is Immensely Complex

Slide 6: The Need for High Resolution at Massive Scale

Slide 7: Gene Expression at the Right Resolution and Scale

Slide 8: Major Discoveries Across Life Sciences

Slide 9: Deep Expertise Across Diverse Disciplines

Slide 10: Complete Solutions

Slide 11: Innovation Engine

Slide 12: Product Platforms

Slide 13: Chromium Platform: Millions of Parallel Reactions

Slide 14: Visium Platform: Rich Spatial Characterization

Slide 15: Rapid Growth in Publications Across Life Science

Slide 16: Replacing the Legacy Toolkit Across Biology

Slide 17: Underpenetrated Market: Real-Time PCR Comparison

Slide 18: Creating New Markets Across Life Science Research

Slide 19: Focused and Experienced Commercial Organization

Slide 20: Chromium Use Case: University of Pittsburgh

Slide 21: Global Commercial Footprint

Slide 22: 700 Patents Issued / Filed

Slide 23: Exceptional Financial Profile

Slide 24: Looking Ahead

Slide 25: Chromium Single Cell ATAC + Gene Expression

Slide 26: Unlocking Rules of Epigenetic Programming

Slide 27: Unlocking Rules of Epigenetic Programming

Slide 28: High Concordance Between the Two Read-Outs

Slide 29: Dive Deep Where It Matters

Slide 30: Targeted and Flexible Experiments

Slide 31: Targeted Gene Expression

Slide 32: Targeted Gene Expression, Built the 10x Way

Slide 33: Ready-to-use 10x Genomics Content Offering

Slide 34: From Discovery to Focused Transcriptomics

Slide 35: Cell Multiplexing

Slide 36: Cell Multiplexing, Built The 10x Way

Slide 37: Maximizing Throughput

Slide 38: The Future: 10M cells

Slide 39: Support for New Products in Cell Ranger

Slide 40: Visium: Immunohistochemistry with Gene Expression

Slide 41: Visium: Targeted Gene Expression

Slide 42: Visium: Ultra High Plex Protein Analysis

Slide 43: Protein Protein Protein

Slide 44: Visium: FFPE on Spatial Gene Expression

Slide 45: FFPE Enablement

Slide 46: Visium FFPE on Ovarian Sarcoma Tissue

Slide 47: 10x Genomics Cloud: Launching in 2020

Slide 48: Best Compute Experience for 10x Software

Slide 49: Expected launch dates

Slide 50: Towards a Comprehensive View of Biology

Slide 51: © 10X GENOMICS, INC. 2020.