Evotec Se · XETR:EVT

Evotec — Fact Sheet

2 slides from Evotec's fact sheet

1. Slide 1: Chemical Stability Assessment

   In vitro ADME & PK Chemical Stability Assessment Background Information Protocol Test Article Concentration 5 μM (different concentrations available) • A compound is chemically unstable when it is degraded by non-enzymatic processes. Time Points Degradation may be caused by several 0, 15, 30, 60, 12

2. Slide 2: Degradation of omeprazole over 120 min in simulated gastric fluid

   Oral administration is the route of choice for new drugs. Compounds must be chemically stable at the low pH values observed in the stomach in order for this to be an acceptable route. Figure 1 Degradation of omeprazole over 120 min in simulated gastric fluid. 100 Half-life = 11.2 min 80 % Omeprazole

Evotec — Fact Sheet on 6ix